N-formyl hydroxylamine containing dipeptides: Generation of a new class of vasopeptidase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 3, 2000, Pages 257-260

  Robl, Jeffrey A ^a   Simpkins, Ligaya M ^a   Asaad, Magdi M ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENKEPHALINASE INHIBITOR; HYDROXAMIC ACID; HYDROXYLAMINE; METALLOPROTEINASE INHIBITOR; N FORMYL HYDROXYLAMINE; PHOSPHORUS ACID DERIVATIVE; THIOL DERIVATIVE; UNCLASSIFIED DRUG; VASOPEPTIDASE INHIBITOR; ZINC DERIVATIVE;

ARTICLE; CHEMICAL MODIFICATION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; INHIBITION KINETICS; STEREOCHEMISTRY;

DIPEPTIDES; HYDROXYLAMINES; METALLOENDOPEPTIDASES;

EID: 0034615061     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00671-X     Document Type: Article

References (23)

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22. Compounds 12a and 12d were described in references 10a and 10b respectively. Compound 12b was reported in Robl, J. A.; Sulsky, R.; Sieber-McMaster, E.; Ryono, D. E.; Cimarusti, M. P.; Simpkins, L. M.; Karanewsky, D. S.; Chao, S.; Asaad, M. M.; Seymour, A. A.; Fox, M.; Smith, P. L.; Trippodo, N. C. J. Med. Chem. 1999, 42, 305. Compound 12c was described in Flynn, G. A.; Beight, D. W.; Mehdi, S.; Koehl, J. R.; Giroux, E. L.; French, J. F.; Hake, P. W.; Dage, R. C. J. Med. Chem. 1993, 36, 2420.
23. Compounds 12a and 12d were described in references 10a and 10b respectively. Compound 12b was reported in Robl, J. A.; Sulsky, R.; Sieber-McMaster, E.; Ryono, D. E.; Cimarusti, M. P.; Simpkins, L. M.; Karanewsky, D. S.; Chao, S.; Asaad, M. M.; Seymour, A. A.; Fox, M.; Smith, P. L.; Trippodo, N. C. J. Med. Chem. 1999, 42, 305. Compound 12c was described in Flynn, G. A.; Beight, D. W.; Mehdi, S.; Koehl, J. R.; Giroux, E. L.; French, J. F.; Hake, P. W.; Dage, R. C. J. Med. Chem. 1993, 36, 2420.