메뉴 건너뛰기




Volumn 25, Issue 9, 1997, Pages 1022-1031

Hepatic microsomal metabolism of montelukast, a potent leukotriene D4 receptor antagonist, in humans

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; MONTELUKAST; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE;

EID: 0030783057     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (104)

References (24)
  • 3
    • 0029872126 scopus 로고    scopus 로고
    • Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor
    • M. Chiba, M. Hensleigh, J. A. Nishime, S. K. Balani, and J. H. Lin: Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor. Drug Metab. Dispos. 24, 307-314 (1996).
    • (1996) Drug Metab. Dispos. , vol.24 , pp. 307-314
    • Chiba, M.1    Hensleigh, M.2    Nishime, J.A.3    Balani, S.K.4    Lin, J.H.5
  • 5
    • 0029553030 scopus 로고
    • Potent and selective inactivation of human liver microsomal cytochrome P-450 isoforms by L-754,394, and investigational human immune deficiency virus protease inhibitor
    • M. Chiba, J. A. Nishime, and J. H. Lin: Potent and selective inactivation of human liver microsomal cytochrome P-450 isoforms by L-754,394, and investigational human immune deficiency virus protease inhibitor. J. Pharmacol. Exp. Ther. 275, 1527-1534 (1995).
    • (1995) J. Pharmacol. Exp. Ther. , vol.275 , pp. 1527-1534
    • Chiba, M.1    Nishime, J.A.2    Lin, J.H.3
  • 6
    • 0021141593 scopus 로고
    • Spectrophotometric assay of the flavin-containing monooxygenase and changes in its activity in female mouse liver with nutritional and diural conditions
    • A. Dixit and T. E. Roche: Spectrophotometric assay of the flavin-containing monooxygenase and changes in its activity in female mouse liver with nutritional and diural conditions. Arch. Biochem. Biophys. 223, 50-63 (1984).
    • (1984) Arch. Biochem. Biophys. , vol.223 , pp. 50-63
    • Dixit, A.1    Roche, T.E.2
  • 7
    • 0019854279 scopus 로고
    • A pharmacokinetic analysis program (MULTI) for microcomputer
    • K. Yamaoka, Y. Tanigawara, T. Nakagawa, and T. Uno: A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharm. Dyn. 4, 879-885 (1981).
    • (1981) J. Pharm. Dyn. , vol.4 , pp. 879-885
    • Yamaoka, K.1    Tanigawara, Y.2    Nakagawa, T.3    Uno, T.4
  • 8
    • 0023918037 scopus 로고
    • Principles of drug biodisposition in the neonate. A critical evaluation of the pharmacokinetic-pharmacodynamic interface (Part I)
    • J. B. Besunder, M. D. Reed, and J. L. Blumer: Principles of drug biodisposition in the neonate. A critical evaluation of the pharmacokinetic-pharmacodynamic interface (Part I). Clin. Pharmacokinet. 14, 189-216 (1988).
    • (1988) Clin. Pharmacokinet. , vol.14 , pp. 189-216
    • Besunder, J.B.1    Reed, M.D.2    Blumer, J.L.3
  • 9
    • 0024835315 scopus 로고
    • Clinical pharmacokinetics in infants and children. A reappraisal
    • G. L. Kearns and M. D. Reed: Clinical pharmacokinetics in infants and children. A reappraisal. Clin. Pharmacokinet. 17, 29-67 (1989).
    • (1989) Clin. Pharmacokinet. , vol.17 , pp. 29-67
    • Kearns, G.L.1    Reed, M.D.2
  • 11
    • 0017907556 scopus 로고
    • Developmental aspects of drug conjugation, with special reference to glucuronidation
    • G. J. Dutton: Developmental aspects of drug conjugation, with special reference to glucuronidation. Annu. Rev. Pharmacol. 18, 17-35 (1978).
    • (1978) Annu. Rev. Pharmacol. , vol.18 , pp. 17-35
    • Dutton, G.J.1
  • 12
    • 0001440167 scopus 로고
    • Microsomal flavin-containing monooxygenase: Oxygenation of nucleophilic nitrogen and sulfur compounds
    • (W. B. Jakoby, ed.). Academic Press, New York
    • D. M. Ziegler: Microsomal flavin-containing monooxygenase: oxygenation of nucleophilic nitrogen and sulfur compounds. In "Enzyme Basis of Detoxication" (W. B. Jakoby, ed.), vol. 1, pp. 201-227. Academic Press, New York, 1980.
    • (1980) Enzyme Basis of Detoxication , vol.1 , pp. 201-227
    • Ziegler, D.M.1
  • 13
    • 0027462628 scopus 로고
    • Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases
    • D. M. Ziegler: Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases. Annu. Rev. Pharmacol. Toxicol. 33, 179-199 (1993).
