Studies on human porin XXI: Gadolinium opens up cell membrane standing porin channels making way for the osmolytes chloride or taurine - A putative approach to activate the alternate chloride channel in cystic fibrosis

Molecular Genetics and Metabolism

Volumn 69, Issue 3, 2000, Pages 240-251

  Thinnes, Friedrich P ^a   Hellmann, Klaus P ^a   Hellmann, Thea ^a   Merker, Rolf ^a   Schwarzer, Christian ^a   Walter, Götz ^b   Götz, Hilde ^a   Hilschmann, Norbert ^a  

^a MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^b UNIVERSITY HOSPITAL MARBURG   (Germany)

Author keywords

Anion channels; Chloride channels; Osmoregulation; Outwardly rectifying chloride channel (ORCC); Porin; RVD; Voltage dependent anion selective channel; Volume regulation; Volume sensitive organic osmolyte anion channel (VSDAC)

Indexed keywords

ANION CHANNEL; CHLORIDE; CHLORIDE CHANNEL; GADOLINIUM; PORIN; TAURINE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STIMULATION; CYSTIC FIBROSIS; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; ION TRANSPORT; LIGHT SCATTERING; LIPID BILAYER; OSMOREGULATION; OSMOTIC STRESS; PRIORITY JOURNAL;

VERTEBRATA;

EID: 0034053980     PISSN: 10967192     EISSN: None     Source Type: Journal    
DOI: 10.1006/mgme.2000.2968     Document Type: Article

References (78)

