maspin suppresses the invasive phenotype of human breast carcinoma

Cancer Research

Volumn 58, Issue 24, 1998, Pages 5681-5685

  Seftor, Richard E B ^a   Seftor, Elisabeth A ^a   Sheng, Shijie ^b   Pemberton, Philip A ^c   Sager, Ruth ^d   Hendrix, Mary J C ^a  

^a UNIVERSITY OF IOWA   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c LXR Biotechnology   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; ONCOPROTEIN; RECOMBINANT PROTEIN;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CANCER INVASION; CELL TRANSFORMATION; GENE INDUCTION; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ANTIBODIES, BLOCKING; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL ADHESION; CELL SURVIVAL; GENES, TUMOR SUPPRESSOR; HUMANS; INTEGRINS; NEOPLASM INVASIVENESS; PHENOTYPE; PROTEINS; RECEPTORS, FIBRONECTIN; RECOMBINANT PROTEINS; SERPINS; TUMOR CELLS, CULTURED;

EID: 0032535006     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Zou, Z., Anisowicz, A., Hendrix, M. J. C., Thor, A., Neveu, M., Sheng, S., Rafidi, K., Seftor, E., and Sager, R. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. Science (Washington DC), 263: 526-529, 1994.
2. Sager, R., Sheng, S., Pemberton, P., and Hendrix, M. J. C. Maspin. A tumor suppressing serpin. In: U. Buntheit and W. Birchmeier (eds.). Current Topics in Microbiology and Immunology 213, pp. 51-64. Berlin: Springer-Verlag, 1996.
3. Sheng, S., Carey, J., Seftor, E. A., Dias, L., Hendrix, M. J. C., and Sager, R. Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells. Proc. Natl. Acad. Sci. USA. 93: 11669-11674, 1996.
4. Sheng, S., Pemberton, P., and Sager, R. Production, purification, and characterization of recombinant maspin proteins. J. Biol. Chem., 269: 30988-30993, 1994.
5. Sager, R. Function of maspin. Science (Washington DC), 265: 1893, 1994.
6. Pemberton, P. A., Wong, D. T., Gibson, H. L, Kiefer, M. C., Fitzpatrick, P. A., Sager, R., and Barr, P. J. The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. J. Biol. Chem., 270: 15832-15837, 1995.
7. Fitrpatrick, P. A., Wong, D. T., Barr, P. J., and Pemberton, P. A. Functional implications of the modeled structure of maspin. Protein Eng., 9: 585-589, 1996.
8. Pemberton, P. A., Tipton, A. R., Pavloff, N., Smith, J., Erickson, J. R., Mouchabeck, Z. M., and Kiefer, M. C. Maspin is an intracellular serpin that partitions into secretory vesicles and is present at the cell surface. J. Histochem. Cytochem., 45: 1697-1706, 1997.
9. Sheng, S., Truong, B., Fredrickson, D., Wu, R., Pardee, A. B., and Sager, R. Tissue-type plasminogen activator is a target of the tumor suppressor gene maspin. Proc. Natl. Acad. Sci. USA, 95: 499-504, 1998.
10. Umckita, Y., Hiipakka, R. A., and Liao, S. Rat and human maspins: structures, metastatic suppressor activity and mutation in prostate cancer cells. Cancer Lett., 113: 87-93, 1997.
11. Zhang, M., Magit, D., and Sager, R. Expression of maspin in prostate cells is regulated by a positive Ets element and a negative hormonal responsive element site recognized by androgen receptor. Proc. Natl. Acad. Sci. USA, 94: 5673-5678, 1997.
12. Cardarelli, P. M., and Pierschbacher, M. D. Identification of fibronectin receptors on T lymphocytes. J. Cell Biol., 105: 499-506, 1987.
13. 1 integrins during human melanoma cell invasion. Cancer Res., 53: 3411-3415, 1993.
14. Barsky, S. H., Sternlicht, M. D., Safarians, S., Nguyen, M., Chin, K., Stewart, S. D., Hiti, A. L., and Gray, J. W. Evidence of a dominant transcriptional pathway which regulates an undifferentiated and complete metastatic phenotype. Oncogene, 15: 2077-2091, 1997.
15. Zhang, M., Maass, N., Magit, D., and Sager, R. Transactivation through Ets and Ap1 transcriptional sites determines the expression of the tumor-suppressing gene maspin. Cell Growth Differ., 8: 179-186, 1997.
16. Hendrix, M. J. C., Seftor, E. A., Thomas, P. A., Sheng, S., and Seflor, R. E. B. Biological function(s) of maspin. Proc. Am. Assoc. Cancer Res., 38: 436A, 64, 1997.