The cis requirements for transcriptional activation by HilA, a virulence determinant encoded on SPI-1

Molecular Microbiology

Volumn 37, Issue 2, 2000, Pages 300-315

  Lostroh, C Phoebe ^a   Bajaj, Vivek ^a   Lee, Catherine A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; ESCHERICHIA COLI; GENE DELETION; GENE MUTATION; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; SALMONELLA TYPHIMURIUM; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

BACTERIAL PROTEINS; BASE SEQUENCE; BLOTTING, WESTERN; DNA-BINDING PROTEINS; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS (GENETICS); SALMONELLA TYPHIMURIUM; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; VIRULENCE;

EID: 0033929352     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2000.01991.x     Document Type: Article

References (50)

1. Ahmer, B.M., and Heffron, F. (1999) Salmonella typhimurium recognition of intestinal environments: response. Trends Microbiol 7: 222-223.
2. Aoyama, T., and Oka, A. (1990) A common mechanism of transcriptional activation by the three positive regulators, VirG, PhoB, and OmpR. FEBS Lett 263: 1-4.
3. Bajaj, V., Hwang, C., and Lee, C.A. (1995) hilA is a novel ompR/toxR family member that activates the expression of Salmonella typhimurium invasion genes. Mol Microbiol 18: 715-727.
4. Bajaj, V., Lucas, R.L., Hwang, C., and Lee, C.A. (1996) Coordinate regulation of Salmonella typhimurium invasion genes by environmental and regulatory factors is mediated by control of hilA expression. Mol Microbiol 22: 703-714.
5. Baumler, A.J., Tsolis, R.M., Ficht, T.A., and Adams, L.G. (1998) Evolution of host adaptation in Salmonella enterica. Infect Immun 66: 4579-4587.
6. Behlau, I., and Miller, S.I. (1993) A PhoP-repressed gene promotes Salmonella typhimurium invasion of epithelial cells. J Bacteriol 175: 4475-4484.
7. + for all three chromosomally located systems of DNA restriction and modification. J Bact 156: 471-474.
8. Busby, S., and Ebright, R.H. (1999) Transcription activation by catabolite activator protein (CAP). J Mol Biol 293: 199-213.
9. Carlson, S.A., and Jones, B.D. (1998) Inhibition of Salmonella typhimurium invasion by host cell expression of secreted bacterial invasion proteins. Infect Immun 66: 5295-5300.
10. Chang, A.C., and Cohen, S.N. (1978) Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. J Bacteriol 134: 1141-1156.
11. Collazo, C.M., and Galan, J.E. (1997) The invasion-associated type-III protein secretion system in Salmonella - a review. Gene 192: 51-59.
12. Crawford, J.A., Kaper, J.B., and DiRita, V.J. (1998) Analysis of ToxR-dependent transcription activation of ompU, the gene encoding a major envelope protein in Vibrio cholerae. Mol Microbiol 29: 235-246.
13. Csonka, L.N., and Hanson, A.D. (1991) Prokaryotic osmoregulation: genetics and physiology. Annu Rev Microbiol 45: 569-606.
14. Darwin, K.H., and Miller, V.L. (1999a) InvF is required for expression of genes encoding proteins secreted by the SPI1 type III secretion apparatus in Salmonella typhimurium. J Bacteriol 181: 4949-4954.
15. Darwin, K.H., and Miller, V.L. (1999b) Molecular basis of the interaction of Salmonella with the intestinal mucosa. Clin Microbiol Rev 12: 405-428.
16. Darwin, K.H., and Miller, V.L. (2000) The putative invasion protein chaperone SicA acts together with InvF to activate the expression of Salmonella typhimurium virulence genes. Mol Microbiol 35: 949-960.
17. Eichelberg, K., Hardt, W.D., and Galan, J.E. (1999) Characterization of SprA, an AraC-like transcriptional regulator encoded within the Salmonella typhimurium pathogenicity island 1. Mol Microbiol 33: 139-152.
18. Finlay, B.B., Ruschkowski, S., and Dedhar, S. (1991) Cytoskeletal rearrangements accompanying salmonella entry into epithelial cells. J Cell Sci 99: 283-296.
19. Forst, S.A., and Roberts, D.L. (1994) Signal transduction by the EnvZ-OmpR phosphotransfer system in bacteria. Res Microbiol 145: 363-373.
20. Fu, Y., and Galan, J.E. (1998) The Salmonella spp. protein tyrosine phosphatase SptP is translocated into host cells and disrupts the host-cell cytoskeleton. Mol Microbiol 27: 259-368.
21. 2+ as an extracellular signal: environmental regulation of Salmonella virulence. Cell 84: 165-174.
22. Gewirtz, A.T., Siber, A.M., Madara, J.L., and McCormick, B.A. (1999) Orchestration of neutrophil movement by intestinal epithelial cells in response to Salmonella typhimurium can be uncoupled from bacterial internalization. Infect Immun 67: 608-617.
23. Groisman, E.A., and Ochman, H. (1997) How Salmonella became a pathogen. Trends Microbiol 5: 343-349.
24. Gunn, J.S., Hohmann, E.L., and Miller, S.I. (1996) Transcriptional regulation of Salmonella virulence: a PhoQ periplasmic domain mutation results in increased net phosphotransfer to PhoP. J Bacteriol 178: 6369-6373.
