IFN-γ Is a Prerequisite for Optimal Antigen Processing of Viral Peptides in Vivo

Journal of Immunology

Volumn 158, Issue 7, 1997, Pages 3303-3310

  Geginat, Gernot ^a   Ruppert, Thomas ^a   Hengel, Hartmut ^a   Holtappels, Rafaela ^b   Koszinowski, Ulrich H ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOMEGALOVIRUS IMMEDIATE EARLY PHOSPHOPROTEIN PP89; GAMMA INTERFERON; IMMEDIATE EARLY PROTEIN; PEPTIDE FRAGMENT; VIRUS PROTEIN;

ANIMAL; ANTIBODY SPECIFICITY; ANTIGEN PRESENTATION; ARTICLE; BAGG ALBINO MOUSE; BETAHERPESVIRINAE; CELL LINE; HERPES VIRUS INFECTION; IMMUNOLOGY; METABOLISM; MOUSE; RADIATION CHIMERA;

ANIMALS; ANTIGEN PRESENTATION; CELL LINE, TRANSFORMED; HERPESVIRIDAE INFECTIONS; IMMEDIATE-EARLY PROTEINS; INTERFERON TYPE II; MICE; MICE, INBRED BALB C; MUROMEGALOVIRUS; ORGAN SPECIFICITY; PEPTIDE FRAGMENTS; RADIATION CHIMERA; VIRAL PROTEINS;

