Novel cell type-specific antiviral mechanism of interferon γ action in macrophages

Journal of Experimental Medicine

Volumn 193, Issue 4, 2001, Pages 483-496

  Presti, Rachel M ^a   Popkin, Daniel L ^a   Connick, Megan ^a   Paetzold, Susanne ^a   Virgin IV, Herbert W ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytomegalovirus; Interferon ; Macrophage; Microarray analysis; Signal transducer and activator of transcription 1

Indexed keywords

GAMMA INTERFERON; IMMEDIATE EARLY PROTEIN; STAT1 PROTEIN;

ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DNA MICROARRAY; DRUG MECHANISM; EMBRYO; MACROPHAGE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UNINDEXED SEQUENCE; VIRUS PATHOGENESIS; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; BONE MARROW CELLS; CYTOMEGALOVIRUS; EIF-2 KINASE; ENDORIBONUCLEASES; FIBROBLASTS; GENE EXPRESSION PROFILING; INTERFERON TYPE II; INTERFERON-ALPHA; INTERFERON-STIMULATED GENE FACTOR 3; MACROPHAGES; MICE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RNA, MESSENGER; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035910758     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.193.4.483     Document Type: Article

References (100)

1. Reduced mortality in murine cytomegalovirus infected mice following prophylactic murine interferon-gamma treatment
2. Studies of relationship between mouse cytomegalovirus and interferon
3. Role of interferon-gamma in murine cytomegalovirus infection
4. Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands
5. Restoration of cytomegalovirus antigen presentation by gamma interferon combats viral escape
6. Requirement for natural killer cell-produced interferongamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration
7. Interferon-gamma regulates acute and latent murine cytomegalovirus infection and chronic disease of the great vessels
8. The role of LY49 NK cell subsets in the regulation of murine cytomegalovirus infections
9. The T cell independent role of IFN-gamma and TNF-alpha in macrophage activation during murine cytomegalovirus and herpes simplex virus infection
10. Hierarchical and redundant lymphocyte subset control precludes cytomegalovirus replication during latent infection
11. Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumor necrosis factor
12. Cure of fibroblast monolayers from murine cytomegalovirus infection: Phenotypic assessment of rat lymphoid cell population developed on fibroblast monolayers
13. Interferons inhibit onset of murine cytomegalovirus immediate-early gene transcription
14. Cytomegalovirus replication in murine microglial cell cultures: Suppression of permissive infection by interferon-gamma
15. + T-cell clones specifically activated by IE1 peptides in vitro
16. Mechanisms of viral inhibition by interferons
17. Antiviral actions of interferon, interferon-regulated cellular proteins and their surprisingly selective antiviral activities
18. The interferon system: A bird's eye view of its biochemistry
19. Propagation of salivary gland virus of the mouse in tissue culture
20. Peripheral blood mononuclear phagocytes mediate dissemination of murine cytomegalovirus
21. Detection of murine cytomegalovirus DNA in circulating leukocytes harvested during acute infection of mice
22. Disseminated cytomegalovirus infection. Molecular analysis of virus and leukocyte interactions in viremia
23. Biphasic viremia and viral gene expression in leukocytes during acute cytomegalovirus infection of mice
24. Murine cytomegalovirus infection suppresses interferon-gamma-mediated MHC class II expression on macrophages: The role of type I interferon
25. Murine cytomegalovirus with a deletion spanning HindIII-J and -I displays altered cell and tissue tropism
26. Replication of murine cytomegalovirus in differentiated macrophages as a determinant of viral pathogenesis
27. Latent murine cytomegalovirus infection in macrophages
28. Pathogenesis of murine cytomegalovirus infection: The macrophage as a permissive cell for cytomegalovirus infection, replication, and latency
29. Murine cytomegalovirus DNA in peripheral blood of latently infected mice is detectable only in monocytes and polymorphonuclear leukocytes
30. The 89,000-Mr murine cytomegalovirus immediate-early protein activates gene transcription
31. Characterization of the murine cytomegalovirus early transcription unit e1 that is induced by immediate-early proteins
32. Defective growth correlates with reduced accumulation of a viral DNA replication protein after low-multiplicity infection by a human cytomegalovirus ie1 mutant
33. Modulation of murine macrophage behavior in vivo and in vitro
34. Murine cytomegalovirus inhibits interferon-gamma induced antigen presentation to CD4 T cells by macrophages via regulation of MHC class II associated genes
35. Latency, without persistence, of murine cytomegalovirus in spleen and kidney
36. Immune complex effects on murine macrophages. I. Immune complexes suppress interferon-gamma induction of Ia expression
37. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction
38. oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell lines
39. Temporal regulation of murine cytomegalovirus transcription and mapping of viral RNA synthesized at immediate early times after infection
40. Molecular cloning and restriction endonuclease mapping of the murine cytomegalovirus genome (Smith strain)
41. p1B15: A cDNA clone of the rat mRNA encoding cyclophilin
42. Spliced mRNA encoding the murine cytomegalovirus chemokine homolog predicts a beta chemokine of novel structure
43. Characterization of the major immediate-early polypeptides encoded by murine cytomegalovirus
44. Immediate-early genes of murine cytomegalovirus: Location, transcripts, and translation products
