Highly conserved amino acids in Pax and Ets proteins are required for DNA binding and ternary complex assembly

Nucleic Acids Research

Volumn 29, Issue 20, 2001, Pages 4154-4165

  Fitzsimmons, Daniel ^a   Lutz, Ryan ^b   Wheat, William ^b   Chamberlin, Helen M ^c   Hagman, James ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BINDING PROTEIN; DNA BINDING PROTEIN; EGL 38 PROTEIN; GLUTAMIC ACID; LIN 1 PROTEIN; MB 1 PROTEIN; PAX PROTEIN; SAP1A PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR PAX5; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; B LYMPHOCYTE; BINDING SITE; CAENORHABDITIS ELEGANS; COMBINATORIAL CHEMISTRY; COMPLEX FORMATION; CONTROLLED STUDY; DNA BINDING; GENE MUTATION; GENETIC CONSERVATION; HUMAN; MOLECULAR EVOLUTION; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SPECIES DIFFERENCE; WORM;

EID: 0035886477     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/29.20.4154     Document Type: Article

References (44)

1. DNA sequence recognition by Pax proteins: Bipartite structure of the paired domain and its binding site
2. Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutations
3. Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding
4. C-terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax-5), Pax-2 and Pax-8
5. Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family
6. Genetic and biochemical diversity in the Pax gene family
7. Undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax-1
8. Molecular basis of splotch and Waardenburg Pax-3 mutations
9. Missense mutations in the PAX6 gene in Aniridia
10. Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas
11. The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas
12. Homology of the eyeless gene of Drosophila to the small eye gene in mice and aniridia in humans
13. Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila
14. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
15. Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors
16. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP
17. Essential functions of Pax5 (BSAP) in pro-B cell development: Difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus
18. The PAX gene egl-38 mediates developmental patterning in Caenorhabditis elegans
19. Characterization of seven genes affecting Caenorhabditis elegans hindgut development
20. Heterogeneously initiated transcription from the pre-B- and B-cell-specific mb-1 promoter: Analysis of the requirement for upstream factor-binding sites and initiation site sequences
21. Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter
22. Specificity within the ets family of transcription factors
23. Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments
24. The highly conserved β-hairpin of the paired DNA-binding domain is required for the assembly of Pax:Ets ternary complexes
25. Cloning, sequencing and expression of mouse c-ets-1 cDNA in baculovirus expression system
26. EGL-38 Pax regulates the ovo-related gene lin-48 during Caenorhabditis elegans organ development
27. An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 gene
28. Overexpression and purification of eukaryotic transcription factors as glutathione-S-transferase fusions in E. coli
29. Determinants of DNA-binding specificity of ETS-domain transcription factors
30. Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: Insights into DNA sequence discrimination by Ets proteins
31. A single amino-acid substitution in the Ets domain alters core DNA binding specificity of Ets1 to that of the related transcription factors Elf1 and E74
32. d) mouse mutant carries a point mutation within the paired box of the pax3 gene
33. The characterization of novel Pax genes of the sea urchin and Drosophila reveal an ancient evolutionary origin of the Pax2/5/8 family
34. The coral Acropora: What it can contribute to our knowledge of metazoan evolution and the evolution of developmental processes
35. Sponge Pax cDNA related to Pax-2/5/8 and ancient gene duplications in the Pax family
36. Pax genes in Caenorhabditis elegans: A new twist
37. Genetic analysis of ETS genes in C. elegans
38. Solution structure of the ETS domain from murine Ets-1: A winged helix-turn-helix DNA binding motif
39. Correction of the NMR structure of the Ets1/DNA complex
40. Structure of the elk-1-DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA
41. Evolution of paired domains: Isolation and sequencing of jellyfish and hydra Pax genes related to Pax-5 and Pax-6
42. Pax gene diversity in the basal cnidarian Acropora millepora (Cnidaria, Anthozoa): Implications for the evolution of the Pax gene family
43. Evolution and functional diversification of the paired box (Pax) DNA-binding domains
44. Molecular phylogeny of the ETS gene family