1. Guggino W B. Outwardly rectifying chloride channels and CF: A divorce and remarriage. J Bioenerg Biomembr. 25:1993;27-35.
2. Kunzelmann K, Schreiber R. CFTR, a regulator of channels. J Membr Biol. 168:1999;1-8.
3. Frizzell R A. Physiology of cystic fibrosis. Physiol Rev. 79:1999;S1-S255.
4. Janisch U, Skofitsch G, Thinnes F P, Graier W F, Groschner K. Evidence for the involvement of a plasma membrane porin in agonist-induced activation of vascular endothelial cells. Naunyn-Schmiedeberg's Arch Pharmacol. 347:1993;R73.
5. Dermietzel R, Hwang T-K, Buettner R, Hofer A, Dotzler E, Kremer M, Deutzmann R, Thinnes F P, Fishman G I, Spray D C, Siemen D. Cloning and in situ localization of a brain-derived porin that constitutes a large-conductance anion channel in astrocytic plasma membranes. Proc Natl Acad Sci USA. 91:1994;499-503.
6. Puchelle E, Jacquot J, Fuchey C, Burlet H, Klossek J-M, Gilain L, Triglia J-M, Thinnes F P, Hilschmann N. Studies on human porin IX. Immunolocalization of Porin and CFTR channels in human surface respiratory epithelium. Biol Chem Hoppe-Seyler. 374:1993;297-304.
7. Hein, A, Kiafard, Z, Hesse, D, Hesse, J-O, Zimmermann, B, Kratzin, H, D, Schulz, H, Reiss, J, Thinnes, F, P, Götz, H, Hilschmann, N, Swiss-Prot, Accession P21796, Dezember 1997.
8. Heiden M, Kroll K, Thinnes F P, Hilschmann N. Proteins of cytosol and amniotic fluid increase the voltage dependence of human type-1 porin. J Bioenerg Biomembr. 28:1996;171-180.
9. Flörke H, Thinnes F P, Winkelbach H, Stadtmüller U, Paetzold G, Morys-Wortmann C, Hesse D, Sternbach H, Zimmermann B, Kaufmann-Kolle P, Heiden M, Karabinos A, Reymann S, Lalk V E, Hilschmann N. Channel active mammalian porin, purified from crude membrane fractions of human B lymphocytes and bovine skeletal muscle, reversibly binds adenosine triphosphate (ATP): Studies on human porin, part XI. Biol Chem Hoppe-Seyler. 375:1994;513-520.
10. Thinnes F P, Flörke H, Winkelbach H, Stadtmüller U, Heiden M, Karabinos A, Hesse D, Kratzin H D, Fleer E, Hilschmann N. Channel active mammalian porin, purified from crude membrane fractions of human B lymphocytes or bovine skeletal muscle, reversibly binds the stilbene-disulfonate group of the chloride channel blocker DIDS: Studies on human porin, part X. Biol Chem Hoppe-Seyler. 375:1994;315-322.
11. Rohm, B, Schmid, A, Maier, E, Thinnes, F, P, Hilschmann, N, Taurine passing human porin makes the channel a candidate for the volume-sensitive organic osmolyte-anion channel (VSOAC). The 1996 Albany Conference Frontiers of Mitochondrial Research, Rensselaerville Conference Center, USA, Sept. 19-22, Abstract 39.
12. Reymann S, Flörke H, Heiden M, Jakob C, Stadtmüller U, Steinacker P, Lalk V E, Pardowitz I, Thinnes F P. Further evidence for multi-topological localization of mammalian porin (VDAC) in the plasmalemma forming part of a chloride channel complex affected in cystic fibrosis and encephalomyopathy. Biochem Mol Med. 54:1995;75-87.
13. Thinnes F P, Reymann S. New findings concerning vertebrate porin. Naturwissenschaften. 84:1997;480-498.
14. - channels in normal and cystic fibrosis epithelial cells. Am J Physiol. 261:1991;C658-C674.
15. Lepple-Wienhues A, Szabo I, Laun T, Kaba N K, Gulbins E, Lang F. The tyrosine kinase P56(LCK) mediates activation of swelling-induced chloride channels in lymphocytes. J Cell Biol. 141:1998;281-286.
16. Guggino W. Chloride channels. Curr Top Membr. 42:1994;1-354.
17. Steinacker P, Reymann S, Schwarzer C, Walter G, Kratzin H, Thinnes F P, Hilschmann N. Endogenous expression of VDAC in the plasma membrane of Xenopus laevis oocytes. Pflügers Arch Eur J Physiol. 433:1997;R141.
18. Steinacker P, Sternbach H, Rohm B, Walter G, Thinnes F P, Hilschmann N. VDAC is involved in osmotically activated taurine-efflux in HeLa cells. Pflügers Arch Eur J Physiol. 433:1997;R162.
19. Steinacker P. Studien zur Funktionsbestimmung von plasmamembranal exprimiertem VDAC. 1998.
