Hydrophilic, pro-drug analogues of T138067 are efficacious in controlling tumor growth in vivo and show a decreased ability to cross the blood brain barrier

Journal of Medicinal Chemistry

Volumn 44, Issue 22, 2001, Pages 3599-3605

  Rubenstein, S M ^a   Baichwal, V ^a   Beckmann, H ^a   Clark, D L ^a   Frankmoelle, W ^a   Roche, D ^a   Santha, E ^a   Schwender, S ^a   Thoolen, M ^a   Ye, Q ^a   Jaen, J C ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ACETYLAMINO 3 HYDROXY N(2 METHOXY 5 PENTAFLUOROBENZENESULFONYLAMINOPHENYL)PROPIONAMIDE; 2 ACETYLAMINO 3 HYDROXY N(2METHOXY 5 PENTAFLUOROBENZENESULFONYLAMINOPHENYL)BUTYRAMIDE; 2 ACETYLAMINO N (2 METHOXY 5 PENTAFLUOROBENZENESULFONYLAMINOPHENYL)ACETAMIDE; 2 ACETYLAMINO N (2 METHOXY 5 PENTAFLUOROBENZENESULFONYLAMINOPHENYL)PROPIONAMIDE; AMIDE; ANILINE; ANTINEOPLASTIC AGENT; PRODRUG; T 138067; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BREAST TUMOR; CALCULATION; CANCER CELL CULTURE; CANCER GRAFT; CANCER INHIBITION; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; DRUG TRANSPORT; HUMAN; HUMAN CELL; HYDROPHILICITY; IN VIVO STUDY; MALE; MICROTUBULE ASSEMBLY; MOUSE; NONHUMAN;

ANILINE COMPOUNDS; ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD-BRAIN BARRIER; BRAIN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MALE; MICE; MICE, NUDE; POLYMERS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TRANSPLANTATION, HETEROLOGOUS; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0035950186     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000478d     Document Type: Article

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