Addition of peroxisome proliferator-activated receptor α to guinea pig hepatocytes confers increased responsiveness to peroxisome proliferators

Cancer Research

Volumn 59, Issue 19, 1999, Pages 4776-4780

  Macdonald, Neil ^a   Holden, Peter R ^a   Roberts, Ruth A ^a  

^a SK10 4TJ   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A OXIDASE; ALITRETINOIN; LONG CHAIN FATTY ACID; MESSENGER RNA; NAFENOPIN; PALMITOYL COENZYME A; PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; RETINOID X RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FATTY ACID OXIDATION; GUINEA PIG; LIVER CANCER; LIVER CARCINOGENESIS; LIVER CELL; MALE; NONHUMAN; PEROXISOME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REPORTER GENE;

ANIMALS; CELLS, CULTURED; DIMERIZATION; GENE EXPRESSION REGULATION; GENES, REPORTER; GUINEA PIGS; HUMANS; LIVER; LUCIFERASES; MALE; MICE; NAFENOPIN; OXIDATION-REDUCTION; OXIDOREDUCTASES; PEROXISOME PROLIFERATORS; PEROXISOMES; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; RECOMBINANT PROTEINS; RETINOID X RECEPTORS; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TRETINOIN;

EID: 0033214695     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Reddy, J. K., Azamoff, D. L., and Hignite, C. E. Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens. Nature (Lond.), 283: 397-398, 1980.
2. Reddy, J. K., and Lalwani, N. D. Carcinogenesis by hepatic peroxisome proliferators. Evaluation of the risk of hypolidaemic drugs and industrial plasticizers to humans. Crit. Rev. Toxicol., 12: 1-58, 1983.
3. Ashby, J., Brady, A., Elcombe, C. R., Elliot, B. M., Ishmael, J., Odum, J., Tugwood, J. D., Kettle, S., and Purchase, I. F. H. Mechanistically-based human hazard assessment of peroxisome-proliferator-induced hepatocarcinogenesis. Hum. Exp. Toxicol., 13: S1-S117, 1994.
4. Bieri, F., Staubli, W., Waechter, F., Muakkasah-Kelly, S., and Bentley, P. Stimulation of DNA synthesis but not of peroxisomal β-oxidation by nafenopin in primary cultures of marmoset hepatocytes. Cell Biol. Int. Rep., 12: 1077-1087, 1988.
5. Bieri, F., Waechter, F., Sagelsdorff, P., Thomas, H., and Staubli, W. Mechanistic studies on the mitogenic response induced in hepatocytes by nafenopin, a non-mutagenic hepatocarcinogen. Hum. Exp. Toxicol., 10: 86-87, 1991.
6. Bayly, A. C., Roberts, R. A., and Dive, C. Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator, nafenopin. J. Cell Biol., 125: 197-203, 1994.
7. Bentley, P., Calder, I., Elcombe, C. R., Grasso, P., Stringer, D., and Weigand, H-J. Hepatic peroxisome proliferation in rodents and its significance for humans. Food Chem. Toxicol., 31: 857-907, 1993.
8. Aldridge, T. C., Tugwood, J. D., and Green, S. Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription. Biochem. J., 306: 473-479, 1995.
9. Tugwood, J. D., Issemann, I., Anderson, R. G., Bundell, K. R., McPheat, W. L., and Green, S. The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene. EMBO J., 11: 433-439, 1992.
10. Sher, T., Yi, H. F., McBride, W., and Gonzalez, F. J. cDNA cloning, chromosomal mapping and functional characterisation of the human peroxisome proliferator-activated receptor. Biochemistry, 32: 5598-5604, 1993.
11. Williams, G. M., and Perrone. C. Mechanism-based risk assessment of peroxisome proliferating rodent hepatocarcinogens. In: J. K. Reddy, T. Suga, G. P. Mannaerts, P. B. Lazarow, and S. Subramani (eds.), Peroxisomes: Biology and Role in Toxicology and Disease, Vol. 804, pp. 554-572. New York: The New York Academy of Sciences, 1995.
12. Lake, B. G., Evans, J. G., Gray, T. J. B., Korosi, S. A., and North, C. J. Comparative studies on nafenopin-induced hepatic peroxisome proliferation in the rat, Syrian hamster, guinea pig and marmoset. Toxicol. Appl. Pharmacol., 99: 148-160, 1989.
