Kinetics of rate-dependent shortening of action potential duration in guinea-pig ventricle; effects of I(K1) and I(Kr) blockade

British Journal of Pharmacology

Volumn 126, Issue 6, 1999, Pages 1426-1436

  Williams, Beatrice A ^a,c   Dickenson, David R ^a,d   Beatch, Gregory N ^a,b,d  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Action potential duration; Class III anti arrhythmic agent; Dofetilide; Inward rectifier potassium current; Rate dependence; Restitution; Terikalant

Indexed keywords

DOFETILIDE; TERIKALANT;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; GUINEA PIG; HEART MUSCLE POTENTIAL; HEART PACING; HEART VENTRICLE WALL; ISOLATED HEART; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL;

EID: 0033042843     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702443     Document Type: Article

References (36)

1. BASS, B.G. (1975). Restitution of the action potential in cat papillary muscle. Am. J. Physiol., 228, 1717-1724.
2. BASSINGTHWAIGHTE, J.B., FRY, C.H. & MCGUIGAN, J.A.S. (1976). Relationship between internal calcium and outward current in mammalian ventricular muscle; a mechanism for the control of the action potential duration? J. Physiol. (Lond.), 262, 15-37.
3. BIERMANS, G., VEREECKE, J. & CARMELIET, E. (1987). The mechanism of the inactivation of the inward-rectifying K current during hyperpolarization steps in guinea-pig ventricular myocytes. Pflügers Arch., 410, 13.
4. BOYETT, M.R. & FEDIDA, D. (1984). Changes in the electrical activity of dog cardiac Purkinje fibres at high heart rates. J. Physiol. (Lond.), 350, 361-391.
5. BOYETT, M.R. & JEWELL, B.R. (1978). A study of the factors responsible for rate-dependent shortening of the action potential in mammalian ventricular muscle. J. Physiol. (Lond.), 285, 359-380.
6. BOYETT, M.R. & JEWELL, B.R. (1980). Analysis of the effects of changes in rate and rhythm upon electrical activity in the heart. Prog. Biophys. Mol. Bio., 36, 1-52.
7. BRIDAL, T.R., REES, S.A., SPINELLI, W. & COLATSKY, T.J. (1996). Terikalant (RP62719) is not a selective blocker ofinward rectifier current in cat ventricular myocytes. Circulation, 94, 1- 529(Abstract).
8. CARMELIET, E. (1992). Voltage- and time block of the delayed K+ current in cardiac myocytes by dofetilide. J. Pharmacol. Exp. Ther., 262, 809-817.
9. CARMELIET, E. (1993). K+ channels and control of ventricular repolarization in the heart. Fundam. Clin. Pharmacol., 7, 19-28.
10. COLATSKY, T.J. & HOGAN, P.M. (1980). Effects of external calcium, calcium channel-blocking agents, and stimulation frequency on cycle length-dependent changes in canine cardiac action potential duration. Circ. Res., 46, 543-552.
11. DELMAR, M., IBARRA, J., DAVIDENKO, J., LORENTE, P. & JALIFE, J. (1991). Dynamics of the background outward current of single guinea pig ventricular myocytes. Circ. Res., 69, 1316-1326.
12. DICKENSON, D.R., DAVIS, D.R. & BEATCH, G.N. (1997). Development and evaluation of a fully automated monophasic action potential analysis program. Med. Biol. Eng. Comp., 35, 653 -660.
13. + current in frog cardiomyocytes by β-adrenergic agonists and Mg2+. J. Physiol (Lond.), 415, 251-274.
14. ELHARRAR, V. & SURAWICZ, B. (1983). Cycle length effect on restitution of action potential duration in dog cardiac fibers. Am. J. Physiol., 244, H782-H792.
15. + current acting as pure class III antiarrhythmic agents. J. Cardiovasc. Pharmacol., 20 (Suppl. 2), S106-S113.
16. GETTES, L.S. & REUTER, H. (1974). Slow recovery from inactivation of inward currents in mammalian myocardial fibres. J. Physiol. (Lond.), 240, 703-724.