45. Targeted disruption of the Stat 1 gene in mice reveals unexpected physiologic specificity of the JAK-STAT signalling pathway
46. Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes
47. Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice
48. Functional role of type I and type II interferons in antiviral defense
49. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
50. Interferon action and apoptosis are defective in mice devoid of 2′,5′-oligoadenylate-dependent RNase L
51. Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase
52. Ligand-induced IFN-gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91)
53. Microarray analysis identifies interferon-inducible genes and Stat-1 as major transcriptional targets of human papillomavirus type 31
54. Synergistic anti-HSV effect of tumor necrosis factor alpha and interferon gamma in human corneal fibroblasts is associated with interferon beta induction
55. Human gamma interferon and tumor necrosis factor exert a synergistic blockade on the replication of herpes simplex virus
56. Viral infection of macrophages profoundly alters requirements for induction of nitric oxide synthesis
57. Interferon-gamma severely inhibits DNA synthesis of vaccinia virus in a macrophage cell line
58. Gamma interferon-induced, nitric oxide-mediated inhibition of vaccinia virus replication
59. Inhibition of viral replication by interferon-gamma induced nitric oxide synthase
60. Inhibition of viral replication by nitric oxide and its reversal by ferrous sulfate and tricarboxylic acid cycle metabolites
61. Mx-dependent resistance to influenza viruses is induced by mouse interferons alpha and beta but not gamma
62. Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virus
63. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
64. Translational regulation by the interferon-induced double-stranded-RNA-activated 68kDa protein kinase
65. Suppression of rat cytomegalovirus replication by antibodies against gamma interferon
66. IFN-gamma is a prerequisite for optimal antigen processing of viral peptides in vivo
67. Murine gammaherpesvirus 68 causes large vessel arteritis in mice lacking interferon-gamma responsiveness: A new model for virus induced vascular disease
68. Interferon-gamma and tumor necrosis factor-alpha specifically induce formation of cytomegalovirus-permissive monocyte-derived macrophages that are refractory to the antiviral activity of these cytokines
69. Human cytomegalovirus inhibits IFN-alpha-stimulated antiviral and immunoregulatory responses by blocking multiple levels of IFN-alpha signal transduction
70. Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway
71. + T-cell response is mediated by repression of gamma interferon-induced class II transactivator expression
72. T cell therapy of human CMV and EBV infection in immunocompromised hosts
73. Apoptosis induced by human cytomegalovirus infection can be enhanced by cytokines to limit the spread of virus
74. Different effects of IFNgamma and IFNalpha/beta on "immediate early" gene expression of HSV-1
75. Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte
76. An essential role for type 1 interferon-gamma in teminating persistent viral infection
77. + T cells is dependent on interferon-gamma
78. A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface
79. A mouse cytomegalovirus glycoprotein retains MHC class I complexes in the ERGIC/cis-Golgi compartments
80. Presentation of CMV immediate-early antigen to cytolytic T lymphocytes is selectively prevented by viral genes expressed in the early phase
81. Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways
82. Suppression of the phenotype of gamma(1)34.5- herpes simplex virus 1: Failure of activated RNA-dependent protein kinase to shut off protein synthesis is associated with a deletion in the domain of the alpha47 gene
83. Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein
84. Repression of the interferon signal transduction pathway by the adenovirus E1A oncogene
85. Interferon-alpha inhibits the murine cytomegalovirus immediate-early gene expression by down-regulaing NF-kappaB activity
86. The interferoninducible p202 protein as a modulator of transcription: Inhibition of NF-kappa B, c-Fos, and c-Jun activities
87. The human interferon-inducible protein, IFI 16, is a repressor of transcription
88. Role of IFN-gamma-induced indoleamine 2,3 dioxygenase and inducible nitric oxide synthase in the replication of human cytomegalovirus in retinal pigment epithelial cells
89. The murine gammaherpesvirus 68 v-cyclin is an oncogene that promotes cell cycle progression in primary lymphocytes
90. The Epstein-Barr virus bZIP transcription factor Zta causes G0/G1 cell cycle arrest through induction of cyclin-dependent kinase inhibitors
91. Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription
92. Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G1 to S
93. Human cytomegalovirus inhibits cellular DNA synthesis and arrests productively infected cells in late G1
94. Cell cycle dysregulation by human cytomegalovirus: Influence of the cell cycle phase at the time of infection and effects on cyclin transcription
95. Human cytomegalovirus infection inhibits G1/S transition
96. Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest
97. Interferon gamma induces the expression of p21waf-1 and arrests macrophage cell cycle, preventing induction of apoptosis
98. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes
99. La autoantigen specifically recognizes a predicted stem-loop in hepatitis B virus RNA
100. Hepatitis B virus RNA-binding proteins associated with cytokine-induced clearance of viral RNA from the liver of transgenic mice