De-mystifying the mechanism(s) of maspin

Nature Medicine

Volumn 6, Issue 4, 2000, Pages 374-376

  Hendrix, Mary J C ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MASPIN; OVALBUMIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLASMINOGEN ACTIVATOR INHIBITOR 2; PROTEIN P53; SERINE PROTEINASE INHIBITOR;

BREAST CANCER; BREAST EPITHELIUM; HUMAN; METASTASIS; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; SHORT SURVEY; TUMOR SUPPRESSOR GENE;

ANIMALS; GENE EXPRESSION REGULATION; GENES, TUMOR SUPPRESSOR; HUMANS; PROTEINS; SERINE PROTEINASE INHIBITORS; SERPINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034070764     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/74624     Document Type: Short Survey

References (20)

1. Zou, Z. et al. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. Science 263, 526-529 (1994).
2. Sager, R., Sheng, S., Pemberton, P.A. & Hendrix, M.J.C. in Current Topics in Microbiology and Immunology 213 (eds. Buntert and W. Birchmeier) 51-64 (Springer-Verlag, Berlin, 1996).
3. Zhou, Z. et al. P53 regulates the expression of the tumor suppressor gene. J. Biol. Chem. 275, 6051-6054 (2000).
4. Sheng, S., Pemberton, P.A. & Sager, R. Production, purification, and characterization of recombinant maspin proteins. J. Biol. Chem. 269, 30988-30993 (1994).
5. Sager, R. Function of maspin. Science 265, 1893 (1994).
6. Pemberton, P.A. et al. The tumor suppressor maspin does not undergo the stress to relaxed transition or inhibit trypsin-like serine proteases. J. Biol. Chem. 270, 15832-15837 (1995).
7. Fitzpatrick, P.A., Wong, D.T., Barr, P.J. & Pemberton, P.A. Functional implications of the modeled structure of maspin. Protein Eng. 9, 585-589 (1996).
8. Pemberton, P.A. et al. Maspin is an intracellular serpin that partitions into secretory vesicles and is present at the cell surface. J. Histochem. Cytochem. 45, 1697-1706 (1997).
9. Sheng, S. et al. Tissue-type plasminogen activator is a target of the tumor suppressor gene maspin. Proc. Natl. Acad. Sci. USA. 95, 499-504 (1998).
10. Liu T., Pemberton, P.A. & Robertson, A.D. Three-state unfolding and self-association of maspin, a tumor-suppressing serpin. J. Biol. Chem. 274,29628-29632 (1999).
11. Sheng, S. et al. Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells. Proc. Natl. Acad. Sci. USA 93, 11669-11674 (1996).
12. Sternlicht, M.D. et al. Characterizations of the extracellular matrix and proteinase inhibitor content of human myoepithelial tumors. Laboratory Invest. 74, 781-796 (1996).
13. Sternlicht, M.D. et al. The human myoepithelial cell is a natural tumor suppressor. Clinical Cancer Res. 3, 1949-1958 (1997).
14. Seftor, R.E.B. et al. Maspin suppresses the invasive phenotype of human breast carcinoma. Cancer Res. 58, 5681-5685 (1998).
15. Zhang, M., Volpert, O., Shi, Y.H. & Bouck N. Maspin is an angiogenesis inhibitor. Nature Med. 6, 196-199 (2000).
16. Zhang, M., David, M. & Sager, R. Expression of maspin in prostate cells is regulated by a positive Ets element and a negative hormonal responsive element site recognized by androgen receptor. Proc. Natl. Acad Sci. USA 94, 5673-5678 (1997).
17. Domann, F.E., Rice, J.C., Hendrix, M.J.C. & Futscher, B.W. Epigenetic silencing of maspin gene expression in human breast cancers. Int. J. Cancer 85, 805, 810 (2000).
18. Li, J.-J., Colburn, N.H. & Oberley, L.W. Maspin gene expression in tumor suppression induced by overexpressing manganese-containing superoxide dismutase cDNA in human breast cancer cells. Carcinogenesis 19,833-839 (1998).
19. Mashimo, T. et al. The expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by P53. Proc Natl. Acad. Sci. USA 95, 11307-11311 (1998).
20. Effert, P.J., Neubauer, A., Walther, P.J. & Liu, E.T. Alterations of the P53 gene are associated with the progression of a human prostate carcinoma. J. Urol. 147, 789-793 (1992).