20. Steinacker P, Awni L A, Becker S, Cole T, Reymann S, Hesse D, Kratzin H D, Morris-Wortmann C, Schwarzer C, Thinnes F P, Hilschmann N. The plasma membrane of Xenopus laevis oocytes contains voltage-dependent anion-selective porin channels. Int J Biochem Cell Biol. 32:2000;225-234.
21. Horn A, Reymann S, Thinnes F P. Studies on human porin XVI: Polyamines reduce the voltage dependence of human VDAC in planar lipid bilayers - spermine and spermidine inducing asymmetric voltage gating on the channel. Mol Genet Metab. 63:1998;239-242.
22. Siadat S, Reymann S, Horn A, Thinnes F P. Studies on human porin XVIII: the multi-compartment effector ruthenium red reduces the voltage-dependence of human VDAC in planar lipid bilayers. Mol Genet Metab. 65:1998;246-249.
23. Hellmann K P, Siadat S, Reymann S, Thinnes F P. Studies on human porin XIX: Zinc ions reduce the voltage-dependence of human type-1 porin integrated in artificial planar lipid bilayers barium ions do not. Mol Genet Metab. 67:1999;176-180.
24. Poulin R, Pegg A E. Regulation of ornithine decarboxylase expression by anisosmotic shock in α-difluoromethyl-ornithine-resistant L1210 Cells. J Biol Chem. 265:1990;4025-4032.
25. Watts S A, Yeh E W, Henry R P. Hypoosmotic stimulation of ornithine decarboxylase activity in the brine shrimp Artemia franciscana. J Exp Zool. 274:1996;15-22.
26. Mitchell J LA, Judd G G, Leyser A, Choe Ch-y. Osmotic stress induces variation in cellular levels of ornithine decarboxylase-antizyme. Biochem J. 329:1998;453-459.
27. Thinnes, F, P, Hilschmann, N, Gadolinium discussed as an ORCC opener. The First International Conference on the Secretion Defect in Cystic Fibrosis, Athos Palace Hotel, Chalkidiki, Greece, May 5-8, Abstract 16.
28. Thinnes, F, P, Walter, G, Hellmann, K, P, Hellmann, T, Merker, R, Kiafard, Z, Eben-Brunnen, J, Schwarzer, C, Götz, H, Hilschmann, N, Gadolinium discussed as an opener of the outwardly rectifying chloride channel (ORCC): Is there relevance for cystic fibrosis therapy, ? Proceedings of the First International Conference on the Secretion Defect in Cystic Fibrosis, Athos Palace Hotel, Chalkidiki, Greece, May 5-8, submitted.
29. Thinnes F P, Götz H, Kayser H, Benz R, Schmidt W E, Kratzin H D, Hilschmann N. Zur Kenntnis der Porine des Menschen I. Reinigung eines Porins aus menschlichen B-Lymphozyten (Porin 31HL) und sein topochemischer Nachweis auf dem Plasmalemm der Herkunftszelle. Biol Chem Hoppe-Seyler. 370:1989;1253-1264.
30. Benz R, Maier E, Thinnes F P, Götz H, Hilschmann N. Studies on human porin VII: The channel properties of the human B-lymphocyte membrane-derived "Porin 31HL" are similar to those of mitochondrial porins. Biol Chem Hoppe-Seyler. 373:1992;295-303.
31. Caldwell R A, Clemo H F, Baumgarten C M. Using gadolinium to identify stretch-activated channels: Technical considerations. Am J Physiol. 275:1998;C619-C621.
32. Fuhrmann G F, Liggenstorfer P, Wilbrandt W. Änderung des Glucosetransports frischer menschlicher Erythrocytzen bei längerer Inkubation. Experientia. 27:1971;1428-1430.
33. König U, Götz H, Walter G, Babel D, Hohmeier H-E, Thinnes F P, Hilschmann N. Zur Kenntnis der Porine des Menschen V. Die Plasmalemmständigkeit von "Porin 31HL" ist keine Folge einer Zell-Transformation. Biol Chem Hoppe-Seyler. 372:1991;565-572.
34. Cole T, Awni L A, Nyakatura E, Götz H, Walter G, Thinnes F P, Hilschmann N. Studies on human porin VIII: Expression of "Porin 31HL" channels in the plasmalemma of the acute-lymphoblastic-leukemia cell line KM3 as revealed by light- and electron-microscopy. Biol Chem Hoppe-Seyler. 373:1992;891-896.
35. Jakob C, Götz H, Hellmann T, Hellmann K P, Reymann S, Flörke H, Thinnes F P, Hilschmann N. Studies on human porin XIII: The type-1 VDAC "Porin 31HL" biotinylated at the plasmalemma of trypan blue excluding human B lymphocytes. FEBS Lett. 368:1995;5-9.
