The discovery of anthranilic aci-based MMP inhibitors. Part 1: SAR of the 3-position

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 2, 2001, Pages 235-238

  Levin, Jeremy I ^a   Du, Mila T ^a   DiJoseph, John F ^a   Killar, Loran M ^a   Sung, Amy ^a   Walter, Thomas ^a   Sharr, Michele A ^a   Roth, Catherine E ^a   Moy, Franklin J ^a   Powers, Robert ^a   Jin, Guixian ^a   Cowling, Rebecca ^a   Skotnicki, Jerauld S ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRANILIC ACID DERIVATIVE; CGS 27023A; COLLAGENASE 3; GELATINASE B; HYDROXAMIC ACID DERIVATIVE; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE INHIBITOR; ANTHRANILIC ACID; COLLAGENASE; HYDROXAMIC ACID; MATRIX METALLOPROTEINASE; MMP13 PROTEIN, HUMAN; MMP13 PROTEIN, RAT; PROTEINASE INHIBITOR; SULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARTILAGE; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMISTRY; COMBINATORIAL CHEMISTRY; DRUG ANTAGONISM; HUMAN; IC 50; SYNTHESIS;

ANIMALS; ANTHRANILIC ACIDS; COLLAGENASES; COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS; HYDROXAMIC ACIDS; INHIBITORY CONCENTRATION 50; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0035931128     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00642-9     Document Type: Article

References (30)