Tolerance and pancreatic islet transplantation

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 356, Issue 1409, 2001, Pages 759-765

  Inverardi, L ^a   Ricordi, C ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Immunological tolerance; Islet transplantation; Islets of Langerhans; Transplantation; Type I diabetes

Indexed keywords

EID: 0035967489     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.2001.0849     Document Type: Review

References (73)

1. Major histocompatibility complex class I peptide-pulsed host dendritic cells induce antigen-specific acquired thymic tolerance to islet cells
2. Anti-CD4 mediates clonal anergy during transplantation tolerance induction
3. Indefinite islet allograft survival in mice after a short course of treatment with anti-CD45 monoclonal antibodies
4. Antibody-mediated targeting of CD45 isoforms: A novel immunotherapeutic strategy
5. Evidence that intrathymic islet transplantation does not prevent diabetes or subsequent islet graft destruction in RT6-depleted, diabetes-resistant BioBreeding/Worcester rats
6. Improved survival of intraportal pancreatic islet cell allografts in patients with type-1 diabetes mellitus by refined peritransplant management
7. Transplantation of islet cells across major histocompatibility barriers aider total lymphoid irradiation and infusion of allogeneic bone marrow cells
8. Comparative studies of specific acquired systemic tolerance induced by intrathymic inoculation of a single synthetic Wistar-Furth (RT1U) allo-MHC class I (RT1.AU) peptide or WAG (RT1U)-derived class I peptide
9. Long-term functional islet mass and metabolic function after xenoislet transplantation in primates
10. Injection of bone marrow cells into the thymus to achieve tolerance in an islet xenotransplant (human-to-rat) model
11. Cutting edge: Administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning
12. Prevention of xenograft rejection by masking donor HLA class I antigens
13. Induction of tolerance to islet xenografts in a concordant rat-to-mouse model
14. Induction of unresponsiveness to islet xenograft by MMC treatment of graft and blockage of LFA-1/ICAM-1 pathway
15. Xenoislet transplantation: Experimental and clinical aspects
16. Establishment of stable multilineage hematopoietic chimerism and donor-specific tolerance without irradiation
17. Results, research priorities, and reasons for optimism: Islet transplantation for patients with type I diabetes
18. CD4(+) valphal4 natural killer T cells are essential for acceptance of rat islet xenografts in mice
19. Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner
20. Tolerance induction to rat islet allografts by intrathymic inoculation of donor spleen cells
21. Induction of stable chimerism and transplantation tolerance to rat islet and heart allografts by ultraviolet-B modulation of bone marrow cells
22. Anti-CD4 monoclonal antibody-induced allograft tolerance in rats despite persistence of donor-reactive T cells
23. Pancreatic islet xenograft tolerance after short-term costimulation blockade is associated with increased CD4+ T cell apoptosis but not immune deviation
24. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4Ig
25. Mixed xenogeneic chimerism (mouse +rat→ mouse) to induce donor-specific tolerance to sequential or simultaneous islet xenografts
26. Mixed xenogeneic chimerism and tolerance III. A nonlethal approach to induce donor-specific transplantation tolerance to simultaneous islet xenografts
27. Mixed allogeneic chimerism achieved by lethal and nonlethal conditioning approaches induces donor-specific tolerance to simultaneous islet allografts
28. Allogeneic chimerism induces donor-specific tolerance to simultaneous islet allografts in nonobese diabetic mice
29. Blocking the common gamma-chain of cytokine receptors induces T cell apoptosis and long-term islet allograft survival
30. Requirement of CD4 cells for induction and maintenance of unresponsiveness in islet xenografted mice
31. Long-term survival of hamster islet xenografts in mice under short-course treatment with nondepleting versus depleting anti-CD4 monoclonal antibodies
32. Islet transplantation in patients with type I diabetes. Results of 10 years' follow-up
33. NOD mice have a generalized defect in their response to transplantation tolerance induction
34. Intragraft expression of cytokine transcripts during pig proislet xenograft rejection and tolerance in mice
