The association of Nef with a cellular serine/threonine kinase and its enhancement of infectivity are viral isolate dependent

Journal of Virology

Volumn 70, Issue 9, 1996, Pages 6493-6496

  Luo, Tianci ^a   Garcia, J Victor ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; NEF PROTEIN; PROTEIN SERINE THREONINE KINASE;

ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; VIRUS GENE; VIRUS INFECTIVITY;

EID: 0029835631     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.9.6493-6496.1996     Document Type: Article

References (33)

1. Aiken, C., J. Konner, N. R. Landau, M. E. Lenburg, and D. Trono. 1994. Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 76:853-864.
2. Aldrovandi, G. M., and J. A. Zack. 1996. Replication and pathogenicity of human immunodeficiency virus type 1 accessory gene mutants in SCID-hu mice. J. Virol. 70:1505-1511.
3. Allan, J. S., J. E. Coligan, T. H. Lee, M. F. McLane, P. J. Kanki, J. E. Groopman, and M. Essex. 1985. A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients. Science 230:810-813.
4. Anderson, S. J., M. Lenburg, N. R. Landau, and J. V. Garcia. 1994. The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef. J. Virol. 68:3092-3101.
5. Anderson, S. J., D. C. Shugars, R. Swanstrom, and J. V. Garcia. 1993. Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells. J. Virol. 67:4923-4931.
6. Beaver, B., and F. Wong-Staal. 1989. Structure of simian immunodeficiency virus regulatory gene. Proc. Natl. Acad. Sci. USA 86:4813-4817.
7. Benson, R. E., A. Sanfridson, J. S. Oltinger, C. Doyle, and B. R. Cullen. 1993. Downregulation of cell surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection. J. Exp. Med. 177:1561-1566.
8. Dalgleish, A. G., P. C. L. Beverly, P. R. Clapham, D. H. Crawford, M. F. Greaves, and R. A. Weiss. 1984. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature (London) 312: 763-767.
9. Deacon, N. J., A. Tsykin, A. Solomon, K. Smith, M. Ludford-Menting, D. J. Hooker, D. A. McPhee, A. L. Greenway, A. Ellett, C. Chatfield, V. A. Lawson, S. Crowe, A. Maerz, S. Sonza, J. Learmont, J. S. Sullivan, A. Cunningham, D. Dwyer, D. Dowton, and J. Mills. 1995. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science 270:988-991.
10. open. Virology 201:373-379.
11. Garcia, J. V., and A. D. Miller. 1991. Serine phosphorylation-independent downregulation of cell-surface CD4 by Nef. Nature (London) 350:508-511.
12. Goldsmith, M. A., M. T. Warmerdam, R. E. Atchison, M. D. Miller, and W. C. Green. 1995. Dissociation of the CD4 downregulation and virus infectivity enhancement functions of human immunodeficiency virus type 1 Nef. J. Virol. 69:4112-4121.
13. Guy, B., M. P. Kieny, Y. Riviere, C. L. Peuch, K. Dott, M. Girard, L. Montagnier, and J. P. Lecocq. 1987. HIV F/3′ orf encodes a phosphorylated GTP-binding protein resembling an oncogene product. Nature (London) 330:266-269.
14. Jamieson, B. D., G. M. Aldrovandi, V. Planelles, J. B. M. Jowett, L. Gao, L. M. Bloch, I. S. Y. Chen, and J. A. Zack. 1994. Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity. J. Virol. 68:3478-3485.
15. Kannagi, M., J. M. Yetz, and N. L. Letvin. 1985. In vitro growth characteristics of simian T-lymphotropic virus type III. Proc. Natl. Acad. Sci. USA 82:7053-7057.
16. Kestler, H. W., III, D. J. Ringler, K. Mori, D. L. Panicali, P. K. Sehgal, M. D. Daniel, and R. C. Desrosiers. 1991. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65:651-662.
17. Kim, S., R. Byrn, J. Groopman, and D. Baltimore. 1989. Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: evidence for differential gene expression. J. Virol. 63:3708-3713.
18. Kimpton, J., and M. Emerman. 1992. Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated β-galactosidase gene. J. Virol. 66: 2232-2239.
19. Klatzman, D., E. Champagne, S. Chamaret, J. Gruest, D. Guetard, T. Hercend, J. C. Gluckman, and L. Montagnier. 1984. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature (London) 312: 767-768.
20. Klotman, M. E., S. Kim, A. Buchbinder, A. Derossi, D. Baltimore, and F. Wong-Staal. 1991. Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes. Proc. Natl. Acad. Sci. USA 88:5011-5015.
21. Landau, N. R., M. Warton, and D. R. Littman. 1988. The envelope glycoprotein of human immunodeficiency virus binds to the immunoglobulin-like domain of CD4. Nature (London) 334:159-162.
22. Luo, T., S. J. Anderson, and J. V. Garcia. 1996. Inhibition of Nef- and phorbol ester-induced CD4 degradation by macrolide antibiotics. J. Virol. 70:1527-1534.
23. Maddon, P. J., A. G. Dalgleish, J. S. Mcdougal, P. R. Clapham, R. A. Weiss, and R. Axel. 1986. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47:333-348.
24. Mariani, R., and J. Skowronski, 1993. CD4 downregulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals. Proc. Natl. Acad. Sci. USA 90:5549-5553.
25. Miller, M. D., M. T. Warmerdam, I. Gaston, W. C. Green, and M. B. Feinberg. 1994. The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages. J. Exp. Med. 179:101-113.
26. Munis, J. R., R. S. Kornbluth, J. C. Guatelli, and D. D. Richman. 1992. Ordered appearance of human immunodeficiency vrus type 1 nucleic acids following high multiplicity infection of macrophages. J. Gen. Virol. 73:1899-1906.
27. Obaru, K., J. E. deClue, and W. A. Haseltine. 1992. An amino-terminal amino acid affects the electrophoretic mobility of the HIV-1 Nef protein. J. Acquired Immune Defic. Syndr. 5:308-312.
28. Robert-Guroff, M., M. Popovic, S. Gartner, P. Markham, R. C. Gallo, and M. S. Reitz. 1990. Structure and expression of tat-, rev-, and nef-specific transcripts of human immunodeficiency virus type 1 in infected lymphocytes and macrophages. J. Virol. 64:3391-3398.
29. Sawai, E. T., A. S. Baur, B. M. Peterlin, J. A. Levy, and C. Cheng-Mayer. 1995. A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity. J. Biol. Chem. 270:15307-15314.
30. Sawai, E. T., A. S. Baur, H. Strubel, B. M. Peterlin, J. A. Levy, and C. Cheng-Mayer. 1994. Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes. Proc. Natl. Acad. Sci. USA 91:1539-1543.
31. Sawai, E. T., I. H. Khan, C. Cheng-Mayer, and P. A. Luciw. 1996. Association of Nef with a cellular protein kinase is important for pathogenesis in SIV-infected rhesus macaques, p. 48. Abstracts of Keystone Symposia. In B. M. Peterlin and B. Cullen (ed.), Molecular biology of HIV. Keystone Symposia on Molecular and Cellular Biology, Silverthorne, Colo.
32. AGM. J. Virol. 64:742-747.
33. Spina, C. A., T. J. Kwoh, M. Y. Chowers, J. C. Guatelli, and D. D. Richman. 1994. The importance of Nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes. J. Exp. Med. 179:115-123.