The discovery of anthranilic acid-based MMP inhibitors. Part 3: Incorporation of basic amines

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 22, 2001, Pages 2975-2978

  Levin, J I ^a   Chen, J M ^a   Du, M T ^a   Nelson, F C ^a   Wehr, T ^a   DiJoseph, J F ^a   Killar, L M ^a   Skala, S ^a   Sung, A ^a   Sharr, M A ^a   Roth, C E ^a   Jin, G ^a   Cowling, R ^a   Di, L ^a   Sherman, M ^a   Xu, Z B ^a   March, C J ^b   Mohler, K M ^b   Black, R A ^b   Skotnicki, J S ^a  

^a PFIZER INC   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; ANTHRANILIC ACID DERIVATIVE; ANTINEOPLASTIC AGENT; ANTIRHEUMATIC AGENT; CGS 27023A; COLLAGENASE 3; GELATINASE B; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE INHIBITOR; METALLOPROTEINASE INHIBITOR; PIPERAZINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATTLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; RAT;

ADAM PROTEINS; AMINES; ANIMALS; ANTHRANILIC ACIDS; BINDING SITES; COLLAGENASES; ENZYME INHIBITORS; HYDROXAMIC ACIDS; INTERLEUKIN-1; INTERLEUKIN-1BETA; MAGNETIC RESONANCE SPECTROSCOPY; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 9; METALLOENDOPEPTIDASES; MICE; MODELS, MOLECULAR; OSTEOARTHRITIS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035914612     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00601-1     Document Type: Article

References (20)