Synthesis of conformationally restricted analogs of baclofen, a potent GABA(B) receptor agonist, by the introduction of a cyclopropane ring

Chemical and Pharmaceutical Bulletin

Volumn 47, Issue 8, 1999, Pages 1188-1192

  Shuto, Satoshi ^a   Shibuya, Nobuko ^a   Yamada, Shizuo ^b   Ohkura, Takashi ^b   Kimura, Ryohei ^b   Matsuda, Akira ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Baclofen; Conformationally restricted analog; Cyclopropane; aminobutyric acid

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; BACLOFEN; UNCLASSIFIED DRUG; [2 CARBOXY 1 (4 CHLOROPHENYL)CYCLOPROPYLMETHYL]AMMONIUM CHLORIDE;

ANIMAL TISSUE; ARTICLE; CONFORMATIONAL TRANSITION; DRUG CONFORMATION; DRUG FORMULATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0032851532     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.47.1188     Document Type: Article

References (3)

1. a) Bowery N. G., Hudson A. L., Piece G. W., Neuroscience, 20, 365-383 (1987);
2. b) Nicxoll R. A., Science, 241, 545-551 (1988).
3. Hill D. R., Bowery N. G., Nature (London), 290, 149-152 (1981).