36. Eben-Brunnen J, Reymann S, Awni L A, Cole T, Hellmann T, Hellmann K P, Paetzold G, Kleinecke J, Thinnes F P, Götz H, Hilschmann N. Lentil lectin enriched microsomes from the plasma membrane of the human B-lymphocyte cell line H2LCL carry a heavy load of type-1 porin. Biol Chem. 379:1998;1419-1426.
37. Thinnes F P, Schmid A, Benz R, Hilschmann N. Studies on human porin III: Does the voltage-dependent anion channel "Porin 31HL" form part of the chloride channel complex, which is observed in different cells and thought to be affected in cystic fibrosis. Biol Chem Hoppe-Seyler. 371:1990;1047-1050.
38. Thinnes F P, Babel D, Hein A, Jürgens L, König U, Schmid A, Hilschmann N. Ein Flip-Flop-Modell des Chlorid-Kanal-Komplexes erklärt die Fehlregulation des Chloridflusses am Plasmalemm von Zellen bei der cystischen Fibrose. Klin Wochenschr. 69:1991;283-288.
39. Lippmann B J, Yang R, Barnett D W, Misler S. Pharmacology of volume regulation following hypotonicity-induced cell swelling in clonal N1E115 neuroblastoma cells. Brain Res. 686:1995;29-36.
40. + release in A6 epithelia. Am J Physiol. 275:1998;C189-C199.
41. Wilkinson N C, Gao F, Hamill O P. Effects of mechano-gated cation channel blockers on Xenopus oocyte growth and development. J Membr Biol. 165:1998;161-174.
42. Lee J, Ishihara A, Oxford G, Johnson B, Jacobson K. Regulation of cell movement is mediated by stretch-activated calcium channels. Nature. 400:1999;382-386.
43. Urbach V, Leguen I, O'Kelly I, Harvey B J. Mechanosensitive calcium entry and mobilization in renal A6 cells. J Membr Biol. 168:1999;29-37.
44. Stadtmüller U, Schmid A, Benz R, Thinnes F P, Hilschmann N. Mitochondrial and extra-mitochondrial human porin are identical. Biophys J. 72:1997;A348.
45. Stadtmüller U, Eben-Brunnen J, Schmid A, Hesse D, Klebert S, Kratzin H D, Hesse J, Zimmermann B, Reymann S, Thinnes F P, Benz R, Götz H, Hilschmann N. Mitochondria-derived and extra-mitochondrial human type-1 porin are identical as revealed by amino acid sequencing and electrophysiological characterisation. Biol Chem. 380:1999;1461-1466.
46. Kayser H, Kratzin H D, Thinnes F P, Götz H, Schmidt W E, Eckart K, Hilschmann N. Zur Kenntnis der Porine des Menschen. II. Charakterisierung und Primärstruktur eines 31-kDa-Porins aus menschlichen B-Lymphozyten (Porin 31HL). Biol Chem Hoppe-Seyler. 370:1989;1265-1278.
47. Strange K, Jackson P S. Swelling-activated organic osmolyte efflux: A new role for anion channels. Kidney Int. 48:1995;994-1003.
48. Kirk K. Swelling-activated organic osmolyte channels. J Membr Biol. 158:1997;1-16.
49. - channel: Fresh start to the molecular identity and volume sensor. Am J Physiol. 273:1997;C755-C789.
50. Lang F, Busch G L, Ritter M, Volkl H, Waldegger S, Gulbins E, Haussinger D. Functional significance of cell volume regulatory mechanisms. Physiol Rev. 78:1998;247-306.
51. Nilius B, Prenen J, Droogmans G. Modulation of volume-regulated anion channels by extra- and intracellular pH. Pflügers Arch-Eur J Physiol. 436:1998;742-748.
52. Perlmann D F, Goldstein L. Organic osmolyte channels in cell volume regulation in vertebrates. J Exp Zool. 283:1999;725-733.
53. Grunewald R W, Kinne R KH. Osmoregulation in the mammalian kidney: The role of organic osmolytes. J Exp Zool. 283:1999;708-724.
54. Valverde M A. ClC channels: Leaving the dark ages on the verge of a new millennium. Curr Opin Cell Biol. 11:1999;509-516.
55. Stutzin A, Torres R, Oporto M, Pacheco P, Eguiguren A L, Cid L P, Sepúlveda F V. Separate taurine and chloride efflux pathways activated during regulatory volume decrease. Am J Physiol. 277:1999;C392-C402.
56. Trouet D, Nilius B, Jacobs A, Remacle C, Droogmans G, Eggermont J. Caveolin-1 modulates the activity of the volume-regulated chloride channel. J Physiol. 520.1:1999;113-119.
57. Blatz A L, Magleby K L. Single voltage-dependent chloride-selective channels of large conductance in cultured rat muscle. Biophys J. 43:1983;237-241.