EID: 0031112652     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Doherty, P. C., W. Allan, M. Eichelberger, and S. R. Carding. 1992. Roles of alpha beta and gamma delta T cell subsets in viral immunity. Annu. Rev. Immunol. 10:123.
2. Ho, M. 1995. Cytomegalovirus. In Principles and Practice of Infectious Diseases. G. L. Mandell, J. E. Bennett, and R. Dolin, eds. Churchill Livingstone, New York, pp. 1351-1364.
3. Koszinowski, U. H., M. del Val, and M. J. Reddehase. 1990. Cellular and molecular basis of the protective immune response to cytomegalovirus infection. Curr. Top. Microbiol. Immunol. 154:189.
4. Riddell, S. R., K. S. Watanabe, J. M. Goodrich, C. R. Li, M. E. Agha, and P. D. Greenberg. 1992. Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones. Science 257:238.
5. Riddell, S. R., and P. D. Greenberg. 1995. Principles for adoptive therapy of human diseases. Annu. Rev. Immunol. 13:545.
6. Yang, Y., J. B. Waters, K. Fruh, and P. A. Peterson. 1992. Proteasomes are regulated by interferon gamma: implications for antigen processing. Proc. Natl. Acad. Sci. USA 89:4928.
7. Restifo, N. P., F. Esquivel, Y. Kawakami, J. W. Yewdell, J. J. Mule, S. A. Rosenberg, and J. R. Bennink. 1993. Identification of human cancers deficient in antigen processing. J. Exp. Med. 177:265.
8. Realini, C., W. Dubiel, G. Pratt, K. Ferrell, and M. Rechsteiner. 1994. Molecular cloning and expression of a gamma-interferon-inducible activator of the multicatalytic protease. J. Biol. Chem. 269:20727.
9. Gaczynska, M., K. L. Rock, and A. L. Goldberg. 1993. Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes. Nature 365:264.
10. Boes, B., H. Hengel, T. Ruppert, G. Multhaup, U. H. Koszinowski, and P. M. Kloetzel. 1994. Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes. J. Exp. Med. 179:901.
11. Ustrell, V., G. Pratt, and M. Rechsteiner. 1995. Effects of interferon gamma and major histocompatibility complex-encoded subunits on peptidase activities of human multicatalytic proteases. Proc. Natl. Acad. Sci. USA 92:584.
12. Groettrup, M., T. Ruppert, L. Kuehn, M. Seeger, U. H. Koszinowski, and P. M. Kloetzel. 1995. The interferon gamma inducible 11S regulator (PA28) changes the peptide products generated by LMP2/LMP7 modulated 20S proteasomes in vitro. J. Biol. Chem. 270:23808.
13. Groettrup, M., A. Soza, M. Eggers, L. Kuehn, T. P. Dick, H. Schild, H. G. Rammensee, U. H. Koszinowski, and P. M. Kloetzel. 1996. A role for the proteasome regulator PA28α in antigen presentation. Nature 381:166.
14. Gabathuler, R., G. Reid, G. Kolaitis, J. Driscoll, and W. A. Jefferies. 1994. Comparison of cell lines deficient in antigen presentation reveals a functional role for TAP-1 alone in antigen processing. J. Exp. Med. 180:1415.
15. David Watine, B., A. Israel, and P. Kourilsky. 1990. The regulation and expression of MHC class I genes. Immunol. Today 11:286.
16. del Val, M., H. J. Schlicht, T. Ruppert, M. J. Reddehase, and U. H. Koszinowski. 1991. Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein. Cell 66: 1145.
17. del Val, M., K. Munch, M. J. Reddehase, and U. H. Koszinowski. 1989. Presentation of CMV immediate-early antigen to cytolytic T lymphocytes is selectively prevented by viral genes expressed in the early phase. Cell 58:305.
18. Lucin, P., I. Pavic, B. Polic, S. Jonjic, and U. H. Koszinowski. 1992. Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands. J. Virol 66:1977.
19. Hengel, H., P. Lucin, S. Jonjic, T. Ruppert, and U. H. Koszinowski. 1994. Restoration of cytomegalovirus antigen presentation by gamma interferon combats viral escape. J. Virol. 68:289.
20. Rötzschke, O., K. Falk, S. Faath, and H. G. Rammensee. 1991. On the nature of peptides involved in T cell alloreactivity. J. Exp. Med. 174:1059.
21. Pamer, E. G. 1994. Direct sequence identification and kinetic analysis of an MHC class I restricted Listeria monocytogenes CTL epitope. J. Immunol. 152:686.
22. Quinnan, G. V. J., J. F. Manischewitz, and F. A. Ennis. 1978. Cytotoxic T lymphocyte response to murine cytomegalovirus infection. Nature 273:541.
23. + T lymphocytes. J. Exp. Med. 169:1199.
24. Woodward, J. G., B. L. Shigekawa, and J. A. Frelionger. 1982. Bone marrow derived cells are responsible for stimulating I region-incompatible skin graft rejection. Transplantation 33:254.
25. Bale, J. F. J., M. E. O'Neil, R. Giller, S. Perlman, and U. Koszinowski. 1987. Murine cytomegalovirus genomic material in marrow cells: relation to altered leukocyte counts during sublethal infection of mice. J. Infect. Dis. 155:207.
26. Trinchieri, G., and B. Perussia. 1985. Immune interferon: a pleiotropic lymphokine with multiple effects. Immunol. Today 6:131.
27. Koszinowski, U. H., G. M. Keil, H. Schwarz, J. Schickedanz, and M. J. Reddehase. 1987. A nonstructural polypeptide encoded by immediate-early transcription unit 1 of murine cytomegalovirus is recognized by cytolytic T lymphocytes. J. Exp. Med. 166:289.
