Exploring the mechanisms of antigen processing by cell fractionation

Current Opinion in Immunology

Volumn 10, Issue 2, 1998, Pages 145-153

  Pierre, Philippe ^a   Mellman, Ira ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; CELL FRACTIONATION; DENDRITIC CELL; ELECTROPHORESIS; ENDOSOME; LYSOSOME; NONHUMAN; REVIEW;

EID: 0031956851     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(98)80242-2     Document Type: Article

References (64)

1. Cresswell P. Assembly, transport, and function of MHC class II molecules. Annu Rev Immunol. 12:1994;259-293.
2. Wolf PR, Ploegh HL. How MHC class II molecules acquire peptide cargo: Biosynthesis and trafficking through the endocytic pathway. Annu Rev Cell Biol. 11:1995;267-306.
3. Mellman I. Endocytosis and molecular sorting. Annu Rev Cell Biol. 12:1996;575-625.
4. Watts C. Capture and processing of exogenous antigens for presentation on MHC molecules. Annu Rev Immunol. 15:1997;821-850.
5. Cresswell P. Invariant chain structure and MHC class II function. Cell. 84:1996;505-507.
6. Bakke O, Dobberstein B. MHC class II-associated invariant chain contains a sorting signal for endosomal compartments. Cell. 63:1990;707-716.
7. Lotteau V, Teyton L, Peleraux A, Nilsson T, Karlsson L, Schmid SL, Quaranta V, Peterson PA. Intracellular transport of class II MHC molecules directed by invariant chain. Nature. 348:1990;600-605.
8. Neefjes JJ, Stollorz V, Peters PJ, Geuze HJ, Ploegh HL. The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route. Cell. 61:1990;171-183.
9. Harding CV, Collins DS, Slot JW, Geuze HJ, Unanue ER. Liposome-encapsulated antigens are processed in lysosomes, recycled, and presented to T cells. Cell. 64:1991;393-401.
10. Davidson HW, Reid PA, Lanzavecchia A, Watts C. Processed antigen binds to newly synthesized MHC class II molecules in antigen-specific B lymphocytes. Cell. 67:1991;105-116.
11. Germain RN, Hendrix LH. MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding. Nature. 353:1991;134-139.
12. of outstanding interest Riese RJ, Wolf PR, Brsmme D, Natkin LR, Villadangos JA, Ploegh HL, Chapman HA. Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading. Immunity. 4:1996;357-366 This reports that cathepsin S is responsible for the final step of li degradation and therefore has an essential function in peptide loading.
13. Villadangos JA, Riese RJ, Peters C, Chapman HA, Ploegh HL. Degradation of mouse invariant chain: Roles of cathepsin S and D and the influence of major histocompatibility complex polymorphism. J Exp Med. 186:1997;549-560.
14. Roche PA. HLA-DM: An in vivo facilitator of MHC class II peptide loading. Immunity. 3:1995;259-262.
15. Denzin LK, Cresswell P. HLA-DM induces CLIP dissociation from MHC class II αβ dimers and facilitates peptide loading. Cell. 82:1995;155-165.
16. Cresswell P. Getting peptides into MHC class II molecules. Curr Biol. 4:1994;541-543.
17. of outstanding interest Kropshofer H, Vogt AB, Moldenhauer G, Hammer J, Blum JS, Hammerling GJ. Editing of the HLA-DR-peptide repertoire by HLA-DM. EMBO J. 15:1996;6144-6154 This demonstrates that HLA-DM is able to edit antigenic peptides before definitive binding into the MHC class II peptide binding groove takes place and therefore influences directly the presented antigenic peptide repertoire.
18. Kropshofer H, Arndt SO, Moldenhauer G, Hammerling GJ, Vogt AB. HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH. Immunity. 6:1997;293-302.
19. Kropshofer H, Hammerling GJ, Vogt AB. How HLA-DM edits the MHC class II peptide repertoire: survival of the fittest? Immunol Today. 18:1997;77-82.
20. of special interest Denzin LK, Sant'Angelo DB, Hammond C, Surman MJ, Cresswell P. Negative regulation by HLA-DO of MHC class II restricted antigen processing. Science. 278:1997;106-109 This is a novel and exciting finding - the first demonstration of a role for HLA-DO which acts as a negative regulator of HLA-DM.
21. Palade G. Intracellular aspects of the process of protein secretion. Science. 189:1975;347-358.
22. Mellman I, Simons K. The Golgi complex: in vitro veritas? Cell. 68:1992;829-840.
23. Harding CV, Unanue ER, Slot JW, Schwartz AL, Geuze HJ. Functional and ultrastructural evidence for intracellular formation of major histocompatibility complex class II-peptide complexes during antigen processing. Proc Natl Acad Sci USA. 87:1990;5553-5557.
24. Peters PJ, Neefjes JJ, Oorschot V, Ploegh HL, Geuze HJ. Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments. Nature. 349:1991;669-676.
