BCL-2 protein expression correlates with nodal status in non small cell lung cancer

Anticancer Research

Volumn 19, Issue 1 B, 1999, Pages 821-824

  Groeger, Angela M ^a   Caputi, Mario ^b   Esposito, Vincenzo ^b,c   De Luca, Antonio ^c   Salat, Andreas ^a   Murabito, Marco ^a   Giordano, Giovan Giacomo ^b   Baldi, Feliciano ^b   Giordano, Antonio ^c   Wolner, Ernst ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

bcl 2; Immunohistochemistry; Lung cancer

Indexed keywords

PROTEIN BCL 2; TUMOR MARKER;

ADENOCARCINOMA; ADULT; ARTICLE; CANCER STAGING; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA;

ADENOCARCINOMA; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR MARKERS, BIOLOGICAL;

EID: 0032922476     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Bellamy CO, Malcomson RD, Harrison DJ, Wyllie AH: Cell death in health and disease: the biology and regulation of apoptosis. Cancer Biol 6: 3-16, 1995.
2. Reed JC: Bcl-2 and the regulation of programmed cell death. J Cell Biol 124: 1-6, 1994.
3. Yang E, Korsmeyer SJ: Molecular thanatopsis: a discourse on the Bcl-2 family and cell death. Blood 88: 386-401, 1996.
4. Tsujimoto Y, Croce CM: Analysis of the structure, transcripts, and protein products of bcl, the gene involved in human follicular lymphoma. Proc Natl Acad Sci 83: 5214-5218, 1986.
5. Oltivai ZN, Milliman CL, Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell 74: 609-619, 1993.
6. Boise LH, Gonzalez-Garcia M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nunez G, Thompson CB: Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74: 597-608, 1993.
7. McDonnell TJ, Korsmeyer SJ: Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18). Nature 394: 254-256, 1991.
8. World Health Organization: Histological typing of lung tumors. 2nd ed., Geneva pp. 25-26, 1981.
9. Beahrs OH, Henson DE, Hutter RVP, Kennedy BJ: Lung. In: Manual for staging of cancer. 4th ed. Chicago, American Joint Committee on Cancer pp.115-122, 1992.
10. Akao Y, Otsuki Y, Kataoka S, Ito Y, Tsujimoto Y: Multiple subcellular localization of bcl-2: detection in nuclear outer membrane, endoplasmic reticulum membrane and mitochondrial membranes. Cancer Res 54: 2468-2471, 1994.
11. Korsmeyer SJ: Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 80: 879-886, 1992.
12. Lithgow T, Vandriel R, Bertram JF, Strasser A: The protein product of oncogene Bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum and the outer mitochondrial membrane. Cell Growth Different 4: 411-417, 1994.
13. Higashiyama M, Doi O, Kodama K, Yokouchi H, Tateishi R: High prevalence of bcl-2 oncoprotein expression in small cell lung cancer. Anticancer Res 15: 503-505, 1995.
14. Pezzella F, Turley H, Kuzu I, Tangekar MF, Dunnill MS, Pierce CB, Harris A, Gatter KC, Mason DY: Bcl-2 protein in non-small cell lung carcinoma. N Engl J Med 329: 690-694, 1993.
15. Shottenfeld D: Epidemiology of lung cancer. In Lung Cancer: Principles and Practice, ed. by Pass HI, Mitchell JB, Johnson, Turrisi AT, Lippincot-Raven Publishers, Philadelphia, 1996.