Identification of the binding site for a low-molecular-weight inhibitor of plasminogen activator inhibitor type 1 by site-directed mutagenesis

Biochemistry

Volumn 37, Issue 5, 1998, Pages 1227-1234

  Björquist, Petter ^a   Ehnebom, Johanna ^a   Inghardt, Tord ^a   Hansson, Lennart ^b   Lindberg, Maria ^b   Linschoten, Marcel ^a   Strömqvist, Mats ^b   Deinum, Johanna ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b Molecular Biology   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

FLUFENAMIC ACID; PLASMINOGEN ACTIVATOR INHIBITOR 1;

ARTICLE; BINDING SITE; DRUG EFFECT; DRUG RECEPTOR BINDING; FIBRINOLYSIS; HUMAN; MOLECULAR WEIGHT; PRIORITY JOURNAL; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

ANIMALS; ANTIBODIES, MONOCLONAL; BINDING SITES; BINDING SITES, ANTIBODY; BIOSENSING TECHNIQUES; CHEMISTRY, ANALYTICAL; CHLORPHENAMIDINE; CHO CELLS; CHROMOGENIC COMPOUNDS; CRICETINAE; FLUFENAMIC ACID; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR WEIGHT; MUTAGENESIS, SITE-DIRECTED; NITRO COMPOUNDS; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLASMINOGEN INACTIVATORS; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; TISSUE PLASMINOGEN ACTIVATOR;

EID: 0039518548     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi971554q     Document Type: Article

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