25. Sanderson F, Kleijmeer MJ, Kelly A, Verwoerd D, Tulp A, Neefjes JJ, Geuze HJ, Trowsdale J. Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments. Science. 266:1994;1566-1569.
26. of special interest Liljedahl M, Kuwana T, Fung-Leung W-P, Jackson MR, Peterson PA, Karlsson L. HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport. EMBO J. 15:1996;4817-4824 It was found that HLA-DO requires association with HLA-DM in order to be transported to the lysosomes.
27. Harding CV, Geuze HJ. Class II MHC molecules are present in macrophage lysosomes and phagolysosomes that function in the phagocytic processing of Listeria monocytogenes for presentation to T cells. J Cell Biol. 119:1992;531-542.
28. Harding CV, Geuze HJ. Immunogenic peptides bind to class II MHC molecules in an early lysosomal compartment. J Immunol. 151:1993;3988-3998.
29. Kleijmeer MJ, Oorschot VM, Geuze HJ. Human resident langerhans cells display a lysosomal compartment enriched in MHC class II. J Invest Dermatol. 103:1994;516-523.
30. Kleijmeer MJ, Ossevoort MA, van Veen CJH, van Hellemond JJ, Neefjes JJ, Kast WM, Melief CJM, Geuze HJ. MHC class II compartments and the kinetics of antigen presentation in activated mouse spleen dendritic cells. J Immunol. 154:1995;5715-5724.
31. Nijman HW, Kleijmeer DJ, Osservoort MA, Oorschot VMJ, Vierboom MPN, van de Keur M, Kenemans P, Kast WM, Geuze HJ, Melief CJM. Antigen capture and major histocompatibility class II compartments of freshly isolated and cultured human blood dendritic cells. J Exp Med. 182:1995;163-174.
32. Calafat J, Nijenhuis M, Janssen H, Tulp A, Dusseljee S, Wubbolts R, Neefjes J. Major histocompatibility complex class II molecules induce the formation of endocytic MIIC-like structures. J Cell Biol. 126:1994;967-977.
33. Holtzman E. Skiekevitz P. Lysosomes. 1989;243-316 Plenum Press, New York.
34. Pierre P, Denzin LK, Hammond C, Drake JR, Amigorena S, Cresswell P, Mellman I. HLA-DM is expressed in conventional and unconventional MHC class II-containing compartments. Immunity. 4:1996;229-239.
35. of outstanding interest Kleijmeer MJ, Morkowski S, Griffith JM, Rudensky AY, Geuze HJ. MHC class II compartments (MIICs) in human and mouse lymphoblasts represent conventional endocytic compartments. J Cell Biol. 139:1997;639-649 This is the best and most precise electron microscopic study on the MHC class II-containing compartment ever performed.
36. Pertoft H, Laurent TC. Isopycnic separation of cells and cell organelles by centrifugation in modified colloidal silica gradients. Catsimpoolas N. Methods of Cell Separation. 1977;25-65.
37. Pertoft H, Wärmegärd B, Höök M. Heterogeneity of lysosomes originating from rat liver parenchimal cells. Metabolic relationship of subpopulations separated by density gradient centrifugation. Biochem J. 174:1978;309-317.
38. Harding CV, Unanue ER. Antigen processing and intracellular Ia. Possible roles of endocytosis and protein synthesis in Ia function. J Immunol. 142:1989;12-19.
39. Tulp A, Verwoerd D, Dobberstein B, Ploegh HL, Pieters J. Isolation and characterization of the intracellular MHC class II compartment. Nature. 369:1994;120-126.
40. West MA, Lucocq JM, Watts C. Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells. Nature. 369:1994;147-151.
41. Qiu Y, Xu X, Wandinger-Ness A, Dalke DP, Pierce SK. Separation of subcellular compartments containing distinct functional forms of MHC class II. J Cell Biol. 125:1994;595-605.
42. Jensen PE. Reduction of disulfide bonds during antigen processing: evidence from a thiol-dependent insulin determinant. J Exp Med. 174:1991;1121-1130.
43. Hampl J, Gradehandt G, Kalbacher H, Rude E. In vitro processing of insulin for recognition by murine T cells results in the generation of a chains with free CysSH. J Immunol. 148:1992;2264-2270.
44. Amigorena S, Drake JR, Webster P, Mellman I. Transient accumulation of new class II molecules in a novel endocytic compartment in B lymphocytes. Nature. 369:1994;113-120.
45. Barnes KA, Mitchell RN. Detection of functional class II-associated antigen: role of a low density endosomal compartment in antigen processing. J Exp Med. 181:1995;1715-1727.
46. Escola J-M, Deleuil F, Stang E, Boretto J, Chavrier P, Gorvel J-P. Characterization of a lysozyme major histocompatibility complex class II molecule loading compartment as a specialized recycling endosome in murine B lymphocytes. J Biol Chem. 271:1996;27360-27365.
