Hexosamine regulation of glucose-mediated laminin synthesis in mesangial cells involves protein kinases A and C

American Journal of Physiology - Renal Physiology

Volumn 279, Issue 4 48-4, 2000, Pages

  Singh, Lalit P ^a   Crook, Errol D ^a,b  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^b G V SONNY MONTGOMERY VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Diabetic nephropathy; Hexosamine biosynthesis pathway; Laminin

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUCOSE; HEXOSAMINE; LAMININ; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; DIABETIC NEPHROPATHY; ENZYME ACTIVITY; GLUCOSE METABOLISM; KIDNEY METABOLISM; MESANGIUM CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT;

EID: 0033679319     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.2000.279.4.f646     Document Type: Article

References (45)

1. Diabetes induces changes in glomerular development and laminin-β2 (s-laminin) expression
2. High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures
3. Transforming growth factor-β in diabetic nephropathy
4. High glucose and TGF-β down regulate glutamine:fructose-6-P amidotransferase in mesangial cells
5. Regulation of insulin-stimulated glycogen synthase activity by overexpression of glutamine:fructose-6-phosphate amidotransferase in rat-1 fibroblasts
6. Regulation of glycogen synthase by glucose, glucosamine, and glutamine:fructose-6-phosphate amidotransferase
7. Glucose regulation of transforming growth factor alpha expression is mediated by products of the hexosamine biosynthesis pathway
8. Transcriptional regulation of TGF-β1 by glucose: Investigation into the role of the hexosamine biosynthesis pathway
9. Effect of high glucose on type IV collagen production by cultured glomerular, endothelial and mesangial cells
10. The effects of intensive insulin treatment of diabetes on the development and progression of long term complications in insulin-dependent diabetes mellitus
11. Glomerular and kidney extracellular matrix gene expression in experimental diabetes
12. High glucose concentrations and protein kinase C isoforms in vascular smooth muscle cells
13. Reduced O glycosylation of Sp1 is associated with increased proteosome susceptibility
14. Glycosylation in the nucleus and cytoplasm
15. Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance
16. Glucosamine-induced insulin resistance in 3T3-L1 adipocytes is caused by depletion of intracellular ATP
17. Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells
18. Autocrine secretion of transforming growth factor-β in cultured rat mesangial cells
19. Translocation of protein kinase Cα and ζ in rat glomerular mesangial ceils cultured under high glucose conditions
20. High glucose-induced transforming growth factor β1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells
21. Monoclonal antibodies specific for type 3 protein kinase C recognize distinct domains of protein kinase C and inhibit in vitro functional activity
22. Adenosine 3',5'-cyclic monophosphate mimics the inhibitory effect of high glucose on MAP kinase phosphorylation in rat mesangial cells
23. The kidney in diabetes
24. Hexosamines and insulin resistance
25. Glucose and glucosamine regulate growth factor gene expression in vascular smooth muscle cells
26. Effects of high glucose on cellular proliferation and fibronectin production by cultured human mesangial cells
27. Role of transforming growth factor β in thromboxane induced increases in mesangial cell fibronectin synthesis
28. Regulation of protein kinase C
29. Diabetic glomerulopathy: Structural characteristics of the early and advanced stages
30. Regulation of the laminin C1 promoter in cultured mesangial cells
31. Mechanisms of glucose-enhanced extracellular matrix accumulation in rat glomerular mesangial cells
32. Renal hypertrophy in hyperglycemic nonobese diabetic mice is associated with persistent renal accumulation of insulin-like growth factor-1
33. Neutralization of TGF-β by anti-TGF-β antibody attenuates kidney hypertrophy and the enhanced extracellular matrix protein expression in STZ-induced diabetic mice
34. Hyperglycemia and diabetic kidney disease: The case of transforming growth factor-β as a key mediator
35. Low density lipoprotein stimulation of mesangial cell fibronectin synthesis: Role of protein kinase C and transforming growth factor β
36. Protein kinase C signals thromboxane induced increases in fibronectin synthesis and TGF-β bioactivity in mesangial cells
37. Transforming growth factor-β 1 stimulates protein kinase A in mesangial cells
38. Characterization of glucoseinduced in situ protein kinase C activity in cultured vascular smooth muscle cells
39. Glucose-induced protein kinase C activity regulates arachidonic acid release and eicosanoid production by cultured glomerular mesangial cells
40. Angiotensin II stimulates the proliferation and biosynthesis of type i collagen in cultured murine mesangial cells
41. High glucose-induced proliferation of mesangial cells is reversed by autocrine TGF-β
42. Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels
43. Overexpression of transforming growth factor-β 1 mRNA is associated with up-regulation of glomerular tenascin and laminin gene expression in nonobese diabetic mice
44. Role of protein kinase C and cyclic AMP/protein kinase A in high glucose-stimulated transcriptional activation of collagen α1 (IV) in glomerular mesangial cells
45. Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-β