Repetitive elements in the 5′ untranslated region of a human zinc-finger gene modulate transcription and translation efficiency

Genomics

Volumn 76, Issue 1-3, 2001, Pages 110-116

  Landry, Josette Renée ^a   Medstrand, Patrik ^a   Mager, Dixie L ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

5 UTR; Alu; Gene regulation; Retroelements; Zinc finger

Indexed keywords

LUCIFERASE; MESSENGER RNA; ZINC FINGER PROTEIN;

5' UNTRANSLATED REGION; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE CONSTRUCT; GENE EXPRESSION; GENE SEQUENCE; GENETIC ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REGULATORY MECHANISM; REPORTER GENE; RNA STRUCTURE; TRANSCRIPTION REGULATION; TRANSLATION REGULATION;

ANIMALIA; EUKARYOTA; HUMAN ENDOGENOUS RETROVIRUSES;

EID: 0035878327     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.2001.6604     Document Type: Article

References (37)

1. Initial sequencing and analysis of the human genome
2. The impact of L1 retrotransposons on the human genome
3. Alu sequences
4. The viruses in all of us: Characteristics and biological significance of human endogenous retrovirus sequences
5. Endogenous human retroviruses
6. RNAs from all categories generate retrosequences that may be exapted as novel genes or regulatory elements
7. Control of genes by mammalian retroposons
8. Identification and characterization of an Alu-containing, T-cell-specific enhancer located in the last intron of the human CD8α gene
9. Expression of human endogenous retroviral sequences in peripheral blood mononuclear cells of healthy individuals
10. Potential Alu function: Regulation of the activity of double-stranded RNA-activated kinase PKR
11. The frequency and position of Alu repeats in cDNAs, as determined by database searching
12. The human integrin β3 gene is 63 kb and contains a 5′-UTR sequence regulating expression
13. A common genetic polymorphism (46 C to T substitution) in the 5′-untranslated region of the coagulation factor XII gene is associated with low translation efficiency and decrease in plasma factor XII level
14. Transcripts from a novel human KRAB zinc finger gene contain spliced Alu and endogenous retroviral segments
15. Standardized nomenclature for Alu repeats
16. Regulatory activities of the 5′- and 3′-untranslated regions and promoter of the human aggrecan gene
17. An analysis of vertebrate mRNA sequences: Intimations of translational control
18. Adherence to the first-AUG rule when a second AUG codon follows closely upon the first
19. Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure
20. Human 7SL RNA consists of a 140 nucleotide middle-repetitive sequence inserted in an Alu sequence
21. Structure and assembly of the Alu domain of the mammalian signal recognition particle
22. Purification and biochemical characterization of the promoter-specific transcription factor, Sp1
23. Promoter activity and distance constraints of one versus two Sp1 binding sites
24. Promoter-specific activation of RNA polymerase-II transcription by SP1
25. Developmental differences in methylation of human Alu repeats
26. Human Alu subfamilies and their methylation revealed by blot hybridization
27. How does DNA methylation repress transcription
28. The DNA methylation paradox
29. Alu sequences in the coding regions of mRNA: A source of protein variability
30. Exon 2 of human cathepsin B derives from an Alu element
31. Multiple 5′-untranslated exons in the nuclear respiratory factor 1 gene span 47 kb and contribute to transcript heterogeneity and translational efficiency
32. Human a2(VI) collagen gene
33. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
34. Blast 2 sequences - A new tool for comparing protein and nucleotide sequences
35. Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL
36. UTRdb: A specialized database of 5′ and 3′ untranslated regions of eukaryotic mRNAs
37. High-level expression of the Epstein-Barr virus EBNA1 protein in CV1 cells and human lymphoid cells using a SV40 late replacement vector