Two AraC/XylS family members can independently counteract the effect of repressing sequences upstream of the hilA promoter

Molecular Microbiology

Volumn 32, Issue 3, 1999, Pages 629-642

  Schechter, Lisa M ^a   Damrauer, Scott M ^a   Lee, Catherine A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXYGEN;

ARTICLE; EPITHELIUM CELL; GENE EXPRESSION; GENE ISOLATION; GENE REPRESSION; GENE SEQUENCE; GENETIC TRANSCRIPTION; NONHUMAN; NUCLEOTIDE SEQUENCE; OSMOLARITY; PATHOGENICITY; PRIORITY JOURNAL; PROMOTER REGION; SALMONELLA ENTERICA; SALMONELLA TYPHIMURIUM; SMALL INTESTINE;

ARAC TRANSCRIPTION FACTOR; BACTERIAL PROTEINS; BASE SEQUENCE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; MOLECULAR SEQUENCE DATA; MUTATION; PROMOTER REGIONS (GENETICS); REGULATORY SEQUENCES, NUCLEIC ACID; REPRESSION; REPRESSOR PROTEINS; SALMONELLA TYPHIMURIUM; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

SALMONELLA ENTERICA; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0032903582     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1999.01381.x     Document Type: Article

References (66)

1. Ahmer, B.M.M., van Reeuwijk, J., Watson, P.R., Wallis, T.S., and Heffron, F. (1999) Salmonella SirA is a global regulator of genes mediating enteropathogenesis. Mol Microbiol 31: 971-982.
2. Alekshun, M.N., and Levy, S.B. (1997) Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon. Antimicrob Agents Chemother 41: 2067-2075.
3. Altschul, S.F., Madden, T.L., Schaffer, A.A., Zhang, J., Zhang, Z., Miller, W., et al. (1997) Gapped Blast and Psi-Blast: a new generation of protein database search programs. Nucleic Acids Res 25: 3389-3402.
4. Arricau, N., Hermant, D., Waxin, H., Ecobichon, C., Duffey, P.S., and Popoff, M.Y. (1998) The RcsB-RcsC regulatory system of Salmonella typhi differentially modulates the expression of invasion proteins, flagellin and Vi antigen in response to osmolarity. Mol Microbiol 29: 835-850.
5. Atlung, T., and Ingmer, H. (1997) H-NS: a modulator of environmentally regulated gene expression. Mol Microbiol 24: 7-17.
6. Bajaj, V., Hwang, C., and Lee, C.A. (1995) hilA is a novel ompR/toxR family member that activates the expression of Salmonella typhimurium invasion genes. Mol Microbiol 18: 715-727.
7. Bajaj, V., Lucas, R.L., Hwang, C., and Lee, C.A. (1996) Coordinate regulation of Salmonella typhimurium invasion genes by environmental and regulatory factors is mediated by control of hilA expression. Mol Microbiol 22: 703-714.
8. Behlau, I., and Miller, S.I. (1993) A PhoP-repressed gene promotes Salmonella typhimurium invasion of epithelial cells. J Bacteriol 175: 4475-4484.
9. Carmona, M., Balsalobre, C., Muñoa, F., Mouriño, M., De Jubete, Y., la Cruz, F., et al. (1993) Escherichia coli hha mutants, DNA supercoiling and expression of the haemolysin genes from the recombinant plasmid pANN202-312. Mol Microbiol 9: 1011-1018.
10. Carroll, P.A., Tashima, K.T., Rogers, M.B., DiRita, V.J., and Calderwood, S.B. (1997) Phase variation in tcpH modulates expression of the ToxR regulon in Vibrio cholerae. Mol Microbiol 25: 1099-1111.
11. Chen, L.-M., Kaniga, K., and Galán, J.E. (1996) Salmonella spp. are cytotoxic for cultured macrophages. Mol Microbiol 21: 1101-1115.
12. Cirillo, D.M., Valdivia, R.H., Monack, D.M., and Falkow, S. (1998) Macrophage-dependent induction of the Salmonella pathogenicity island 2 type III secretion system and its role in intracellular survival. Mol Microbiol 30: 175-188.
