mMaspin: The mouse homolog of a human tumor suppressor gene inhibits mammary tumor invasion and motility

Molecular Medicine

Volumn 3, Issue 1, 1997, Pages 49-59

  Zhang, Ming ^a   Sheng, Shijie ^a   Maass, Nicolai ^a,c   Sager, Ruth ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; RECOMBINANT PROTEIN; SERINE PROTEINASE INHIBITOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BREAST TUMOR; CANCER INVASION; DOWN REGULATION; GENE EXPRESSION REGULATION; MAMMARY GLAND; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PURIFICATION; SEQUENCE HOMOLOGY; TUMOR SUPPRESSOR GENE;

EID: 0030901111     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03401667     Document Type: Article

References (25)

1. Zou Z, Anisowicz A, Hendrix MJC, Thor A, Neveu M, Sheng S, Rafidi K, Seftor E, Sager R. (1994) Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. Science 263: 526-529.
2. Sager R, Sheng S, Pemberton P, Hendrix MJC. (1995) Maspin, a tumor suppressing serpin. Curr. Top. Microbiol. Immunol. 1: 51-64.
3. Sheng S, Carey J, Seftor AE, Dias L, Hendrix JCM, Sager R. (1996) Maspin acts at the cell membrance to inhibit invasion and motility of mammary and prostate cancer cells. Proc. Natl. Acad. Sci. U.S.A. 93: 11669-11674.
4. Hopkins P, Whisstock J, Sager R. (1994) Function of maspin. Science 265: 1893-1894.
5. Pemberton P, Wong D, Gibson H, Kiefer M, Fitzpatrick P, Sager R, Barr P. (1995) The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. J. Biol. Chem. 270: 15832-15837.
6. Swisshelm K, Ryan K, Lee X, Tsou HC, Peacocke M, Sager R. (1994) Down-regulation of retinoic acid receptor β in mammary carcinoma cell lines and its up-regulation in senescing normal mammary epithelial cells. Cell Growth Differ. 5: 133-141.
7. Laborda J. (1991) 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO. Nucl. Acids Res. 19: 3998.
8. Sambrook J, Fritsch EF, Maniatis T (ed). (1989) Molecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor Laborotory, Cold Spring Harbor, NY.
9. Smith DB, Johnson KS. (1988) Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67: 31-40.
10. Hendrix MJC, Seftor EA, Seftor REB, Fidler IJ. (1987) A simple quantitative assay for studying the invasive potential of high and low human metastatic variants. Cancer Lett. 38: 137-147.
11. Chu YW, Runyan RB, Oshima RG, Hendrix MJC. (1993) Expression of complete keratin filaments in mouse L cells augments cell migration and invasion. Proc. Natl. Acad. Sci. U.S.A. 90: 4261-4265.
12. Travis J, Guzdek A, Potempa J, Watorek W. (1990) Serpins: Structure and mechanism of action. Biol. Chem. Hoppe Seyler 371: 3-11.
13. Huber R, Carrell RW. (1989) Implications of the three dimensional structure of al-antitrypsin for structure and function of serpins. Biochemistry 28: 8951.
14. Coleman S, Silberstein GB, Daniel CW. (1988) Ductal morphogenesis in the mouse mammary gland: Evidence supporting a role for epidermal growth factor. Dev. Biol. 127: 304-315.
15. Robinson SD, Silberstin A, Roberts K, Flanders K, Daniel CW. (1991) Regulated expression and growth inhibitory effects of transforming factor. Development 113: 867-878.
16. Tulchinsky E, Ford HL, Kramerov D, Reshetnyak E, Grigorian M, Zain S, Lukanidin E. (1992) Transcriptional analysis of the mts1 gene with specific reference to 5′ flanking sequences. Proc. Natl. Acad. Sci. U.S.A. 89: 9146-9150.
17. Tulchinsky E, Kramerov D, Ford HL, Reshetnyak E, Lukanidin E, Zain S. (1993) Characterization of a positive regulatory element in the mts1 gene. Oncogene 8: 79-86.
18. Sakakura T. (1991) New aspects of stromalparenchyma relations in mammary gland differentiation. Int. Rev. Cytol. 125: 165-202.
19. Imagawa W, Bandyopadhyay GK, Nandi S. (1990) Regulation of mammary epithelial cell growth in mice and rats. Endocr. Rev. 11: 494-523.
20. Snedeker S, Brown C, DiAugustine R. (1991) Expression and functional properties of transforming factor alpha and epidermal growth factor during mouse mammary gland ductal morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 88: 276-280.
21. Lefebvre O, Wolf C, Limacher J, Hutin P, Wendling C, Lemeur M, Basset P, Rio M. (1992) The breast cancer-associated stromelysis-3 gene is expressed during mouse mammary gland apoptosis. J. Cell Biol. 119: 997-1002.
22. Ossowski L, Biegel D, Reich E. (1979) Correlation with involution, hormonal modulation and comparison between normal and neoplastic tissues. Cell 16: 867-878.
23. Talhouk RS, Chin JR, Unemori EN, Werb Z, Bissell MJ. (1991) Proteinases of the mammary gland: developmental regulation in vivo and vectorial secretion in culture. Development 112: 439-449.
24. Talhouk RS, Bissell MJ, Werb Z. (1992) Coordinated expression of extracellular matrix-degrading proteinase and their inhibitors regulate mammary epithelial function during involution. J. Cell Biol. 118: 1271-1282.
25. Sheng S, Pemberton PA, Sager R. (1994) Production, purification, and characterization of recombinant maspin proteins. J. Biol. Chem. 269: 30988-30993.