ATP-sensitive K+ channels are involved in the mediation of intrathecal norepinephrine- or morphine-induced antinociception at the spinal level: A study using EMG planimetry of flexor reflex in rats

Brain Research Bulletin

Volumn 45, Issue 3, 1998, Pages 269-273

  Kang, Yu Ming ^a   Zhang, Zhi Hua ^a   Yang, Shou Wei ^a,b   Qiao, Jian Tian ^a   Dafny, Nachum ^b  

^a Shanxi Medical College   (China)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

5' N ethylcarboxamide adenosine; Glibenclamide; Intrathecal; Morphine; Naloxone; Nociceptive flexor reflex; Norepinephrine; Serotonin

Indexed keywords

ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE TRIPHOSPHATE; GLIBENCLAMIDE; MORPHINE; NALOXONE; NORADRENALIN; POTASSIUM CHANNEL; SEROTONIN;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BRAIN STEM; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; FLEXOR REFLEX; HINDLIMB; INTRATHECAL DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD;

ADENOSINE TRIPHOSPHATE; ANALGESICS, OPIOID; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROMYOGRAPHY; GLYBURIDE; INJECTIONS, SPINAL; MALE; MORPHINE; MUSCLE, SKELETAL; NALOXONE; NARCOTIC ANTAGONISTS; NOREPINEPHRINE; POTASSIUM CHANNELS; RATS; RATS, WISTAR; REFLEX, STRETCH;

EID: 0032005420     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(97)00345-6     Document Type: Article

References (25)

1. + channels . Science. 247:1990;852-854.
2. Aran S., Proudfit H. K. Antinociception produced by interactions between intrathecally administered adenosine agonists and norepinephrine. Brain Res. 513:1990;255-263.
3. Aran S., Proudfit H. K. Antinociception interactions between intrathecally administered α noradrenergic agonists and 5′-N-ethylcarboxamide adenosine. Brain Res. 519:1990;287-293.
4. Ashcroft F. M. Adenosine 5′-triphosphate-sensitive potassium channels. Ann. Rev. Neurosci. 11:1988;97-118.
5. Besson J. M., Chaouch A. Peripheral and spinal mechanisms of nociception. Physiol. Rev. 67:1987;167-186.
6. Cook N. S. The pharmacology of potassium channels and their therapeutic potential. Trends Pharmacol. Sci. 9:1988;21-28.
7. 2 adenosine receptors in spinal mechanisms of antinociception. Eur. J. Pharmacol. 139:1987;215-223.
8. Duysens J., Gybels J. The automated measurement of hindlimb flexor reflex of the rat as a substitute for the tail-flick assay. J. Neurosci. Methods. 24:1988;3-79.
9. Evans R. H. The pharmacology of segmental transmission in the spinal cord. Prog. Neurobiol. 33:1989;255-279.
10. Fields H. L., Heinricher M. M., Mason P. Neurotransmitters in nociceptive modulatory circuits. Annu. Rev. Neurosci. 14:1991;219-245.
11. Floeter M. K., Fields H. L. Evidence that inhibition of a nociceptive flexion reflex by stimulation of the rostroventromedial medulla in rats occurs at a premotoneuronal level. Brain Res. 538:1991;340-343.
12. Hökfelt T., Ljungdahl A., Terenius L., Edle R., Nilsson G. Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia enkephalin and substance P . Proc. Nat. Acad. Sci. USA. 74:1977;3081-3085.
13. Narita M., Suzuki T., Misawa M., Nagase H., Nabeshima A., Ashizawa T., Ozawa H., Saito T., Takahata N. Role of central ATP-sensitive potassium channels in the analgesic effect and spinal noradrenaline turnover-enhancing effect of intracerebroventricularly injected morphine in mice. Brain Res. 596:1992;209-214.
14. + channels in cardiac muscle. Nature. 305:1983;147-148.
15. Ocaña M., Pozo E. D., Barrios M., Robles L. I., Baeyens J. M. An ATP-dependent potassium channel blocker antagonizes morphine analgesia. Eur. J. Pharmacol. 186:1990;377-378.
16. Sandkühler J., Gebhart G. F. Characterization of inhibition of a spinal nociception reflex by stimulation medially and laterally in the midbrain and medulla in the pentobarbital-anesthetized rat. Brain Res. 305:1984;67-76.
17. Sawynok J., Sweeney M. I., White T. D. Classification of adenosine receptors mediating antinociception in the rat spinal cord. Br. J. Pharmacol. 88:1986;923-930.
18. 2 adenosine receptors mediating the purine antinociception, motor and autonomic function in the rat spinal cord. J. Pharmacol. Exp. Ther. 250:1989;915-922.
19. Sweeney M. I., White T. D., Sawynok J. Involvement of adenosine in the spinal antinociceptive pathways stimulated by morphine. J. Pharmacol. Exp. Ther. 243:1987;657-665.
20. + release purines from capsaicin-sensistive primary afferent nerve terminals in the spinal cord. J. Pharmacol. Exp. Ther. 248:1989;497-554.
21. Wild K. D., Vanderah T., Mosberg H. I., Porreca F. Opioid δ receptor subtypes are associated with different potassium channels. Eur. J. Pharmacol. 193:1991;135-136.
22. Yaksh T. L., Rudy T. Chronic catheterization of the subarachnoid space. Physiol. Behav. 17:1976;1031-1036.
23. Yaksh T. L., Wilson P. R. Spinal serotonin terminal system mediates antinociception. J. Pharmacol. Exp. Ther. 208:1979;446-453.
24. Yang S. W., Zhang Z. H., Chen J. Y., Xie Y. F., Qiao J. T., Dafny N. Morphine and norepinephrine-induced antinociception at the spinal level is mediated by adenosine. Neuroreport. 5:1994;1441-1444.
25. Zhang Z. H., Yang S. W., Xie Y. F., Qiao J. T. Effects of naloxone and aminophylline on the antinociception induced by serotonin and norepinephrine at the spinal level A study using EMG planimetry of flexor reflex in rats . Chin. J. Physiol. Sci. 10:1994;139-145.