Multiple 5'-untranslated exons in the nuclear respiratory factor 1 gene span 47 kb and contribute to transcript heterogeneity and translational efficiency

Gene

Volumn 233, Issue 1-2, 1999, Pages 213-224

  Huo, Lei ^a   Scarpulla, Richard C ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Alu elements; Human gene; Mitochondria; Regulation; Splicing; Transcription factor

Indexed keywords

MESSENGER RNA; TRANSCRIPTION FACTOR;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EXON; GENE INSERTION; GENE LOCUS; GENE MAPPING; GENE MUTATION; GENE SEQUENCE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RESPIRATORY CHAIN; RNA STRUCTURE; RNA TRANSLATION; TRANSCRIPTION INITIATION;

5' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; CELL LINE; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; EXONS; GENE EXPRESSION REGULATION; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NF-E2-RELATED FACTOR 1; NUCLEAR RESPIRATORY FACTOR 1; NUCLEAR RESPIRATORY FACTORS; PROTEIN BIOSYNTHESIS; REPETITIVE SEQUENCES, NUCLEIC ACID; RNA, MESSENGER; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANS-ACTIVATORS;

ANIMALIA; MAMMALIA;

EID: 0032791893     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(99)00135-3     Document Type: Article

References (25)

1. Au H.C., Scheffler I.E. Promoter analysis of the human succinate dehydrogenase iron-protein gene. Both nuclear respiratory factors NRF-1 and NRF-2 are required. Eur. J. Biochem. 251:1998;164-174.
2. Braidotti G., Borthwick I.A., May B.K. Identification of regulatory sequences in the gene for 5-aminolevulinate synthase from rat. J. Biol. Chem. 268:1993;1109-1117.
3. Bucher P. Weight matrix descriptions of four eukaryotic RNA polymerase II promoter elements derived from 502 unrelated promoter sequences. J. Mol. Biol. 212:1990;563-578.
4. Daga A., Micol V., Hess D., Aebersold R., Attardi G. Molecular characterization of the transcription termination factor from human mitochondria. J. Biol. Chem. 268:1993;8123-8130.
5. Evans M.J., Scarpulla R.C. Interaction of nuclear factors with multiple sites in the somatic cytochrome c promoter. Characterization of upstream NRF-1, ATF and intron Sp1 recognition sites. J. Biol. Chem. 264:1989;14361-14368.
6. Evans M.J., Scarpulla R.C. NRF-1: a trans-activator of nuclear-encoded respiratory genes in animal cells. Genes Dev. 4:1990;1023-1034.
7. Goguel V., Rosbash M. Splice site choice and splicing efficiency are positively influenced by pre-mRNA intramolecular base pairing in yeast. Cell. 72:1993;893-901.
8. Gomez-Cuadrado A., Martin M., Noel M., Ruiz-Carrillo A. Initiation binding receptor, a factor that binds to the transcription initiation site of the histone h5 gene, is a glycosylated member of a family of cell growth regulators. Mol. Cell Biol. 15:1995;6670-6685.
9. Gopalakrishnan L., Scarpulla R.C. Structure, expression, and chromosomal assignment of the human gene encoding nuclear respiratory factor 1. J. Biol. Chem. 270:1995;18019-18025.
10. Graham F.L., van der Eb A.J. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology. 52:1973;456-467.
11. Gugneja S., Virbasius J.V., Scarpulla R.C. Four structurally distinct non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain. Mol. Cell. Biol. 15:1995;102-111.
12. Howe K.J., Ares M. Intron self-complementarity enforces exon inclusion in a yeast pre-mRNA. Proc. Natl. Acad. Sci. USA. 94:1997;12467-12472.
13. Jurka J., Milosavljevic A. Reconstruction and analysis of human Alu genes. J. Mol. Evol. 32:1991;105-121.
14. Kozak M. Influences of mRNA secondary structure on initiation by eukaryotic ribosomes. Proc. Natl. Acad. Sci. USA. 83:1986;2850-2854.
15. Kozak M. Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs. Mol.Cell Biol. 9:1989;5134-5142.
16. Krieg P.A., Melton D.A. In vitro RNA synthesis with SP6 RNA polymerase. Methods Enzymol. 155:1987;397-415.
17. Kunkel T.A. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA. 82:1985;488-492.
18. Li W.-H., Graur D. Rates and patterns of nucleotide substitution. Fundamentals of Molecular Evolution. 1991;Sinauer Associates, Sunderland, MA.
19. Mount S.M. A catalogue of splice junction sequences. Nucleic Acids Res. 10:1982;459-472.
20. Scarpulla R.C. Nuclear respiratory factors and the pathways of nuclear-mitochondrial interaction. Trends Cardiovasc. Med. 6:1996;39-45.
21. Scarpulla R.C. Nuclear control of respiratory chain expression in mammalian cells. J. Bioenerget. Biomembranes. 29:1997;109-119.
22. Shadel G.S., Clayton D.A. Mitochondrial DNA maintenance in vertebrates. Annu. Rev. Biochem. 66:1997;409-435.
23. Virbasius C.A., Virbasius J.V., Scarpulla R.C. NRF-1, an activator involved in nuclear-mitochondrial interactions utilizes a new DNA-binding domain conserved in a family of developmental regulators. Genes Dev. 7:1993;2431-2445.
24. Virbasius J.V., Scarpulla R.C. Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis. Proc. Natl. Acad. Sci. USA. 91:1994;1309-1313.
25. Zuker M. On finding all suboptimal foldings of an RNA molecule. Science. 244:1989;48-52.