Biaryl ether retrohydroxamates as potent, long-lived, orally bioavailable MMP inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 12, 2001, Pages 1553-1556

  Michaelides, Michael R ^a   Dellaria, Joseph F ^a   Gong, Jane ^a   Holms, James H ^a   Bouska, Jennifer J ^a   Stacey, Jamie ^a   Wada, Carol K ^a   Heyman, H Robin ^a   Curtin, Michael L ^a   Guo, Yan ^a   Goodfellow, Carole L ^a   Elmore, Ildiko B ^a   Albert, Daniel H ^a   Magoc, Terrance J ^a   Marcotte, Patrick A ^a   Morgan, Douglas W ^a   Davidsen, Steven K ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; ANTINEOPLASTIC AGENT; CIPEMASTAT; DRUG METABOLITE; ETHER HYDROXAMATE DERIVATIVE; ETHER RETROHYDROXAMATE DERIVATIVE; HYDANTOIN DERIVATIVE; HYDROXAMIC ACID DERIVATIVE; MATRIX METALLOPROTEINASE INHIBITOR; PHTHALIMIDE DERIVATIVE; PYRIDAZINONE DERIVATIVE; REBIMASTAT; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; IC 50; MONKEY; NONHUMAN; RAT; REACTION ANALYSIS; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL AVAILABILITY; ENZYME INHIBITORS; HALF-LIFE; HYDROXAMIC ACIDS; INHIBITORY CONCENTRATION 50; INJECTIONS, INTRAVENOUS; MACACA FASCICULARIS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASES;

EID: 0035907471     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00031-2     Document Type: Article

References (10)