Monophasic and biphasic synovial sarcomas abundantly express cancer/testis antigen NY-ESO-1 but not MAGE-A1 or CT7

International Journal of Cancer

Volumn 94, Issue 2, 2001, Pages 252-256

  Jungbluth, Achim A ^a,b   Antonescu, Cristina R ^a   Busam, Klaus J ^a   Iversen, Kristin ^a   Kolb, Denise ^a   Coplan, Keren ^a   Chen, Yao T ^a   Stockert, Elisabeth ^a   Ladanyi, Marc ^a   Old, Lloyd J ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b NEW YORK PRESBYTERIAN HOSPITAL   (United States)

Author keywords

Cancer testis antigen; CTT; MAGE 1; NY ESO 1; Synovial sarcoma; Translocation type

Indexed keywords

MONOCLONAL ANTIBODY; TUMOR ANTIGEN;

ANTIGEN EXPRESSION; ARTICLE; CANCER IMMUNOTHERAPY; CHROMOSOME 18; CHROMOSOME ABERRATION; CHROMOSOME TRANSLOCATION; GERM CELL; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; SYNOVIAL SARCOMA; X CHROMOSOME;

ANTIGENS, NEOPLASM; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; NEOPLASM PROTEINS; PROTEINS; SARCOMA, SYNOVIAL;

EID: 0035888172     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.1451     Document Type: Article

References (53)

1. Cancer tumor antigens
2. Monitoring CD8 T cell responses to NY-ESO-1: Correlation of humoral and cellular immune responses
3. A survey of the humoral immune response of cancer patients to a panel of human tumor antigens
4. T cell defined tumor antigens
5. Tumor antigens recognized by T lymphocytes
6. New paths in human cancer serology
7. Human neoplasms elicit multiple specific immune responses in the autologous host
8. CT10: A new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational-difference analysis
9. Identification of a new MAGE gene with tumor-specific expression by representational difference analysis
10. Structure, chromosomal location, and expression pattern of three mouse genes homologous to the human MAGE genes
11. Structure, chromosomal localization, and expression of 12 genes of the MAGE family
12. A new MAGE gene with ubiquitous expression does not code for known MAGE antigens recognized by T cells
13. MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: Four new members of the MAGE family with tumor-specific expression
14. A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening
15. LAGE-1, a new gene with tumor specificity
16. Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library
17. Identification of the MAGE-1 gene product by monoclonal and polyclonal antibodies
18. Expression of MAGE-1 and -3 genes and gene products in human hepatocellular carcinoma
19. Identification and intracellular location of MAGE-3 gene product
20. Immunohistochemical analysis of NY-ESO-1 antigen expression in normal and malignant human tissues
21. Immunoreactivity with the anti-MAGE antibody 57B in malignant melanoma: Frequency of expression and correlation with prognostic parameters
22. High expression of MAGE-3 protein in squamous-cell lung carcinoma
23. MAGE-3 immunoreactivity in formalin-fixed, paraffin-embedded primary and metastatic melanoma: Frequency and distribution
24. Expression of MAGE-antigens in normal tissues and cancer
25. Monoclonal antibody MA454 reveals a heterogeneous expression pattern of MAGE-1 antigen in formalin-fixed paraffin embedded lung tumours
26. Diagnosis, treatment and prognosis of patients with synovial sarcoma. The Scandinavian Sarcoma Group experience
27. Cytogenetic findings in two synovial sarcomas
28. Cytogenetics of synovial sarcoma: Presentation of ten new cases and review of the literature
29. Identification of novel genes, SYT and SSX, involved in the t(X; 18)(p11.2;q11.2) translocation found in human synovial sarcoma
30. Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma
31. SSX: A multigene family with several members transcribed in normal testis and human cancer
32. Detection of the SYT-SSX chimeric RNA of synovial sarcoma in paraffin-embedded tissue and its application in problematic cases
33. Detection of the SYT-SSX fusion transcripts in formaldehyde-fixed, paraffin-embedded tissue: A reverse transcription polymerase chain reaction amplification assay useful in the diagnosis of synovial sarcoma
34. Detection of SYT-SSX1/2 fusion transcripts by reverse transcriptase-polymerase chain reaction (RT-PCR) is a valuable diagnostic tool in synovial sarcoma
35. Synovial sarcoma
36. Poorly differentiated synovial sarcoma: Immunohistochemical distinction from primitive neuroectodermal tumors and high-grade malignant peripheral nerve sheath tumors
37. Synovial sarcoma of the extremities: A clinicopathologic study of 34 cases, including semiquantitative analysis of spindled, epithelial, and poorly differentiated areas
38. Poorly differentiated synovial sarcoma: An analysis of clinical, pathologic, and molecular genetic features
39. SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma
40. Two categories of synovial sarcoma defined by divergent chromosome translocation breakpoints in Xpl 1.2, with implications for the histologic sub-classification of synovial sarcoma
41. Alterations of cell cycle regulators in localized synovial sarcoma: A multifactorial study with prognostic implications
42. Strong association of SYT-SSX fusion type and morphologic epithelial differentiation in synovial sarcoma
43. The SYT-SSX1 variant of synovial sarcoma is associated with a high rate of tumor cell proliferation and poor clinical outcome
44. The tumour-associated antigen MAGE-1 is detectable in formalin-fixed paraffin sections of malignant melanoma
45. Identification of MAGE-1 and MAGE-4 proteins in spermatogonia and primary spermatocytes of testis
46. Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines
47. Monoclonal antibodies against recombinant MAGE-1 protein identify a cross-reacting 72-kDa antigen which is co-expressed with MAGE-1 protein in melanoma cells
48. Anti-MAGE-3 antibody 57B and anti-MAGE-1 antibody 6C1 can be used to study different proteins of the MAGE-A family
49. Monoclonal antibody 57B stains tumor tissues that express gene MAGE-A4
50. The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation
51. DNA methylation is the primary silencing mechanism for a set of germ
52. Induction of MAGE genes in lymphoid cells by the demethylating agent 5- aza-2′-deoxycytidine
53. Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2′-deoxycytidine