FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons

Journal of Cell Science

Volumn 114, Issue 21, 2001, Pages 3823-3835

  Jenkins, S M ^a   Kizhatil, K ^a   Kramarcy, N R ^a   Sen, A ^a   Sealock, R ^a   Bennett, V ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Adherens junction; Ankyrin; Neurofascin; Neuroglian; Neuromuscular junction; Neuronal migration; Nodes of Ranvier

Indexed keywords

ANKYRIN; CELL ADHESION MOLECULE; NERVE CELL ADHESION MOLECULE; TYROSINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CONTACT; CELL JUNCTION; CELL MIGRATION; CELL POPULATION; CEREBELLUM; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; EMBRYO; EPITHELIUM CELL; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NEUROMUSCULAR SYNAPSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; RAT; SCIATIC NERVE; SIGNAL TRANSDUCTION; VERTEBRATE;

ADHERENS JUNCTIONS; AMINO ACID SEQUENCE; ANIMALS; ANKYRINS; BINDING SITES; CELL ADHESION; CELL ADHESION MOLECULES; CELL ADHESION MOLECULES, NEURONAL; CELL MOVEMENT; CENTRAL NERVOUS SYSTEM; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EPITHELIAL CELLS; LEUKOCYTE L1 ANTIGEN COMPLEX; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; NERVE GROWTH FACTORS; NEURAL CELL ADHESION MOLECULES; NEUROMUSCULAR JUNCTION; NEURONS; PEPTIDES; PHOSPHORYLATION; RATS; TUMOR CELLS, CULTURED; TYROSINE;

ANIMALIA; DROSOPHILA MELANOGASTER; MELANOGASTER; VERTEBRATA;

EID: 0035183588     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (69)

