CD28-B7 T cell costimulatory blockade by CTLA4Ig in the rat renal allograft model: Inhibition of cell-mediated and humoral immune responses in vivo

Transplantation

Volumn 62, Issue 12, 1996, Pages 1942-1945

  Akalin, Enver ^b   Chandraker, Anil ^b   Russell, Mary E ^b   Turka, Laurence A ^b   Hancock, Wayne W ^b   Sayegh, Mohamed H ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; LYMPHOCYTE ANTIBODY;

ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; IMMUNOLOGICAL TOLERANCE; KIDNEY ALLOGRAFT; KIDNEY ALLOGRAFT REJECTION; KIDNEY TRANSPLANTATION; LYMPHOCYTE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE;

ANIMALS; ANTIBODY FORMATION; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, DIFFERENTIATION; GRAFT SURVIVAL; IMMUNITY, CELLULAR; IMMUNOCONJUGATES; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MALE; RATS; RATS, INBRED BN; RATS, INBRED LEW; RATS, INBRED WF; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS;

EID: 0030461047     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199612270-00047     Document Type: Conference Paper

References (10)

1. Sayegh MH, Turka LA. T cell costimulatory pathways: promising novel targets for immunosuppression and tolerance induction. J Am Soc Nephrol 1995; 6: 1143.
2. Sayegh MH, Akalin E, Hancock WW, Russell ME, Carpenter CB, Turka LA. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med 1995; 181: 1869.
3. Sayegh MH, Sablinski T, Tananka K, et al. Effects of BWH-4 anti-CD4 monoclonal antibody on rat vascularized cardiac allografts before and after engraftment. Transplantation 1991; 51: 296.
4. Sayegh MH, Kut JP, Milford EL. Anti-CD4 monoclonal antibody (BWH-4) effects cellular hyporesponsiveness and prolongs renal allograft survival in the rat. Hum Immunol 1989; 26: 131.
5. Russell ME, Hancock WW, Akalin E, et al. Chronic cardiac rejection in the Lewis to F344 rat model: blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis. J Clin Invest 1996; 97: 833.
6. Judge TA, Tang A, Spain LM, Gratiot-Deans J, Sayegh MH, Turka LA. The in vivo mechanisms of action of CTLA4Ig. J Immunol 1996; 156: 2294.
7. Khoury SJ, Akalin A, Chandraker A, et al. CD28-B7 blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system. J Immunol 1995; 155: 4521.
8. Nadeau KC, Azuma H, Tilney NL. Sequential cytokine dynamics in chronic rejection of rat renal allografts: key roles for RANTES and MCP-1. Proc Natl Acad Sci USA 1995; 92: 8729.
9. Sharma V, Bologa RM, Xu G-P, et al. Intragraft TGF-β1 mRNA: a correlate of interstitial fibrosis and chronic allograft nephropathy. Kidney Int 1996; 49: 1297.
10. Larsen CP, Alexander DZ, Hollenbaugh D, et al. CD40-gp39 interactions play a critical role during allograft rejection: suppression of allograft rejection by blockade of the CD40-gp39 pathway. Transplantation 1996; 61: 4.