13. Dirvan, H. A., van den Broek, P. H., Peeters, M. C., Peters, J. G., Mennes, W. C., Blaauboer, B. J., Noordhoek, J., and Jongeneelen, F. J. Effects of the peroxisome proliferator mono(2-ethylhexyl)phthalate in primary hepatocyte cultures derived from rat, guinea pig, rabbit, and monkey. Relationship between interspecies differences in biotransformation and peroxisome proliferating potencies. Biochem. Pharmacol., 45: 2425-2434, 1993.
14. Blaauboer, B. J., van Holstein, C. W., Bleumink, R., Mennes, W. C., van Peit, F. N., Yap, S. H., van Pelt, J. F., van Iersel, A. A., Timmerman, A., and Schmidt, B. P. The effects of beclobric acid and clofibric acid on peroxisomal a-oxidation and peroxisome proliferation in primary cultures of rat, monkey and human hepatocytes. Biochem. Pharmacol., 40: 521-528, 1990.
15. Perrone, C. E., Shao, L., and Williams, G. M. Effect of rodent hepatocarcinogenenic peroxisome proliferators on fatty acyl CoA oxidase, DNA synthesis and apoptosis in cultured human and rat hepatocytes. Toxicol. Appl. Pharmacol., 150: 277-286, 1998.
16. Hasmall, S. C., James, N. H., Soames, A., and Roberts, R. A. The peroxisome proliferator nafenopin does not suppress hepatocyte apoptosis in guinea pig liver in vivo nor in human hepatocytes in vitro. Arch. Toxicol., 71: 777-783, 1998.
17. Frick, H., Elo Haapa, K., and Heinonen, O. P. Helsinki heart study: Primary-prevention trial with gemfibrozil in middle-aged men with dislipidemia. N. Engl. J. Med., 317: 1235-1247, 1987.
18. Issemann, I., and Green, S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature (Lond.), 347: 645-650, 1990.
19. Schoonjans, K., Staels, B., and Auwerx, J. Role of the peroxisome proliferator activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J. Lipid Res. 37: 905-925, 1996.
20. Lee, S. S-T., Pineau, T., Drago, J., Lee, E. J., Owens, J. O., Kroetz, D. L., Fernandez-Salguero, P. M., Westphal, H., and Gonzalez, F. J. Targeted disruption of the a isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleitrophic effects of peroxisome proliferators. Mol. Cell. Biol., 15: 3012-3022, 1995.
21. Gonzalez, F. J. Recent update on the PPAR α-null mouse. Biochimie, 79: 139-144, 1997.
22. Peters, J. M., Cattley, R. C., and Gonzalez, F. J. Role of PPAR α in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator, Wy-14,643. Carcinogenesis (Lond.), 18: 2029-2033, 1997.
23. Auwerx, J. Regulation of gene expression by fatty acids and fibric acid derivatives: an integrative role for PPARs. Horm. Res., 38: 269-277, 1992.
24. Forman, B. M., Chen, J., and Evans, R. M. Hypolipidaemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc. Natl. Acad. Sci. USA, 94: 4312-4323, 1997.
25. Kliewer, S. A., Umesono, K., Noonan, D. J., Heyman, R. A., and Evans, R. M. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature (Lond.), 358: 771-774, 1992.
26. Issemann, I., Prince, R. A., Tugwood, J. D., and Green, S. The retinoid X receptor enhances the function of the peroxisome proliferator activated receptor. Biochimie, 75: 251-256, 1993.
27. Zhang, B., Marcus, S. L., Fereydoun, G. S., Alvares, K., Reddy, J. K., Subramani, S., Rachubinski, R. A., and Capone, J. P. Identification of a peroxisome proliferator responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase. Proc. Natl. Acad. Sci. USA, 89: 7541-7545, 1992.
28. Bardot, O., Aldridge, T. C., Latruffe, N., and Green, S. PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene. Biochem. Biophys. Res. Commun., 192: 37-45, 1993.
29. Hertz, R., Bishara-Shieban, J., and Bar-Tana, J. Mode of action of peroxisome proliferators as hypolipidemic drugs. J. Biol. Chem., 270: 13470-13475, 1995.
30. Tugwood, J. D., Aldridge, T. C., Lambe, K. L., Macdonald, N., and Woodyatt, N. J. PPARs: structures and function. In: J. K. Reddy, T. Suga, G. P. Mannaerts, P. B. Lazarow, and S. Subramani (eds.), Peroxisomes: Biology and Role in Toxicology and Disease, Vol. 804, pp. 252-265. New York: New York Academy of Sciences, 1996.