1. The reelin-signaling pathway and mouse cortical development
2. Cadherins and catenins: Role in signal transduction and tumor progression
3. Drosophila neuroglian: A member of the immunoglobulin superfamily with extensive homology to the vertebrate neural adhesion molecule L1
4. The Drosophila PS2 antigen is an invertebrate integrin that, like the fibronectin receptor, becomes localized to muscle attachments
5. Development of electrical properties and synaptic transmission at the embryonic neuromuscular junction
6. LAD-1, the Caenorhabditis elegans L1 CAM homologue, participates in embryonic and gonadal morphogenesis and is a substrate for fibroblast growth factor receptor pathway-dependent phosphotyrosine-based signaling
7. Developmental expression of neural cell adhesion molecules in the mouse neocortex and ofactory bulb
8. Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule L1
9. Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during Drosophila embryogenesis
10. Molecular composition of the node of Ranvier: Identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segments
11. Ankyrin-binding proteins related to nervous system cell adhesion molecules: Candidates to provide transmembrane and intercellular connections in adult brain
12. Abnormalities in neuronal process extension, hippocampal development, and the ventricular system of L1 knockout mice
13. A Drosophila receptor tyrosine phosphatase expressed in the embryonic CNS and Irval optic lobes is a member of the set of proteins bearing the HRP carbohydrate epitope
14. A novel CNS gene required for neuronal migration and involved in X-Linked Subcortical Laminar Heterotopia and Lissencephaly Syndrome
15. Distribution of Na+ channels and ankyrin in neuromuscular junctions is complementary to that of acetylcholine receptors and the 43 kd protein
16. Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons
17. L1-associated diseases: Clinical geneticists divide, molecular geneticists unite
18. The EGF and FGF receptors mediate neuroglian function to control growth cone decisions during sensory axon guidance in Drosophila
19. Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin
20. Doublecortin, a brain-specific gene mutated in human x-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein
21. Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons
22. Mutations in the Drosophila Neuroglian cell adhesion molecule affect motor neuron pathfinding and peripheral nervous system patterning
23. Central nervous system neuronal migration
24. Structural features of a close homologue of L1 (CHL1) in the mouse: A new member of the L1 family of neural recognition molecules
25. In vitro studies of growth cone behavior support a role for fasciculation mediated by cell adhesion molecules in sensory axon guidance during development
26. Structural and functional evolution of the L1 family: Are four adhesion molecules better than one?
27. The L1 family of neural cell adhesion molecules: Old proteins performing new tricks
28. Differential splicing generates a nervous system-specific form of Drosophila neuroglian
29. Impaired neurite outgrowth of src-minus cerebellar neurons on the cell adhesion molecule L1
30. Integrins: A role as cell signalling molecules
31. L1 makes immunological progress by expanding its relations
32. Adhesion molecules and inherited diseases of the human nervous system
33. Neural cell recognition molecule L1: Relating biological complexity to human disease mutations
34. An isoform of ankyrin is localized at nodes of Ranvier in myelinated axons of central and peripheral nerves
35. Ankyrin G: A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of ranvier
36. AnkyrinG is associated with the postsynaptic membrane and the sarcoplasmic reticulum in the skeletal muscle fiber
37. Syntrophin isoforms at the neuromuscular junction: Developmental time course and differential localization
38. Morphogenesis of the node of Ranvier: Co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates
39. The question of the total gene number in Drosophila melanogaster
40. The appearance of an L1-like molecule in the chick primary pathway
41. Expression of the neural axon adhesioin molecule L1 in the developing and adult rat brain
42. L1 mono- and polyclonal antibodies modify cell migration in early postnatal mouse cerebellum
43. Long-distance migration in the adult mammalian brain
44. Chain migration of neuronal precursors
45. Intracellular signals direct integrin localization to sites of function in embryonic muscles
46. Immunolocalization of the neural cell adhesion molecule L1 in epithelial of rodents
47. A sodium channel signaling complex: Modulation by associated receptor protein tyrosine phosphatase beta
48. Membrane glycoproteins involved in neurite fasciculation
49. Embryonic (PSA) N-CAM reveals chains of migrating neuroblasts between the lateral ventricle and the olfactory bulb of adult mice
50. Expression of a dominant negative FGF receptor inhibits axonal growth and FGF receptor phosphorylation stimulated by CAMs
51. Activation of the MAPK signal cascade by the neural cell adhesion molecule L1 requires L1 internalization
52. A MAP kinase-signaling pathway mediates neurite outgrowth on L1 and requires Src-dependent endocytosis
53. Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth
54. Mutations affecting growth cone guidance in Drosophila: Genes necessary for guidance toward or away from the midline
55. Studies of adhesion molecules mediating interactions between cells of peripheral nervous system indicate a major role for L1 in mediating sensory neuron growth on Schwann cells in culture
56. Human doublecortin (DCX) and the homologous gene in mouse encode a putative calcium-dependent signaling protein which is mutated in human X-linked neuronal migration defects
57. Axonin-1, Nr-CAM, and Ng-CAM play different roles in the in vivo guidance of chick commissural neurons
58. An oligodendrocyte cell adhesion molecule at the site of assembly of the paranodal axo-glial junction
59. The development of cellular junctions in the Drosophila embryo
60. Axo-glial septate junctions: The maestro of nodal formation and myelination?
61. The phosphorylation state of the FIGQY tyrosine of neurofascin determines ankyrin-binding activity and patterns of cell segregation
62. Receptor tyrosine kinase specific for the skeletal muscle lineage: Expression in embryonic muscle, at the neuromuscular junction, and after injury
63. Genes that control neuromuscular specificity in Drosophila
64. Neural cell adhesion molecules of the immunoglobulin superfamily: Role in axon growth and guidance
65. Alternative splicing of human NrCAM in neural and nonneural tissues
66. β-Spectrin is colocalized with both voltage-gated sodium channels and ankyrinG at the adult rat neuromuscular junction
67. Structural requirements for association of neurofascin with ankyrin
68. Ankyrin G is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing
69. Tyrosine phosphorylation of L1 family adhesion molecules: Implication of the Eph kinase Cek5