13. Collazo, C.M., and Galán, J.E. (1997) The invasion-associated type-III protein secretion system in Salmonella - a review. Gene 192: 51-59.
14. Cornelis, G.R., Sluiters, C., Delor, I., Geib, D., Kaniga, K., Lambert de Rouvroit, C., et al. (1991) ymoA, a Yersinia enterocolitica chromosomal gene modulating the expression of virulence functions. Mol Microbiol 5: 1023-1034.
15. Deiwick, J., Nikolaus, T., Shea, J.E., Gleeson, C., Holden, D.W., and Mensel, M. (1998) Mutations in Salmonella pathogenicity island 2 (SPI2) genes affecting transcription of SPI1 genes and resistance to antimicrobial agents. J Bacteriol 180: 4775-4780.
16. Eichelberg, K., Kaniga, K., and Galán, J.E. (1996) Transcriptional regulation of Salmonella secreted virulence determinants. In The 96th General Meeting of the American Society for Microbiology New Orleans. Washington, DC: American Society for Microbiology Press, p. 161.
17. Eichelberg, K., Hardt, W.-D., and Galán, J.E. (1998) Identification and characterization of the S. typhimurium transcriptional regulators SprA and SprB encoded in SPI1. In The 98th General Meeting of the American Society for Microbiology Atlanta. Washington, DC: American Society for Microbiology Press, p. 74.
18. Falconi, M., Higgins, N.P., Spurio, R., Pon, C.L., and Gualerzi, C.O. (1993) Expression of the gene encoding the major bacterial nucleoid protein H-NS is subject to transcriptional autorepression. Mol Microbiol 10: 273-282.
19. Finlay, B.B., and Falkow, S. (1997) Common themes in microbial pathogenicity revisited. Microbiol Mol Biol Rev 61: 136-169.
20. Fu, Y., and Galán, J.E. (1998) The Salmonella typhimurium tyrosine phosphatase SptP is translocated into host cells and disrupts the actin cytoskeleton. Mol Microbiol 27: 359-368.
21. Galán, J.E., and Curtiss, III, R. (1990) Expression of Salmonella typhimurium genes required for invasion is regulated by changes in DNA supercoiling. Infect Immun 58: 1879-1885.
22. Gallegos, M.-T., Schleif, R., Bairoch, A., Hofmann, K., and Ramos, J.L. (1997) AraC/XylS family of transcriptional regulators. Microbiol Mol Biol Rev 61: 393-410.
23. García Véscovi, E., Soncini, F.C., and Groisman, E.A. (1996) Mg2+ as an extracellular signal: environmental regulation of Salmonella virulence. Cell 84: 165-174.
24. Gottesman, S. (1995) Regulation of capsule biosynthesis: Modification of the two-component paradigm by an accessory unstable regulator. In Two-Component Signal Transduction. Hoch, J.A., and Silhavy, T.J. (eds). Washington, DC: American Society for Microbiology Press, pp. 253-262.
25. 2+ as a regulatory signal. Bioessays 20: 96-101.
26. Gunn, J.S., Hohmann, E.L., and Miller, S.I. (1996) Transcriptional regulation of Salmonella virulence: a PhoQ periplasmic domain mutation results in increased net phosphotransfer to PhoP. J Bacteriol 178: 6369-6373.
27. Hamilton, C.M., Aldea, M., Washburn, B.K., Babitzke, P., and Kushner, S.R. (1989) New method for generating deletions and gene replacements in Escherichia coli. J Bacteriol 171: 4617-4622.
28. Hardt, W.-D., Chen, L.-M., Schuebel, K.E., Bustelo, X.R., and Galán, J.E. (1998) S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells. Cell 93: 815-826.
29. Hardt, W.-D., and Galán, J.E. (1997) A secreted Salmonella protein with homology to an avirulence determinant of plant pathogenic bacteria. Proc Natl Acad Sci USA 94: 9887-9892.