    • (1993) Annu. Rev. Pharmacol. Toxicol. , vol.33 , pp. 179-199
    • Ziegler, D.M.1
  • 14
    • 0015090320 scopus 로고
    • N-hydroxylation
    • H. Uehleke: N-hydroxylation. Xenobiotica 1, 327-338 (1971).
    • (1971) Xenobiotica , vol.1 , pp. 327-338
    • Uehleke, H.1
  • 15
    • 0018642835 scopus 로고
    • S-oxygenation of N-substituted thioureas catalyzed by the pig liver microsomal FAD containing monooxygenase
    • L. L. Poulsen, R. M. Hyslop, and D. M. Ziegler: S-oxygenation of N-substituted thioureas catalyzed by the pig liver microsomal FAD containing monooxygenase. Arch. Biochem. Biophys. 198, 78-88 (1979).
    • (1979) Arch. Biochem. Biophys. , vol.198 , pp. 78-88
    • Poulsen, L.L.1    Hyslop, R.M.2    Ziegler, D.M.3
  • 16
    • 0021995799 scopus 로고
    • Loss of rat liver microsomal cytochrome P-450 during methimazole metabolism: Role of flavin-containing monooxygenase
    • G. L. Kedderis and D. E. Rickert: Loss of rat liver microsomal cytochrome P-450 during methimazole metabolism: role of flavin-containing monooxygenase. Drug Metab. Dispos. 13, 58-61 (1985).
    • (1985) Drug Metab. Dispos. , vol.13 , pp. 58-61
    • Kedderis, G.L.1    Rickert, D.E.2
  • 18
    • 0027131401 scopus 로고
    • Role of flavin-dependent monooxygenases and cytochrome P450 enzymes in the sulfoxidation of S-methyl N,N-diethylthiolcarbamate
    • A. Madan, A. Parkinson, and M. D. Faiman: Role of flavin-dependent monooxygenases and cytochrome P450 enzymes in the sulfoxidation of S-methyl N,N-diethylthiolcarbamate. Biochem. Pharmacol. 46, 2291-2297 (1993).
    • (1993) Biochem. Pharmacol. , vol.46 , pp. 2291-2297
    • Madan, A.1    Parkinson, A.2    Faiman, M.D.3
  • 19
    • 0028198648 scopus 로고
    • NADPH-dependent. regioselective S-oxidation of a thionosulfur- and thioether-containing xenobiotic. diethyldithiocarbamate methyl ester by rat liver microsomes
    • A. Madan and M. D. Faiman: NADPH-dependent. regioselective S-oxidation of a thionosulfur- and thioether-containing xenobiotic. diethyldithiocarbamate methyl ester by rat liver microsomes. Drug Metab. Dispos. 22, 324-330 (1994).
    • (1994) Drug Metab. Dispos. , vol.22 , pp. 324-330
    • Madan, A.1    Faiman, M.D.2
  • 20
    • 0029018089 scopus 로고
    • Metabolism of thioridazine by microsomal monooxygenase: Relative roles of P450 and flavin-containing monooxygenase
    • B. L. Blake, R. L. Rose, R. B. Mailman, P. F. Levi, and E. Hodgson: Metabolism of thioridazine by microsomal monooxygenase: relative roles of P450 and flavin-containing monooxygenase. Xenobiotica 25, 377-393 (1995).
    • (1995) Xenobiotica , vol.25 , pp. 377-393
    • Blake, B.L.1    Rose, R.L.2    Mailman, R.B.3    Levi, P.F.4    Hodgson, E.5
  • 22
    • 0026459382 scopus 로고
    • Speculations on the substrate structure-activity relationship (SSAR) of cytochrome P450 enzymes
    • D. A. Smith and B. C. Jones: Speculations on the substrate structure-activity relationship (SSAR) of cytochrome P450 enzymes. Biochem. Pharmacol. 44, 2089-2098 (1992).
    • (1992) Biochem. Pharmacol. , vol.44 , pp. 2089-2098
    • Smith, D.A.1    Jones, B.C.2
  • 23
    • 0029128881 scopus 로고
    • The substrate binding site of human liver cytochrome P450 2C9: An ap proach using designated tienilic acid derivatives and molecular modeling
    • A. Mancy, P. Broto, S. Dijols, P. M. Dansette, and D. Mansuy: The substrate binding site of human liver cytochrome P450 2C9: an ap proach using designated tienilic acid derivatives and molecular modeling. Biochemistry 34, 10365-10375 (1995).
    • (1995) Biochemistry , vol.34 , pp. 10365-10375
    • Mancy, A.1    Broto, P.2    Dijols, S.3    Dansette, P.M.4    Mansuy, D.5
  • 24
    • 0030051678 scopus 로고    scopus 로고
    • Characterization of the self-association property of a leukotriene D4 receptor antagonist, montelukast
    • R. Thibert, H. Mach, S. D. Clas, D. R. Meisner, and E. B. Vadas: Characterization of the self-association property of a leukotriene D4 receptor antagonist, montelukast. Int. J. Pharm. 134, 59-70 (1996).
    • (1996) Int. J. Pharm. , vol.134 , pp. 59-70
    • Thibert, R.1    Mach, H.2    Clas, S.D.3    Meisner, D.R.4    Vadas, E.B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.