17. GWILT, M., ARROWSMITH, J.E., BLACKBURN, K.J., BURGES, R.A., CROSS, P.E., DALRYMPLE, H.W. & HIGGINS, A.J. (1991). UK-68,798: A novel, potent and highly selective class III antiarhythmic agent which blocks potassium channels in cardiac cells. J. Pharmacol. Exp. Ther., 256, 318-324.
18. HAUSWIRTH, O. NOBLE, D. & TSIEN, R.W. (1972). The dependence of plateau currents in cardiac Purkinje fibres on the interval between action potentials. J. Physiol. (Lond.) 222, 27-49.
19. HONDEGHEM, L.M. & SNYDERS, D.J. (1990). Class III antiarhythmic agents have a lot of potential but a long way to go: Reduced effectiveness and dangers of reverse use dependence. Circulation, 81, 686-690.
20. + current by dofetilide. Circ. 72,75-83.
21. JURKIEWICZ, N.K., WANG, J., FERMINI, B., SANGUINETTI, M.C. & SALATA, J.J. (1996). Mechanism of action potential prolongation by RP58866 and its active enantiomer terikalant. Circulation, 94, 2938-2946.
22. KAMEYAMA, M., KAMEYAMA, A., NAKAYAMA, T. & KAIBARA M.(1988). Tissue extract recovers cardiac calcium channels from 'run-down'. Pflügers Arch., 412, 328-330.
23. KLINE, R.P. & MORAD, M. (1978). Potassium efflux in heart muscle during activity: Extracellular accumulation and its implications. J. Physiol. (Lond.), 280, 537-558 .
24. KURACHI Y. (1985). Voltage-dependent activation of the inward rectifier potassium channel in the ventricular cell membrane of guinea-pig heart. J. Physiol (Lond.), 366, 365-385.
25. MAZZANTI, M. & DEFRANCESCO, D. (1989). Intracellular Ca modulates K-inward rectification in cardiac myocytes. Pflügers Arch., 413, 322-324.
26. MCLARNON, J.G. & XU, R. (1995). Actions of the benzopyran compound terikalant on macroscopic currents in rat ventricular myocytes. J. Pharmacol. Exp. Ther., 275, 389-396.
27. OPTHOF, T. (1994). IKI blockade is unlikely to be a useful antiarrhythmic mechanism. Cardiovasc. Res., 28, 420.
28. POWELL, T., TERRAR, D.A. & TWIST, V.W. (1980). Electrical properties of individual cells isolated from adult rat ventricular myocardium. J. Physiol. (Lond.), 302, 131-153.
29. KI blockade: A new antiarrhythmic mechanism? Effect of RP58866 on ventricular arrhythmias in rat, rabbit, and primate. Circulation, 87, 1979-1989.
30. KI blockade is a potentially useful antiarrhythmic mechanism. Cardiovasc Res., 28, 421.
31. ROBINSON, R.B., BOYDEN, P.A., HOFFMAN, B.A. & HEWETT K.W. (1987). Electrical restitution process in dispersed canine cardiac Purkinje and ventricular cells. Am. J. Physiol., 253, H1018-H1025 .
32. SAITOH, H., BAILEY, J.C. & SURAWICZ, B. (1988). Alternans of action potential duration after abrupt shortening of cycle length: Differences between dog Purkinje and ventricular muscle fibers. Circ. Res., 62, 1027-1040.
33. SHIMONI Y., CLARK, R.B. & GILES, W.R. (1992). Role of an inwardly rectifying potassium current in rabbit ventricular action potential J. Physiol. (Lond.). 448, 709-727.
34. SURAWLCZ B. (1992). Role of potassium channels in cycle length dependent regulation of action potential duration in mammaliancardiac Purkinje and ventricular muscle fibers. Cardiovasc. Res.,26, 1021-1029.
35. VAUGHAN WILLIAMS, E.M. (1970). Classification of antiarrhythmic drugs. In: Symposium on Cardiac Arrhythmias, ed. Sandoe, E., Flensted-Jensen, E., Olesen, K.H. pp. 449-472.
36. WILLIAMS, B.A. & BEATCH, G.N. (1997). Magnesium shifts voltage dependence of activation of delayed rectifier IK in guinea-pig ventricular myocytes. Am. J. Physiol., 272 (Heart Circ. Physiol. 41): H1292-H1301.