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Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 22, 2001, Pages 2893-2896

A unique ring-expanded acyclic nucleoside analogue that inhibits both adenosine deaminase (ADA) and guanine deaminase (GDA; guanase): Synthesis and enzyme inhibition studies of 4,6-diamino-8H-1-hydroxyethoxymethyl-8-iminoimidazo[4,5-e][1,3]diazepine

(2) Wang, Lijuan a Hosmane, Ramachandra S a

a UNIVERSITY OF MARYLAND BALTIMORE COUNTY (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,6 DIAMINO 8H 1 HYDROXYETHOXYMETHYL 8 IMINOIMIDAZO[4,5 E][1,3]DIAZEPINE; ACYCLIC NUCLEOSIDE; ADENOSINE DEAMINASE; ANTIVIRUS AGENT; GUANINE DEAMINASE; NUCLEOSIDE ANALOG; PURINE; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; PURINE METABOLISM;

ADENOSINE DEAMINASE; ANIMALS; AZEPINES; ENZYME INHIBITORS; GUANINE DEAMINASE; IMIDAZOLES; LIVER; RABBITS;

EID: 0035914591 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/S0960-894X(01)00591-1 Document Type: Article

Times cited : (23)

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