58. Jalonen T, Johansson S, Holopainen I, Oja S S, Arhem P. A high-conductance multi-state anion channel in cultured rat astrocytes. Acta Physiol Scand. 136:1989;611-612.
59. Kimelberg H K, Anderson E, Kettenmann H. Swelling-induced changes in electrophysiological properties of cultured astrocytes and oligodendrocytes. II. Whole cell currents. Brain Res. 529:1990;262-268.
60. 2+-dependent Cl-channels in undifferentiated human colonic cells (HT-29). II. Regulation and rundown. Am J Physiol. 264:1993;C977-C985.
61. Babel D, Walter G, Götz H, Thinnes F P, Jürgens L, König U, Hilschmann N. Studies on human porin VI: Production and characterization of eight monoclonal mouse antibodies against the human VDAC "Porin 31HL" and their application for histotopological studies in human skeletal muscle. Biol Chem Hoppe-Seyler. 372:1991;1027-1034.
62. Winkelbach H, Walter G, Morys-Wortmann C, Paetzold G, Hesse D, Zimmermann B, Flörke H, Reymann S, Stadtmüller U, Thinnes F P, Hilschmann N. Studies on human porin XII: Eight monoclonal mouse anti-"Porin 31HL" antibodies discriminate type 1 and type 2 mammalian porin channels/VDACs in western blotting and enzyme-linked immunosorbent assays. Biochem Med Metab Biol. 52:1994;120-127.
63. Reymann S, Kiafard Z, Rohm B, Strutz N, Hesse D, Kratzin H D, Zimmermann B, Thinnes F P, Hilschmann N. Purification procedure and monoclonal antibodies: Two instruments for research on vertebrate porins. Anal Biochem. 274:1999;289-295.
64. Báthori G, Parolini I, Tombola F, Szabo I, Messina A, Oliva M, De Pinto V, Lisanti M, Sargiacomo M, Zoratti M. Porin is present in the plasma membrane where it is concentrated in caveolae and caveolae-related domains. J Biol Chem. 274:1999;29607-29612.
65. Jürgens L, Ilsemann P, Kratzin H D, Hesse D, Eckart K, Thinnes F P, Hilschmann N. Studies on human porin IV: The primary structure of "Porin 31HM" purified from human skeletal muscle membranes and of "Porin 31HL" derived from human B lymphocyte membranes are identical. Biol Chem Hoppe-Seyler. 372:1991;455-463.
66. Jürgens L, Kleineke J, Brdiczka D, Thinnes F P, Hilschmann N. Localization of type-1 porin channel (VDAC) in the sarcoplasmatic reticulum. Biol Chem Hoppe-Seyler. 376:1995;685-689.
67. Junankar P R, Curtis S M, Pace S M, Dulhunty A F. Immunogold localisation of the VDAC channel in mammalian skeletal and cardiac muscle. Proc Austral Physiol Pharmacol Soc. 24:1993;179P.
68. Junankar P R, Dulhunty A F, Curtis S M, Pace S M, Thinnes F P. Porin-type1 proteins in sarcoplasmic reticulum and plasmalemma of striated muscle fibres. J Muscle Res Cell Motil. 16:1995;595-610.
69. Shoshan-Barmatz V, Hadad N, Feng W, Shafir I, Orr I, Varsanyi M, Heilmeyer L MG. VDAC/porin is present in sarcoplasmic reticulum from skeletal muscle. FEBS Lett. 386:1996;205-210.
70. Quinton P M. Cystic fibrosis: A disease in electrolyte transport. FASEB J. 4:1990;2709-2717.
71. Welsh M J. Abnormal regulation of ion channels in cystic fibrosis epithelia. FASEB J. 4:1990;2718-2725.
72. Chen, J, H, Schulman, H, Gardner, P. A cAMP-regulated chloride channel in lymphocytes that is affected in cystic fibrosis. Science243:657-660.
73. Wang K, Li R, Cheng Y, Zhu B. Lanthanides - The future drugs. Coordination Chem Rev. 190-192:1999;297-308.
74. Hamill O P, McBride D W Jr. The pharmacology of mechanogated membrane ion channels. Pharmacol Rev. 48:1996;231-252.
75. +-alanine cotransport activates a voltage-dependent conductance in single proximal tubule cells isolated from frog kidney. J Physiol. 517.1:1999;193-200.
76. + currents. Br J Pharmacol. 127:1999;1819-1831.
77. Zambrowicz E B, Colombini M. Zero-current potentials in a large membrane channel: a simple theory accounts for complex behavior. Biophys J. 65:1993;1093-1100.
78. Levitan I, Garber S S. Anion competition for a volume-regulated current. Biophys J. 75:1998;226-235.