Discovery and characterization of the potent, selective and orally bioavailable MMP inhibitor ABT-770

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 12, 2001, Pages 1557-1560

  Curtin, Michael L ^a   Florjancic, Alan S ^a   Heyman, H Robin ^a   Michaelides, Michael R ^a   Garland, Robert B ^a   Holms, James H ^a   Steinman, Douglas H ^a   Dellaria, Joseph F ^a   Gong, Jane ^a   Wada, Carol K ^a   Guo, Yan ^a   Elmore, Ildiko B ^a   Tapang, Paul ^a   Albert, Daniel H ^a   Magoc, Terrance J ^a   Marcotte, Patrick A ^a   Bouska, Jennifer J ^a   Goodfellow, Carole L ^a   Bauch, Joy L ^a   Marsh, Kennan C ^a   Morgan, Douglas W ^a   Davidsen, Steven K ^a   more..

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABT 770; ANTINEOPLASTIC AGENT; GELATINASE A; GELATINASE INHIBITOR; INTERSTITIAL COLLAGENASE; PACLITAXEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; MONKEY; MOUSE; NONHUMAN; RAT; REACTION ANALYSIS; SKIN CANCER; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TUMOR GROWTH;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; BIPHENYL COMPOUNDS; CELL DIVISION; DOGS; ENZYME INHIBITORS; HALF-LIFE; HAPLORHINI; HYDROXAMIC ACIDS; INHIBITORY CONCENTRATION 50; INJECTIONS, INTRAVENOUS; MATRIX METALLOPROTEINASES; METABOLIC CLEARANCE RATE; NEOPLASMS, EXPERIMENTAL; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0035907474     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00032-4     Document Type: Article

References (10)