30. Häse, C.C., and Mekalanos, J.J. (1998) TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae. Proc Natl Acad Sci USA 95: 730-734.
31. Hensel, M., Shea, J.E., Waterman, S.R., Mundy, R., Nikolaus, T., Banks, G., et al. (1998) Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages. Mol Microbiol 30: 163-174.
32. Hoiseth, S.K., and Stocker, B.A, (1981) Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines. Nature 291: 238-239.
33. Hueck, C.J. (1998) Type III protein secretion systems in bacterial pathogens of animals and plants. Microbiol Mol Biol Rev 62: 379-433.
34. Hueck, C.J., Hantman, M.J., Bajaj, V., Johnston, C., Lee, C.A., and Miller, S.I. (1995) Salmonella typhimurium secreted invasion determinants are homologous to Shigella Ipa proteins. Mol Microbiol 18: 479-490.
35. Johnston, C., Pegues, D.A., Hueck, C.J., Lee, A., and Miller, S.I. (1996) Transcriptional activation of Salmonella typhimurium invasion genes by a member of the phosphorylated response-regulator superfamily. Mol Microbiol 22: 715-727.
36. Jones, B.D., Lee, C.A., and Falkow, S. (1992) Invasion by Salmonella typhimurium is affected by the direction of flagellar rotation. Infect Immun 60: 2475-2480.
37. Jones, B., Pascopella, L., and Falkow, S. (1995) Entry of microbes into the host: using M cells to break the mucosal barrier. Curr Opin Immunol 7: 474-478.
38. Jordi, B.J.A.M., Dagberg, B., de Haan, L.A.M., Hamers, A.M., van der Zeijst, B.A.M., Gaastra, W., et al. (1992) The positive regulator CfaD overcomes the repression mediated by histone-like proteins H-NS (H1) in the CFA/I fimbrial operon of Escherichia coli. EMBO J 11: 2627-2632.
39. Kaniga, K., Bossio, J.C., and Galán, J.E. (1994) The Salmonella typhimurium invasion genes invF and invG encode homologues of the AraC and PuID family of proteins. Mol Microbiol 13: 555-568.
40. Kaniga, K., Uralil, J., Bliska, J.B., and Galán, J.E. (1996) A secreted protein tyrosine phosphatase with modular effector domains in the bacterial pathogen Salmonella typhimurium. Mol Microbiol 21: 633-641.
41. Lambert de Rouvroit, C., Sluiters, C., and Cornelis, G.R. (1992) Role of the transcriptional activator, VirF, and temperature in the expression of the pYV plasmid genes of Yersinia enterocolitica. Mol Microbiol 6: 395-409.
42. Lee, C.A. (1997) Type III secretion systems: machines to deliver bacterial proteins into eukaryotic cells. Trends Microbiol 5: 148-156.
43. Lee, C.A., and Falkow, S. (1990) The ability of Salmonella to enter mammalian cells is affected by bacterial growth state. Proc Natl Acad Sci USA 87: 4304-4308.
44. Lee, C.A., Jones, B.D., and Falkow, S. (1992) Identification of a Salmonella typhimurium invasion locus by selection for hyperinvasive mutants. Proc Natl Acad Sci USA 89: 1847-1851.
45. Link, A.J., Phillips, D., and Church, G.M. (1997) Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: application to open reading frame characterization. J Bacteriol 179: 6228-6237.
46. Lodge, J., Fear, J., Busby, S., Gunasekaran, P., and Kamini, N.R. (1992) Broad host range plasmids carrying the Escherichia coli lactose and galactose operons. FEMS Microbiol Lett 95: 271-276.
47. Lupas, A. (1996) Prediction and analysis of coiled-coil structures. Methods Enzymol 266: 513-524.
48. McCormick, B.A., Miller, S.I., Carnes, D., and Madara, J.L. (1995) Transepithelial signaling to neutrophils by salmonellae: a novel virulence mechanism for gastroenteritis. Infect Immun 63: 2302-2309.
49. Miller, J.H. (1992) A Short Course in Bacterial Genetics. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
50. Mills, D.M., Bajaj, V., and Lee, C.A. (1995) A 40 kb chromosomal fragment encoding Salmonella typhimurium invasion genes is absent from the corresponding region of the Escherichia coli K-12 chromosome. Mol Microbiol 15: 749-759.
51. Monack, D.M., Raupach, B., Hromockyj, A.E., and Falkow, S. (1996) Salmonella typhimurium invasion induces apoptosis in infected macrophages. Proc Natl Acad Sci USA 93: 9833-9838.
52. Nieto, J.M., Carmona, M., Bolland, S., de Jubete, Y., la Cruz, F., and Juárez, A. (1991) The hha gene modulates haemolysin expression in Escherichia coli. Mol Microbiol 5: 1285-1293.
53. Ochman, H., Soncini, F.C., Solomon, F., and Groisman, E.A. (1996) Identification of a pathogenicity island required for Salmonella survival in host cells. Proc Natl Acad Sci USA 93: 7800-7804.
54. Pegues, D.A., Hantman, M.J., Behlau, I., and Miller, S.I. (1995) PhoP/PhoQ transcriptional repression of Salmonella typhimurium invasion genes: evidence for a role in protein secretion. Mol Microbiol 17: 169-181.
55. Rich, J.J., Kinscherf, T.G., Kitten, T., and Willis, D.K. (1994) Genetic evidence that the gacA gene encodes the cognate response-regulator for the lemA sensor in Pseudomonas syringae. J Bacteriol 176: 7468-7475.
56. Schiemann, D.A. (1995) Association with MDCK epithelial cells by Salmonella typhimurium is reduced during utilization of carbohydrates. Infect Immun 63: 1462-1467.
57. Skorupski, K., and Taylor, R.K. (1997) Control of the ToxR virulence regulon in Vibrio cholerae by environmental stimuli. Mol Microbiol 25: 1003-1009.
58. Soisson, S.M., MacDougall-Shackleton, B., Schleif, R., and Wolberger, C. (1997) Structural basis for ligand-regulated oligomerization of AraC. Science 276: 421-425.
59. Stibitz, S., Black, W., and Falkow, S. (1986) The construction of a cloning vector designed for gene replacement in Bordetella pertussis. Gene 50: 133-140.
60. Takeuchi, A. (1967) Electron microscope studies of experimental Salmonella infection. I. Penetration into the intestinal epithelium by Salmonella typhimurium. Am J Pathol 50: 109-136.
61. Tartera, C., and Metcalf, E.S. (1993) Osmolarity and growth phase overlap in regulation of Salmonella typhi adherence to and invasion of human intestinal cells. Infect Immun 61: 3084-3089.
62. Tobe, T., Yoshikawa, M., Mizuno, T., and Sasakawa, C. (1993) Transcriptional control of the invasion regulatory gene virB of Shigella flexneri: activation by VirF and repression by H-NS. J Bacteriol 175: 6142-6149.
63. Tupper, A.E., Owen-Hughes, T.A., Ussery, D.W., Santos, D.S., Ferguson, D.J.P., Sidebothan, J.M., et al. (1994) The chromatin-associated protein H-NS alters DNA topology in vitro. EMBO J 13: 258-268.
64. Virlogeux, I., Waxin, H., Ecobichon, C., Lee, J.O., and Popoff, M.Y. (1996) Characterization of the rcsA and rcsB genes from Salmonella typhi: rcsB through tviA is involved in regulation of Vi antigen synthesis. J Bacteriol 178: 1691-1698.
65. Wang, R.F., and Kushner, S.R, (1991) Construction of versatile low-copy-number vectors for cloning, sequencing, and gene expression in E. coli. Gene 100: 195-199.
66. Wood, M.W., Rosqvist, R., Mullan, P.B., Edwards, M.H., and Galyov, E.E. (1996) SopE, a secreted protein of Salmonella dublin, is translocated into the target eukaryotic cell via a sip-dependent mechanism and promotes bacterial entry. Mol Microbiol 22: 327-338.