Novel strategy for the synthesis of fluorinated β-amino acid derivatives from Δ2-oxazolines

Tetrahedron

Volumn 57, Issue 30, 2001, Pages 6475-6486

  Fustero, Santos ^a   Salavert, Esther ^a   Pina, Belén ^a   Ramírez De Arellano, Carmen ^a   Asensio, Amparo ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Amino acids and derivatives; Fluorine and compounds; Imidoyl halides; Oxazolines

Indexed keywords

1 (4,4 DIMETHYL 4,5 DIHYDRO 1,3 OXAZOL 2 YLMETHYL) 2,2,2 TRIFLUOROETHYL(4 METHOXYPHENYL)AMINE; 1 (4,4 DIMETHYL 4,5 DIHYDRO 1,3 OXAZOL 2 YLMETHYL) 2,2,3,3,3 PENTAFLUOROPROPYL(4 METHOXYPHENYL)AMINE; 1 (4,5 DIHYDRO 1,3 OXAZOL 2 YLMETHYL) 2,2,2 TRIFLUOROETHYL(4 METHOXYPHENYL)AMINE; 1 (4,8B DIHYDRO 3AH INDENO[2,1 D][1,3]OXAZOL 2 YLMETHYL) 2,2,2 TRIFLUOROMETHYL(4 METHOXYPHENYL)AMINE; 1 [1 (4,5 DIHYDRO 1,3 OXAZOL 2 YL)ETHYL] 2,2 3,3,3 PENTAFLUOROPROPYL(4 METHOXYPHENYL)AMINE; 1 [4 TERT BUTYL 4,5 DIHYDRO 1,3 OXAZOL 2 YLMETHYL] 2,2,2 TRIFLUOROETHYL(4 METHOXYPHENYL)AMINE; 1 CHLORO(DIFLUORO)METHYL 2 (4,5 DIHYDRO 1,3 OXAZOL 2 YL) 1 ETHENYL(4 METHOXYPHENYL)AMINE; 2 (4 TERT BUTYL 4,5 DIHYDRO 1,3 OXAZOL 2 YL) 1 TRIFLUOROMETHYL 1 ETHENYL(4 METHOXYPHENYL)AMINE; 2 (4,4 DIMETHYL 4,5 DIHYDRO 1,3 OXAZOL 2 YL) 1 (1,1,2,2,2 PENTAFLUOROETHYL) 1 ETHENYL(4 METHOXYPHENYL)AMINE; 2 (4,5 DIHYDRO 1,3 OXAZOL 2 YL) 1 TRIFLUOROMETHYL 1 ETHENYL(4 METHOXYPHENYL)AMINE; 2 (4,8B DIHYDRO 3AH INDENO[2,1 D][1,3]OXAZOL 2 YL) 1 TRIFLUOROMETHYL 1 ETHENYL(4 METHOXYPHENYL)AMINE; 2 CHLORO 1 (4,5 DIHYDRO 1,3 OXAZOL 2 YLMETHYL) 2,2 DIFLUOROETHYL(1 PHENYLETHYL)AMINE; 2 CHLORO 1 (4,5 DIHYDRO 1,3 OXAZOL 2 YLMETHYL) 2,2 DIFLUOROETHYL(4 METHOXYPHENYL)AMINE; 2 CHLORO 2,2 DIFLUORO 1 (4 METHOXYMETHYL 5 PHENYL 4,5 DIHYDRO 1,3 OXAZOL 2 YLMETHYL)ETHYL(4 METHOXYPHENYL)AMINE; 2 CHLORO 2,2 DIFLUORO 1 (4 PHENYL 4,5 DIHYDRO 1,3 OXAZOL 2 YLMETHYL)ETHYL(4 METHOXYPHENYL)AMINE; 3 CHLORO(DIFLUORO)METHYL 2 (4 PHENYL 4,5 DIHYDRO 1,3 OXAZOL 2 YL) 1 ETHENYL(4 METHOXYPHENYL)AMINE; 4 METHOXYPHENYL[2 (4 PHENYL 4,5 DIHYDRO 1,3 OXAZOL 2 YL) 1 TRIFLUOROMETHYL 1 ETHENYL]AMINE; 4 METHOXYPHENYL[2,2,2 TRIFLUORO 1 (4 ISOPROPYL 4,5 DIHYDRO 1,3 OXAZOL 2 YLMETHYL)ETHYL]AMINE; 4 METHOXYPHENYL[2,2,2 TRIFLUORO 1 (4 METHOXYMETHYL 5 PHENYL 4,5 DIHYDRO 1,3 OXAZOL 2 YLMETHYL)ETHYL]AMINE; 4 METHOXYPHENYL[2,2,2 TRIFLUORO 1 (4 PHENYL 4,5 DIHYDRO 1,3 OXAZOL 2 YLMETHYL)ETHYL]AMINE; [1 [CHLORO(DIFLUORO)METHYL] 2 (4,5 DIHYDRO 1,3 OXAZOL 2 YL) 1 ETHENYL](1 PHENYLETHYL)AMINE; BETA AMINO ACID; BETA AMINO DELTA 2 OXAZOLINE DERIVATIVE; BETA ENAMINO DELTA 2 OXAZOLINE DERIVATIVE; CYCLOHEXYL [1 (4,5 DIHYDRO 1,3 OXAZOL 2 YLMETHYL) 2,2,2 TRIFLUOROETHYL]AMINE; CYCLOHEXYL[2 (4,5 DIHYDRO 1,3 OXAZOL 2 YL) 1 TRIFLUOROMETHYL 1 ETHENYL]AMINE; UNCLASSIFIED DRUG;

ARTICLE; DIASTEREOISOMER; DRUG STRUCTURE; DRUG SYNTHESIS; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOCHEMISTRY; STOICHIOMETRY;

EID: 0035939185     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(01)00539-7     Document Type: Article

References (64)

1. Organo-Fluorine Compounds