28. del Val, M., H. Hengel, H. Hacker, U. Hartlaub, T. Ruppert, P. Lucin, and U. H. Koszinowski. 1992. Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment. J. Exp. Med. 176:729.
29. Smith, J. D., N. B. Myers, J. Gorka, and T. H. Hansen. 1993. Model for the in vivo assembly of nascent Ld class I molecules and for the expression of unfolded Ld molecules at the cell surface. J. Exp. Med. 178:2035.
30. Villanueva, M. S., P. Fischer, K. Feen, and E. G. Pamer. 1994. Efficiency of MHC class I antigen processing: a quantitative analysis. Immunity 1:479.
31. Mocarski, E. S. J., G. B. Abenes, W. C. Manning, L. C. Sambucetti, and J. M. Cherrington. 1990. Molecular genetic analysis of cytomegalovirus gene regulation in growth, persistence and latency. Curr. Top. Microbiol. Immunol. 154:47.
32. Rötzschke, O., K. Falk, K. Deres, H. Schild, M. Norda, J. Metzger, G. Jung, and H. G. Rammensee. 1990. Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells. Nature 348:252.
33. Griem, P., H. J. Wallny, K. Falk, O. Rötzschke, B. Arnold, G. Schonrich, G. Hammerling, and H. G. Rammensee. 1991. Uneven tissue distribution of minor histocompatibility proteins versus peptides is caused by MHC expression. Cell 65:633.
34. Kundig, T. M., M. F. Bachmann, C. DiPaolo, J. L. Simard, M. Battegay, H. Lother, A. Gessner, K. Külcke, P. S. Ohashi, H. Hengartner, and R. M. Zinkernagel. 1995. Fibroblasts as efficient antigen-presenting cells in lymphoid organs. Science 268:1343.
35. Loh, J. E., C. H. Chang, W. L. Fodor, and R. A. Flavell. 1992. Dissection of the Interferon gamma-MHC class II signal transduction pathway reveals that type I and type II interferon systems share common signalling component(s). EMBO J. 11:1351.
36. Kimura, T., K. Nakayama, J. Penninger, M. Kitagawa, H. Harada, T. Matsuyama, N. Tanaka, R. Kamijo, J. Vilcek, T. W. Mak, and T. Taniguchi. 1994. Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science 264:1921.
37. Wong, G. H., and D. V. Goeddel. 1986. Tumour necrosis factors alpha and beta inhibit virus replication and synergize with interferons. Nature 323:819.
38. Schijns, V. E., R. Van der Neut, B. L. Haagmans, D. R. Bar, H. Schellekens, and M. C. Horzinek. 1991. Tumour necrosis factor-alpha, interferon-gamma and interferon-beta exert antiviral activity in nervous tissue cells. J. Gen. Virol. 72:809.
39. Lucin, P., S. Jonjic, M. Messerle, B. Polic, H. Hengel, and U. H. Koszinowski. 1994. Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor. J. Gen. Virol. 75:101.
40. Scott, P. 1991. IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis. J. Immunol. 147:3149.
41. + T cell response. J. Exp. Med. 181:961.
42. Akiyama, K., K. Yokota, S. Kagawa, N. Shimbara, T. Tamura, H. Akioka, H. G. Nothwang, C. Noda, K. Tanaka, and A. Ichihara. 1994. cDNA cloning and interferon gamma down-regulation of proteasomal subunits X and Y. Science 265: 1231.
43. Klavinskis, L. S., R. Geckeler, and M. B. Oldstone. 1989. Cytotoxic T lymphocyte control of acute lymphocytic choriomeningitis virus infection: interferon gamma, but not tumour necrosis factor alpha, displays antiviral activity in vivo. J. Gen. Virol. 70:3317.
44. Huang, S., W. Hendriks, A. Althage, S. Hemmi, H. Bluethmann, R. Kamijo, J. Vilcek, R. M. Zinkernagel, and M. Aguet. 1993. Immune response in mice that lack the interferon-gamma receptor. Science 259:1742.
45. Graham, M. B., D. K. Dalton, D. Giltinan, V. L. Braciale, T. A. Stewart, and T. J. Braciale. 1993. Response to influenza infection in mice with a targeted disruption in the interferon gamma gene. J. Exp. Med. 178:1725.
46. Beersma, M. F. C., M. J. E. Bulmakers, and H. L. Ploegh. 1993. Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains. J. Immunol. 151:4455.
47. Hengel, H., C. Esslinger, J. Pool, E. Goulmy, and U. H. Koszinowski. 1995. Cytokines restore MHC class I complex formation and control antigen presentation in human cytomegalovirus-infected cells. J. Gen. Virol. 76:2987.
48. Thäle, R., U. Szepan, H. Hengel, G. Geginat, P. Lucin, and U. H. Koszinowski. 1995. Identification of the mouse cytomegalovirus genomic region affecting MHC class I molecule transport. J. Virol. 69:6098.
49. Jones, T. R., L. K. Hanson, L. Sun, J. S. Slater, R. M. Stenberg, and A. E. Campbell. 1995. Multiple independent loci within the human cytomegalovirus unique short region down-regulate expression of major histocompatibility complex class I heavy chains. J. Virol. 69:4830.
50. Hengel, H., T. Flohr, G. J. Hammerling, U. H. Koszinowski, and F. Momburg. 1996. Human cytomegalovirus inhibits peptide translocation into the endoplasmic reticulum for MHC class I assembly. J. Gen. Virol. 77:2282.
51. Reddehase, M. J., W. Mutter, and U. H. Koszinowski. 1987. In vivo application of recombinant interleukin 2 in the immunotherapy of established cytomegalovirus infection. J. Exp. Med. 165:650.