A regulatory hydrophobic area in the flexible joint region of plasminogen activator inhibitor-1, defined with fluorescent activity-neutralizing ligands. Ligand-induced serpin polymerization

Journal of Biological Chemistry

Volumn 276, Issue 16, 2001, Pages 13077-13086

  Egelund, Rikke ^a   Einholm, Anja P ^a   Pedersent, Katrine E ^a   Nielsen, Rasmus W ^a   Christensen, Anni ^a   Deinumi, Johanna ^b   Andreasen, Peter A ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACIDS; ENZYMES; FLUORESCENCE; HYDROPHOBICITY; POLYMERIZATION;

PLASMINOGEN ACTIVATORS;

BIOCHEMISTRY;

4,4' DIANILINO 1,1' BINAPHTHYL 5,5' DISULFONIC ACID; 8 ANILINO 1 NAPHTHALENESULFONIC ACID; LIGAND; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEINASE; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; UROKINASE; VITRONECTIN; 1-ANILINO-8-NAPHTHALENESULFONATE; 5,5' BIS(8 (PHENYLAMINO) 1 NAPHTHALENESULFONATE); 5,5'-BIS(8-(PHENYLAMINO)-1-NAPHTHALENESULFONATE); FLUORESCENT DYE; PEPTIDE FRAGMENT;

ALPHA HELIX; ARTICLE; BINDING SITE; CANCER; CARDIOVASCULAR DISEASE; COMPLEX FORMATION; FLUORESCENCE; HYDROPHOBICITY; LIGAND BINDING; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN TARGETING; SPECTROSCOPY; AMINO ACID SEQUENCE; BINDING COMPETITION; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; KINETICS; MACROMOLECULE; METABOLISM; PROTEIN SECONDARY STRUCTURE; SPECTROFLUOROMETRY;

AMINO ACID SEQUENCE; ANILINO NAPHTHALENESULFONATES; BINDING, COMPETITIVE; FLUORESCENT DYES; HUMANS; KINETICS; LIGANDS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN STRUCTURE, SECONDARY; SERPINS; SPECTROMETRY, FLUORESCENCE; URINARY PLASMINOGEN ACTIVATOR;

EID: 0035918137     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009024200     Document Type: Article

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