Poorly differentiated synovial sarcoma: An analysis of clinical, pathologic, and molecular genetic features

American Journal of Surgical Pathology

Volumn 23, Issue 1, 1999, Pages 106-112

  Van De Rijn, Matthijs ^a,d   Barr, Frederic G ^a   Xiong, Qun Bin ^a   Hedges, Mike ^c   Shipley, Janet ^b   Fisher, Cyril ^c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c ROYAL MARSDEN HOSPITAL   (United Kingdom)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chromosomal translocation; Electron microscopy; Poorly differentiated synovial sarcoma; Synovioblastic

Indexed keywords

CYTOKERATIN; EPITHELIAL MEMBRANE ANTIGEN; PROTEIN S 100;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER MORTALITY; CHROMOSOME TRANSLOCATION X; CLINICAL ARTICLE; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; SCHOOL CHILD; SYNOVIAL SARCOMA; TUMOR DIFFERENTIATION;

ADOLESCENT; ADULT; AGED; CHILD; CHROMOSOMES, HUMAN, PAIR 18; DNA PROBES; DNA, NEOPLASM; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SARCOMA, SYNOVIAL; SOFT TISSUE NEOPLASMS; TRANSLOCATION, GENETIC; TUMOR MARKERS, BIOLOGICAL; X CHROMOSOME;

EID: 0032901723     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-199901000-00012     Document Type: Article

References (24)

1. Barr FG, Xiong QB, Kelly K. A consensus polymerase chain reaction-oligonucleotide hybridization approach for the detection of chromosomal translocations in pediatric bone and soft tissue sarcomas. Am J Clin Pathol 1995;104:627-33.
2. Cadman NL, Soule EH, Kelly PJ. Synovial sarcoma. An analysis of 134 tumors. Cancer 1965;18:613-27.
3. Cameron HU, Kostuik JP. A long-term follow-up of synovial sarcoma. J Bone Joint Surg Br 1974;56:613-7.
4. Clark J, Rocques PJ, Crew AJ, et al. Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. Nat Genet 1994;7:502-8.
5. Corson JM, Weiss LM, Banks-Schlegel SP, Pinkus GS. Keratin proteins and carcinoembryonic antigen in synovial sarcomas: an immunohistochemical study of 24 cases. Hum Pathol 1984;15: 615-21.
6. Crew AJ, Clark J, Fisher C, et al. Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. EMBO J 1995;14: 2333-40.
7. Dei Tos AP, Wadden C, Calonje E, et al. Immunohistochemical demonstration of glycoprotein p30/32 MIC2 (CD99) in synovial sarcoma. A potential cause of diagnostic confusion. Applied Immunohistochemistry 1995;3:168-73.
8. Enzinger FM, Weiss SW. Soft tissue tumors. St. Louis: Mosby; 1995.
9. Fernandez BB, Hernandez FJ. Poorly differentiated synovial sarcoma. A light and electron microscopic study. Arch Pathol Lab Med 1976;100:221-3.
10. Fetsch JF, Meis JM. Synovial sarcoma of the abdominal wall. Cancer 1993;72:469-77.
11. Fisher C. Synovial sarcoma: ultrastructural and immunohistochemical features of epithelial differentiation in monophasic and biphasic tumors. Hum Pathol 1986;17:996-1008.
12. Fisher C, Carter RL, Ramachandra S, Thomas DM. Peripheral nerve sheath differentiation in malignant soft tissue tumours: an ultrastructural and immunohistochemical study. Histopathology 1992;20:115-25.
13. Fligman I, Lonardo F, Jhanwar SC, Gerald WL, Woodruff J, Ladanyi M. Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript. Am J Pathol 1995; 147:1592-9.
14. Guillou L, Wadden C, Coindre JM, Krausz T, Fletcher CD. "Proximal-type" epithelioid sarcoma, a distinctive aggressive neoplasm showing rhabdoid features. Clinicopathologic, immunohistochemical, and ultrastructural study of a series. Am J Surg Pathol 1997;21:130-46.
15. Guillou L, Wadden C, Kraus MD, Dei Tos AP, Fletcher CDM. S-100 protein reactivity in synovial sarcomas-a potentially frequent diagnostic pitfall. Applied Immunohistochemistry 1996;4: 167-75.
16. Hampole MK, Jackson BA. Analysis of 25 cases of malignant synovioma. Can Med Assoc J 1968;99:1025-9.
17. MIC2 immunolocaliztion with the O13 monoclonal antibody in the diagnosis of Ewing's sarcoma: application of an algorithmic immunohistochemical analysis. Applied Immunohistochemistry 1997;5:94-103.
18. Hirakawa N, Naka T, Yamamoto I, Fukuda T, Tsuneyoshi M. Overexpression of bcl-2 protein in synovial sarcoma: a comparative study of other soft tissue spindle cell sarcomas and an additional analysis by fluorescence in situ hybridization. Hum Pathol 1996;27:1060-5.
19. Kindblom LG, Meis-Kindblom JM, Bertoni F, et al. Synovial sarcoma: identification of low and high risk groups [abtract]. Mod Pathol 1996;9:8A.
20. Meis-Kindblom JM, Stenman G, Kindblom LG. Differential diagnosis of small round cell tumors. Semin Diagn Pathol 1996;13: 213-41.
21. Noguera R, Lopez-Gines C, Gil R, Carda C, Pellin A, Llombart-Bosch A. Translocation (X;18) in a synovial sarcoma: a new case [letter]. Cancer Genet Cytogenet 1988;33:311-2.
22. Oda Y, Hashimoto H, Tsuneyoshi M, Takeshita S. Survival in synovial sarcoma. A multivariate study of prognostic factors with special emphasis on the comparison between early death and longterm survival. Am J Surg Pathol 1993;17:35-44.
23. Renwick PJ, Reeves BR, Dal Cin P, et al. Two categories of synovial sarcoma defined by divergent chromosome translocation breakpoints in Xp11.2, with implications for the histologic subclassification of synovial sarcoma. Cytogenet Cell Genet 1995;70: 58-63.
24. Shipley J, Crew J, Birdsall S, et al. Interphase fluorescence in situ hybridization and reverse transcription polymerase chain reaction as a diagnostic aid for synovial sarcoma. Am J Pathol 1996;148: 559-67.