25. Haldimann, A., Daniels, L.L., and Wanner, B.L. (1998) Use of new methods for construction of tightly regulated arabinose and rhamnose promoter fusions in studies of the Escherichia coli phosphate regulon. J Bacteriol 180: 1277-1286.
26. Hardt, W.D., Urlaub, H., and Galan, J.E. (1998) S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells. Cell 93: 815-826.
27. Harrison-McMonagle, P., Denissova, N., Martinez-Hackert, E., Ebright, R.H., and Stock, A.M. (1999) Orientation of OmpR monomers within an OmpR: DNA complex determined by DNA affinity cleaving. J Mol Biol 285: 555-566.
28. Hersh, D., Monack, D.M., Smith, M.R., Ghori, N., Falkow, S., and Zychlinsky, A. (1999) The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1. Proc Natl Acad Sci USA 96: 2396-2401.
29. Hochschild, A., and Dove, S.L. (1998) Protein-protein contacts that activate and repress prokaryotic transcription. Cell 92: 597-600.
30. Hoiseth, S.K., and Stocker, B.A. (1981) Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines. Nature 291: 238-239.
31. Hueck, C.J. (1998) Type III protein secretion systems in bacterial pathogens of animals and plants. Microbiol Mol Biol Rev 62: 379-433.
32. Hueck, C.J., Hantman, M.J., Bajaj, V., Johnston, C., Lee, C.A., and Miller, S.I. (1995) Salmonella typhimurium secreted invasion determinants are homologous to Shigella Ipa proteins. Mol Microbiol 18: 479-90.
33. Johnston, C., Pegues, D.A., Hueck, C.J., Lee, A., and Miller, S.I. (1996) Transcriptional activation of Salmonella typhimurium invasion genes by a member of the phosphorylated response-regulator superfamily. Mol Microbiol 22: 715-727.
34. Jones, B., Pascopella, L., and Falkow, S. (1995) Entry of microbes into the host: using M cells to break the mucosal barrier. Curr Opin Immunol 7: 474-478.
35. Lee, C.A., and Jones, B.D., and Falkow, S. (1992) Identification of a Salmonella typhimurium invasion locus by selection for hyperinvasive mutants. Proc Natl Acad Sci USA 89: 1847-1851.
36. Lodge, J., Fear, J., Busby, S., Gunasekaran, P., and Kamini, N.R. (1992) Broad host range plasmids carrying the Escherichia coli lactose and galactose operons. FEMS Microbiol Lett 74: 271-276.
37. Lucas, R.L., Lostroh, C.P., DiRusso, C.C., Spector, M.P., Wanner, B.L., and Lee, C.A. (2000) Multiple factors independently regulate hilA and invasion gene expression in Salmonella enterica serovar Typhimurium. J Bacteriol 182: 1872-1882.
38. Martinez-Hackert, E., and Stock, A.M. (1997) Structural relationships in the OmpR family of winged-helix transcription factors. J Mol Biol 269: 301-312.
39. Miller, J.H. (1972) Experiments in Molecular Genetics. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
40. Miller, V.L., Taylor, R.K., and Mekalanos, J.J. (1987) Cholera toxin transcriptional activator toxR is a transmembrane DNA binding protein. Cell 48: 271-279.
41. Mills, D.M., Bajaj, V., and Lee, C.A. (1995) A 40 kb chromosomal fragment encoding Salmonella typhimurium invasion genes is absent from the corresponding region of the Escherichia coli K-12 chromosome. Mol Microbiol 15: 749-759.
42. Mills, S.D., Jasalavich, C.A., and Cooksey, D.A. (1993) A two-component regulatory system required for copper-inducible expression of the copper resistance operon of Pseudomonas syringae. J Bacteriol 175: 1656-1664.
43. Pegues, D.A., Hantman, M.J., Behlau, I., and Miller, S.I. (1995) PhoP/PhoQ transcriptional repression of Salmonella typhimurium invasion genes: evidence for a role in protein secretion. Mol Microbiol 17: 169-181.
44. Rakeman, J.L., Bonifield, H.R., and Miller, S.I. (1999) A HilA-independent pathway to Salmonella typhimurium invasion gene transcription. J Bacteriol 181: 3096-3104.
45. Schechter, L.M., Damrauer, S.M., and Lee, C.A. (1999) Two AraC/XylS family members can independently counteract the effect of repressing sequences upstream of the hilA promoter. Mol Microbiol 32: 629-642.
46. Spee, J.H., de Vos, W.M., and Kuipers, O.P. (1993) Efficient random mutagenesis method with adjustable mutation frequency by use of PCR and dITP. Nucleic Acids Res 21: 777-778.
47. Stibitz, S., Black, W., and Falkow, S. (1986) The construction of a cloning vector designed for gene replacement in Bordetella pertussis. Gene 50: 133-140.
48. Takeuchi, A. (1967) Electron microscope studies of experimental Salmonella infection. I. Penetration into the intestinal epithelium by Salmonella typhimurium. Am J Pathol 50: 109-136.
49. Woodcock, D.M., Crowther, P.J., Doherty, J., Jefferson, S., DeCruz, E., Noyer-Weidner, M., et al. (1989) Quantitative evaluation of Escherichia coli host strains for tolerance to cytosine methylation in plasmid and phage recombinants. Nucleic Acids Res 17: 3469-3478.
50. R. J Mol Biol 229: 37-51.