35. T-cell depletion of allogeneic bone marrow using anti-alphabetaTCR monoclonal antibody: Prevention of graft-versus-host disease without affecting engraftment potential in rats
36. Engineered cell lines for insulin replacement in diabetes: Current status and future prospects
37. Anti-LFA-1 therapy induces long-term islet allograft acceptance in the absence of IFN-gamma or IL-4
38. Awareness of donor alloantigens in anti-adhesion therapy induces antigen-specific unresponsiveness to islet allografts
39. Examination of the mechanisms responsible for tolerance induction after intrathymic inoculation of allogeneic bone marrow
40. Transplantation tolerance to rat cardiac and islet allografts by posttransplant intrathymic inoculation of soluble alloantigens
41. Induction of specific unresponsiveness to rat islet allografts by intrathymic UVB donor spleen cells
42. The relative contribution of intrathymic inoculation of donor leukocyte subpopulations in the induction of specific tolerance
43. Effectiveness of intrathymic inoculation of soluble antigens in the induction of specific unresponsiveness to rat islet allografts without transient recipient immunosuppression
44. Induction of peripheral tolerance by intrathymic inoculation of soluble alloantigens: Evidence for the role of host antigen-presenting cells and suppressor cell mechanism
45. Mechanism of acquired thymic tolerance induced by a single major histocompatibility complex class I peptide with the dominant epitope: Differential analysis of regulatory cytokines in the lymphoid and intragraft compartments
46. Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand
47. Studies of privileged sites and organ transplantation
48. Induction of donor-specific unresponsiveness by intrathymic islet transplantation
49. Induction of donor-specific tolerance to rat islet allografts by intrathymic inoculation of solubilized spleen cell membrane antigens
50. Tolerance induction to multiple donor rat islet allografts by intrathymic inoculation of spleen cell membrane antigens
51. Prevention of T-cell activation by rhCTLA4Ig and anti-CD40L monoclonal antibody results in indefinite islet allograft survival
52. The thymic way to transplantation tolerance
53. Islet xenografts in fully xenogeneic (rat → mouse) chimeras: Evidence for normal regulation of function in a xenogeneic mouse environment
54. Indefinite survival of rat islet allografts following infusion of donor bone marrow without cytoablation
55. Autoreactive T cell responses in insulin-dependent (type 1) diabetes mellitus. Report of the first International Workshop for Standardization of T cell assays
56. Long-term survival and strain-specific tolerance induction in rat-to-mouse neonatal islet xenografts
57. Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: Absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice
58. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
59. Evidence that anti-CD8 abrogates anti-CD4-mediated clonal anergy but allows allograft survival in mice
60. Donor cell chimerism permitted by immunosuppressive drugs: A new view of organ transplantation
61. Ex vivo coating of islet cell allografts with murine CTLA4/Fc promotes graft tolerance
62. Reversal of naturally occurring diabetes in primates by unmodified islet xenografts without chronic immunosuppression
63. Peritransplant tolerance induction in macaques: Early events reflecting the unique synergy between immunotoxin and deoxyspergualin
64. Durable donor-specific T and B cell tolerance in rhesus macaques induced with peritrans-plantation anti-CD3 immunotoxin and deoxyspergualin: Absence of chronic allograft nephropathy
65. Distinct mechanisms for the induction and maintenance of allograft tolerance with CTLA4-Fc treatment
66. Intrathymic inoculation of donor antigen: An ineffective strategy for prolonging xenograft survival
67. Mechanisms of tolerance induction after intrathymic islet injection: Determination of the fate of alloreactive thymocytes
68. Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment
69. Insulin-dependent diabetes mellitus and its animal models
70. Long-term survival of donor-specific pancreatic islet xenografts in fully xenogeneic chimeras (WF rat → B10 mouse)
71. Long-term functional xenograft tolerance after intrathymic islet transplantation (Lewis rat → B6 mouse)
72. Inhibition of transplant rejection by pretreatment of xenogeneic pancreatic islet cells with anti-ICAM-1 antibodies
73. CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment