Association and colocalization of the Kvβ1 and Kvβ2 β-subunits with Kv1 α-subunits in mammalian brain K+ channel complexes

Journal of Neuroscience

Volumn 17, Issue 21, 1997, Pages 8246-8258

  Rhodes, Kenneth J ^a   Strassle, Brian W ^a   Monaghan, Michael M ^a   Bekele Arcuri, Zewditu ^b   Matos, Maria F ^b   Trimmer, James S ^b  

^a PFIZER INC   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

Central nervous system; Cerebellum; Epilepsy; Immunoflu orescence; Immunohistochemistry; Immunoprecipitation; Ion channel; Striatum

Indexed keywords

ION CHANNEL; POTASSIUM CHANNEL; POTASSIUM ION; DELAYED RECTIFIER POTASSIUM CHANNEL; KCNA2 PROTEIN, RAT; KCNA4 PROTEIN, RAT; KCNB1 PROTEIN, RAT; NERVE PROTEIN; POTASSIUM CHANNEL KV1.1; POTASSIUM CHANNEL KV1.2; POTASSIUM CHANNEL KV1.4; SHAB POTASSIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ANTIBODY SPECIFICITY; ARTICLE; BRAIN SYNAPTOSOME; CENTRAL NERVOUS SYSTEM; CEREBELLUM; EPILEPSY; GLOBUS PALLIDUS; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; NERVE CELL EXCITABILITY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA; ANIMAL; BRAIN LEVEL; CHEMISTRY; ENZYME IMMUNOASSAY; FLUORESCENT ANTIBODY TECHNIQUE; HIPPOCAMPUS; INTERNEURON; PERFORANT NERVE TRACT; RANVIER NODE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BRAIN CHEMISTRY; CEREBELLUM; DELAYED RECTIFIER POTASSIUM CHANNELS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLOBUS PALLIDUS; IMMUNOENZYME TECHNIQUES; INTERNEURONS; KV1.1 POTASSIUM CHANNEL; KV1.2 POTASSIUM CHANNEL; KV1.4 POTASSIUM CHANNEL; MOSSY FIBERS, HIPPOCAMPAL; NERVE TISSUE PROTEINS; ORGAN SPECIFICITY; PERFORANT PATHWAY; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; RANVIER'S NODES; RATS; SHAB POTASSIUM CHANNELS; SUBSTANTIA NIGRA;

EID: 0030612011     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-21-08246.1997     Document Type: Article

References (14)

1. + channel α- and β-subunit polypeptides. Neuropharmacology 35:851-865.
2. + channel β-subunit (hKvβ1.3) is produced via alternative mRNA splicing. J Biol Chem 270:28531-28534.
3. + channel βsubunit expressed in human heart. Proc Natl Acad Sci USA 92:6309-6313.
4. + channel βsubunit to specifically enhance Kv2.2 (CDRK) expression. J Biol Chem 271:26341-26348.
5. + channels in the central nervous system. In: Potassium channels (Cook NS, ed), pp 350-359. New York: Wiley.
6. Harvey AL (1997) Recent studies on dendrotoxins and potassium ion channels. Gen Pharmacol 28:7-12.
7. Heinemann SH, Reuig J, Wunder F, Pongs O (1995) Molecular and functional characterization of a rat brain Kvβ3 potassium channel subunit. FEBS Lett 377:383-389.
8. Heinemann SH, Rettig J, Graack HR, Pongs O (1996) Functional characterization of K-v channel beta-subunits from rat brain. J Physiol (Lond) 493:625-633.
9. Hille B (1992) Ionic channels of excitable membranes. Sunderland, MA: Sinauer.
10. Jan LY, JanYN (1997) Cloned potassium channels from eukaryotes and prokaryotes. Annu Rev Neurosci 20:91-123.
11. Johnson DAG, Sportsman JR, Elder JH (1984) Improved technique utilizing nonfat dry milk for analysis of proteins and nucleic acids transferred to nitrocellulose. Gene Anal Tech 1:3-8.
12. + channels by interaction with a family of membrane-associated guanylate kinases. Nature 387:85-88.
13. Leicher T, Roeper J, Weber K, Wang X, Pongs O (1996) Structural and functional characterization of human potassium channel subunit Kvβ1 (KCNA1B). Neuropharmacology 35:787-796.
14. Maizel JV (1971) Polyacrylamide gel electrophoresis of viral proteins. Methods Virol 5:179-246.