47. Castellino F, Germain RN. Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments. Immunity. 2:1995;73-88.
48. Pinet V, Vergelli M, Martin R, Bakke O, Long E. Antigen presentation mediated by recycling at surface HLA-DR molecules. Nature. 375:1995;603-606.
49. Griffin JP, Chu R, Harding CV. Early endosomes and a late endocytic compartment generate different peptide-class II MHC complexes via distinct processing mechanisms. J Immunol. 158:1997;1523-1532.
50. of outstanding interest Cella M, Engering A, Pinet V, Pieters J, Lanzavecchia A. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature. 388:1997;782-787 This reports that human dendritic cells are able to regulate their antigen presentation during maturation by controlling the rate of MHC class II recycling.
51. Schmidt SL, Fuchs R, Male P, Mellman I. Two distinct subpopulations of endosomes involved in membrane recycling and transport to lysosomes. Cell. 52:1988;73-83.
52. Harms E, Kern H, Schneider JA. Human lysosomes can be purified from diploid skin fibroblasts by free flow electrophoresis. Proc Natl Acad Sci USA. 77:1980;6139-6143.
53. Harms E, Kartenbeck J, Darai G, Schneider J. Purification and characterization of human lysosomes from EB-virus transformed lymphoblasts. Exp Cell Res. 131:1981;251-266.
54. Marsh M, Schmid S, Kern H, Harms E, Male P, Mellman I, Helenius I. Rapid analytical and preparative isolation of functional endosomes by free flow electrophoresis. J Cell Biol. 104:1987;875-886.
55. Hannig K, Heidrich HG. Continuous free flow electrophoresis and its application in biology. Bloemendal H. Cell Separation Methods: Electrophoretic Methods. 1977;95-116 Elsevier, Holland.
56. Amigorena S, Webster P, Drake J, Newcomb J, Cresswell P, Mellman I. Invariant chain cleavage and peptide loading in post-endosomal MHC class II vesicles. J Exp Med. 181:1995;1729-1741.
57. Drake JR, Webster P, Cambier JC, Mellman I. Delivery of B cell receptor- internalized antigen to endosomes and class II vesicles. J Exp Med. 186:1997;1299-1306.
58. of outstanding interest Ferrari G, Knight AM, Pieters J. Distinct intracellular compartments involved in invariant chain degradation and antigenic peptide loading of major histocompatibility complex (MHC) class II molecules. J Cell Biol. 139:1997;1433-1446 This article provides additional evidence for the existence of a MHC class II peptide-loading compartment distinct from the conventional endocytic organelles.
59. of outstanding interest Pierre P, Turley SJ, Gatti E, Hull M, Melzer J, Mirza A, Inaba K, Steinman RM, Mellman I. Developmental regulation of MHC class II transport in mouse dendritic cells. Nature. 388:1997;787-792 Mouse dendritic cells are able to regulate MHC class II-restricted presentation by controlling the transport of class II molecules to the lysosomes or to specialized class II vesicles during maturation.
60. James DE, Piper RC. Insulin resistance, diabetes, and the insulin-regulated trafficking of GLUT-4. J Cell. 126:1994;1123-1126.
61. of special interest Brachet V, Raposo G, Amigorena S, Mellman I. II controls the transport of major histocompatibility complex class II to and from lysosomes. J Cell Biol. 137:1997;51-65 This demonstrates that the protease inhibitor leupeptin is able to block the degradation of the invariant chain and induce the transport of MHC class II into the lysosomes.
62. Pond L, Watts C. Characterization of transport of newly assembled T cell-stimulatory MHC class II-peptides complexes from MHC class II compartment to the cell surface. J Immunol. 159:1997;543-553.
63. of special interest Raposo G, Nijman HW, Stoorvogel W, Liejendekker R, Harding CV, Melief CJ, Geuze HJ. B lymphocytes secrete antigen-presenting vesicles. J Exp Med. 183:1996;1161-1172 The first demonstration of the existence of exosomes. Even if their physiological role is not clear, their utilization as immunostimulants might have important medical applications.
64. of special interest Wubbolts R, Fernandez-Borja, Oomen L, Verwoerd D, Janssen H, Calafat J, Tulf A, Dusseljee S, Neefjes J. Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface. J Cell Biol. 135:1996;611-622 This was a technical challenge, and resulted in the first insight into how MHC class II returns to the cell surface. The power of green fluorescence protein (GFP) technology was applied to MHC class II traffic analysis. Some MHC class II compartments can fuse with the plasma membrane directly.