Quorum signaling via Al-2 communicates the "metabolic burden" associated with heterologous protein production in Escherichia coli

Biotechnology and Bioengineering

Volumn 75, Issue 4, 2001, Pages 439-450

  Delisa, Matthew P ^a,b   Valdes, James J ^c   Bentley, William E ^a,b  

^a UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c US Army Edgewood Research   (United States)

Author keywords

Al 2; Cell to cell communication; Global gene regulation; LuxS; Recombinant protein expression

Indexed keywords

ESCHERICHIA COLI; GENES; PROTEINS;

CELL DENSITY;

BIOTECHNOLOGY;

AUTOINDUCER 2; PROTEIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM CULTURE; CELL COMMUNICATION; CELL DENSITY; ESCHERICHIA COLI; FERMENTATION; GENE INDUCTION; GENE OVEREXPRESSION; GROWTH RATE; NONHUMAN; PLASMID; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

BACTERIAL PROTEINS; BIOREACTORS; CELL COMMUNICATION; CELL COUNT; CULTURE MEDIA, CONDITIONED; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; GENES, REPORTER; HOMOSERINE; HYDROGEN-ION CONCENTRATION; INTERLEUKIN-2; LACTONES; LUMINESCENCE; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SOLUBILITY; TEMPERATURE; TIME FACTORS; VIBRIO;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0035923319     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10034     Document Type: Article

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