31. Vu-Dac, N., Chopin-Delannoy, S., Gervois, P., Bonnelye, E, Martin, G., Fruchart, J-C., Laudet, V., and Staels, B. The nuclear receptors PPAR-α and Rev-erb-α mediate the species-specific regulation of apolipoprotein AI expression by fibrates. J. Biol. Chem., 273: 25713-25722, 1998.
32. Woodyatt, N., Lambe, K., Myers, K., Tugwood, J., and Roberts, R. The peroxisome proliferator (PP) response element (PPRE) upstream of the human acyl CoA oxidase gene is inactive in a sample human population: significance for species differences in response to PPs, Carcinogenesis (Lond.), 20: 369-375, 1999.
33. Lambe, K., Macdonald, N., Woodyatt, N., Chevalier, S., and Roberts, R. Species differences in sequence and activity of the peroxisome proliferator response element (PPRE) within the acyl CoA oxidase gene promoter. Toxicol. Lett., in press, 1999.
34. Tugwood, J. D., Holden, P. R., James, N. H., Prince, R. A., and Roberts, R. A. A PPAR-α cDNA cloned from guinea pig liver encodes a protein with similar properties to the mouse PPARα: implications for species differences in response to peroxisome proliferators. Arch. Toxicol., 72: 169-177, 1998.
35. Bell, A. R., Savory, R., Horley, N. J., Choudhury, A. I., Dickins, M., Gray, T. J. B., Salter, A. M., and Bell, D. R. Molecular basis of non-responsiveness to peroxisome proliferators: the guinea pig PPAR-α in functional and mediates peroxisome proliferator-induced hypolipidaemia. Biochem. J., 332: 689-693, 1998.
36. Mukherjee, R., Jow, L., Noonan, D., and McDonnell, D. P. Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. J. Steroid Biochem., 51: 157-166, 1994.
37. Kliewer, S. A., Forman, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K., and Evans, R. M. Differential expression and activation of a family of murine peroxisome proliferator activated receptors. Proc. Natl. Acad. Sci. USA, 91: 7355-7359, 1994.
38. Palmer, C. N. A., Hsu, M-H., Griffin, K. J., Raucy, J. L., and Johnson, E. F. Peroxisome proliferator activated receptor a expression in human liver. Mol. Pharmacol., 53: 14-22, 1998.
39. Chevalier, S., and Roberts, R. A. Perturbation of rodent hepatocyte growth control by nongenotoxic hepatocarcinogens: mechanisms and lack of relevance for human health. Oncol. Rep., 5: 1319-1327, 1998.
40. Lambe, K. G., and Tugwood, J. D. A human peroxisome-proliferator-activated receptor-γ is activated by inducers of adipogenesis, including thiazolidinedione drugs. Eur. J. Biochem., 239: 1-7, 1996.
41. James, N. H., and Roberts, R. A. Species differences in response to peroxisome proliferators correlate in vitro with induction of DNA synthesis rather than with suppression of apoptosis. Carcinogenesis (Lond.), 17: 1623-1632, 1996.
42. Roberts, R. A., James, N. H., Woodyatt, N., Macdonald, N., and Tugwood, J. Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor α (PPARα). Carcinogenesis (Lond.), 19: 43-48, 1998.
43. Mitchell, A. M., Bridges, J. W., and Elcombe, C. R. Factors influencing peroxisome proliferation in cultured rat hepatocytes. Arch. Toxicol., 55: 239-246, 1984.
44. Pacot, C., Petit, M., Rollin, M., Behechti, N., Moisant, M., Deslex, P., Althoff, J., Lhuguenot, J. C., and Latruffe, N. Difference between guinea pig and rat in the liver peroxisomal response to equivalent plasmatic level of ciprofibrate. Arch. Biochem. Biophys., 327: 181-188, 1996.
45. Vu-Dac, N., Schoonjans, K., Laine, B., Fruchart, J., Auwerx, J., and Staels, B. Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element. J. Biol. Chem., 269: 31012-31018, 1994.
46. Vu-Dac, N., Schoonjans, K., Kosyth, V., Dallongeville, J., Fruchart, J. C., Staels, B., and Auwerx, J. Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor. J. Clin. Invest., 96: 741-750, 1995.
47. Nishiyama, C., Hi, R., Osada, S., and Osumi, T. Functional interactions between nuclear receptors recognising a common sequence element, the direct repeat motif spaced by one nucleotide (DR-I). J. Biochem., 123: 1174-1179, 1998.