Acute exposure to arsenite induces metallothionein isoform-specific gene expression in human proximal tubule cells

Journal of Toxicology and Environmental Health - Part A

Volumn 64, Issue 4, 2001, Pages 343-355

  Garrett, S H ^a   Belcastro, M ^a   Sens, M A ^a   Somji, S ^a   Sens, D A ^a  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC TRIOXIDE; ARSENITE SODIUM; ISOPROTEIN; MESSENGER RNA; METALLOPROTEIN; METALLOTHIONEIN;

ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEAT; HEAT SHOCK; HUMAN; HUMAN CELL; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; PRIORITY JOURNAL; STRESS;

ARSENITES; CELL CULTURE TECHNIQUES; ENZYME INDUCTION; GENE EXPRESSION REGULATION; HUMANS; ISOENZYMES; KIDNEY TUBULES, PROXIMAL; METALLOTHIONEIN; RNA, MESSENGER; TERATOGENS;

EID: 0035955458     PISSN: 15287394     EISSN: None     Source Type: Journal    
DOI: 10.1080/152873901316981321     Document Type: Article

References (25)

1. Arsenic induces and enhances rat hepatic metallothionein production in vivo
2. Production of metallothionein and heat-shock proteins in response to metals
3. Molecular aspects of arsenic stress
4. Induction of a "stress" protein in intact mammalian organs after intravenous administration of sodium arsenite
5. 2+ induces metallothionein protein accumulation, but not metallothionein isoform 2 mRNA
6. Differential expression of human metallothionein isoform I mRNAs in human proximal tubule cells exposed to metals
7. Expression of MT-3 protein in the human kidney
8. Metallothionein isoform 3 expression in the human prostate and cancer-derived cell lines
9. Metallothionein isoform 1 and 2 gene expression in the human prostate: Down-regulation of MT-1X in advance prostate cancer
10. Sequence of exposure to cadmium and arsenic determines the extent of toxic effects in male Fischer rats
11. Expression of MT-3 mRNA in human kidney, proximal tubule cell cultures, and renal cell carcinoma
12. Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured skin fibroblasts
13. Induction of metallothionein by arsenicals in mice
14. Zinc-induced arsenite tolerance in mice
15. Metallothionein-I/II null mice are more sensitive than wild-type mice to the hepatotoxic and nephrotoxic effects of chronic oral or injected inorganic arsenicals
16. Chemical-form dependent induction of hepatic zinc-thionein by arsenic administration and effect on co-administered selenium in mice
17. Chronic arsenic toxicity in West Bengal - The worst calamity in the world
18. Tissue culture of human renal epithelial cells using a defined serum-free growth formulation
19. Metal carcinogenesis: Mechanistic implications
20. 2
21. 2
22. 2
23. Enzymatic isolation and serum-free culture of human renal cells retaining properties of proximal tubule cells
24. Investigation of chronic arsenic poisoning caused by high arsenic coal pollution