Nucleocytoplasmic shuttling of endocytic proteins

Journal of Cell Biology

Volumn 153, Issue 7, 2001, Pages 1511-1517

  Vecchi, Manuela ^a   Polo, Simona ^a   Poupon, Viviane ^b   Van De Loo, Jan Willem ^a   Benmerah, Alexandre ^b   Di Fiore, Pier Paolo ^a,c,d  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b INSERM   (France)

^c Italian Foundation for Cancer Research   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

CRM1; Endocytosis; eps15; Nucleocytoplasmic shuttling; Transcription

Indexed keywords

ALPHA ADAPTIN; CHROMOSOME PROTEIN; CLATHRIN; EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE 15; EPSIN 1; EXPORTIN 1; MEMBRANE PROTEIN; PROTEIN CALM; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; ENDOCYTOSIS; HUMAN; HUMAN CELL; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL; PROTEIN TRANSPORT; TRANSACTIVATION; TRANSCRIPTION REGULATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ADAPTOR PROTEIN COMPLEX ALPHA SUBUNITS; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; CELL LINE; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; CYTOPLASM; ENDOCYTOSIS; FUNGAL PROTEINS; HELA CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MONOMERIC CLATHRIN ASSEMBLY PROTEINS; NERVE TISSUE PROTEINS; NEUROPEPTIDES; PHOSPHOPROTEINS; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; VESICULAR TRANSPORT PROTEINS;

EID: 0035954425     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.153.7.1511     Document Type: Article

References (29)

1. The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP
2. Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis
3. Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization
4. Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis
5. The cps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport
6. The net repressor is regulated by nuclear export in response to anisomycin, UV, and heat shock
7. eps15, a novel tyrosine kinase substrate, exhibits transforming activity
8. Endocytosis proteins and cancer: A potential link?
9. CRM1 is an export receptor for leucine-rich nuclear export signals
10. CRM1 is responsible for intracellular transport mediated by the nuclear export signal
11. Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2
12. Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZF)
13. The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus
14. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1
15. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region
16. The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5
17. Orchestrated response: A symphony of transcription factors for gene control
18. Nuclear shuttling of yeast scaffold Ste5 is required for its recruitment to the plasma membrane and activation of the mating MAPK cascade
19. The structural era of endocytosis
20. Design of conditionally active STATs: Insights into STAT activation and gene regulatory function
21. Nucleocytoplasmic transport: Signals, mechanisms and regulation
22. Evidence for a role of CRM1 in signal-mediated nuclear protein export
23. LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity
24. GAL4 fusion vectors for expression in yeast or mammalian cells
25. BIN1 is a novel MYC-interacting protein with features of a turnout suppressor
26. The carboxyl terminus of epidermal growth factor receptor/erbB-2 chimerae is internalization impaired
27. Exportin I (Crm1p) is an essential nuclear export factor
28. Transcription factors, normal myeloid development, and leukemia
29. Nuclear export of actin: A novel mechanism regulating the subcellular localization of a major cytoskeletal protein