The CD2-subset of the Ig superfamily of cell surface molecules: Receptor-ligand pairs expressed by NK cells and other immune cells

Seminars in Immunology

Volumn 12, Issue 2, 2000, Pages 149-157

  Tangye, Stuart G ^a,b   Phillips, Joseph H ^b   Lanier, Lewis L ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

CD2; NK cells; SAP; T cells; X linked lymphoproliferative syndrome

Indexed keywords

CD150 ANTIGEN; CD2 ANTIGEN; CD48 ANTIGEN; CD84 ANTIGEN; CELL SURFACE RECEPTOR; IMMUNOGLOBULIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; LYMPHOCYTE MEMBRANE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN RECOGNITION; CELL ACTIVATION; CELL POPULATION; CHROMOSOMAL LOCALIZATION; CHROMOSOME 1P; CHROMOSOME 1Q; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; LEUKOCYTE; LYMPHOCYTE ACTIVATION; LYMPHOPROLIFERATIVE DISEASE; MOUSE; NATURAL KILLER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RAT; REVIEW; T LYMPHOCYTE ACTIVATION; X CHROMOSOME LINKAGE;

EID: 0034109091     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.2000.0217     Document Type: Article

References (76)

1. Bierer BE, Hahn WC. T cell adhesion, avidity regulation and signaling: a molecular analysis of CD2. Semin Immunol. 5:1993;249-261.
2. +human thymic B cell subset. J Immunol. 151:1993;100-110.
3. Thorley-Lawson DA, Schooley RT, Bhan AK, Nadler LM. Epstein-Barr virus superinduces a new human B cell differentiation antigen (B-LAST 1) expressed on transformed lymphoblasts. Cell. 30:1982;415-425.
4. Yokoyama S, Staunton D, Fisher R, Amiot M, Fortin JJ, Thorley-Lawson DA. Expression of the Blast-1 activation/adhesion molecule and its identification as CD48. J Immunol. 146:1991;2192-2200.
5. Kishimoto T, Kikutani H, von demBorne AEG, Goyert SM, Mason DY, Miyasaka M, Moretta L, Okumura K, Shaw S, Springer TA, Sugamura K, Zola H. Leucocyte typing VI. 1997;Garland Publishing Inc, New York.
6. de la Fuente MA, Pizcueta P, Nadal M, Bosch J, Engel P. CD84 leukocyte antigen is a new member of the Ig superfamily. Blood. 90:1997;2398-2405.
7. Sidorenko SP, Clark EA. Characterization of a cell surface glyco protein IPO-3, expressed on activated human B and T lymphocytes. J Immunol. 151:1993;4614-4624.
8. Cocks BG, Chang C-CJ, Carballido JM, Yssel H, de Vries JE, Aversa G. A novel receptor involved in T-cell activation. Nature. 376:1995;260-263.
9. Aversa G, Carballido J, Punnonen J, Chang CC, Hauser T, Cocks BG, de Vries JE. SLAM and its role in T cell activation and Th cell responses. Immunol Cell Biol. 75:1997;202-205.
10. Punnonen J, Cocks BG, Carballido JM, Bennett B, Peterson D, Aversa G, de Vries JE. Soluble and membrane-bound forms of signaling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B lymphocytes. J Exp Med. 185:1997;993-1004.
11. Valiante NM, Trinchieri G. Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes. J Exp Med. 178:1993;1397-1406.
12. Garni-Wagner BA, Purohit A, Mathew PA, Bennett M, Kumar V. A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells. J Immunol. 151:1993;60-70.
13. Nakajima H, Cella M, Langen H, Friedlein A, Colonna M. Activating interactions in human NK cell recognition: the role of 2B4-CD48. Eur J Immunol. 29:1999;1676-1683.
14. Mathew PA, Garni-Wagner BA, Land K, Takashima A, Stoneman E, Bennett M, Kumar V. Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. J Immunol. 151:1993;5328-5337.
15. Seed B, Aruffo A. Molecular cloning of the CD2 antigen, the T-cel l erythrocyte receptor, by a rapid immuno- selection procedure. Proc Natl Acad Sci USA. 84:1987;3365-3369.
16. Wallner BP, Frey AZ, Tizard R, Mattaliano RJ, Hession C, Sanders ME, Du stin ML, Springer TA. Primary structure of lymphocyte function-associated antigen 3 (LFA-3). The ligand of the T lymphocyte CD2 glycoprotein. J Exp Med. 166:1987;923-932.
17. Tangye SG, Lazetic S, Woollatt E, Sutherland GR, Lanier LL, Phillips, JH. Human 2B4, an activating natural killer cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. J Immunol. 162:1999;6981-6985.
18. Castro AG, Hauser TM, Cocks BG, Abrams J, Zurawski S, Churakova T, Zonin F, Robinson D, Tangye SG, Aversa G, Nicols KE, de Vries J, Lanier LL, O'Garra A. Molecular and functional characterization of mouse SLAM: differential expression and responsiveness in Th1 and Th2 cells. J Immunol, 1999.
19. de la Fuente MA, Tovar V, Pizcueta P, Nadal M, Bosch J, Engel P. Molecular cloning, characterization, and chromosomal localization of the mouse homologue of CD84, a member of the CD2 family of cell surface molecules. Immunogenetics. 49:1999;249-255.
20. Sandrin MS, Gumley TP, Henning MM, Vaughan HA, Gonez LJ, Trapani JA, McKenzie IF. Isolation and characterization of cDNA clones for mouse Ly-9. J Immunol. 149:1992;1636-1641.
21. Sandrin MS, Henning MM, Lo MF, Baker E, Sutherland GR, McKenzie IF. Isolation and characterization of cDNA clones for Humly9: the human homologue of mouse Ly9. Immunogenetics. 43:1996;13-19.
22. Diamond DJ, Clayton LK, Sayre PH, Reinherz EL. Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes. Proc Natl Acad Sci USA. 85:1988;1615-1619.
23. Wong YW, Williams AF, Kingsmore SF, Seldin MF. Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3. J Exp Med. 171:1990;2115-2130.
24. Stepp SE, Schatzle JD, Bennett M, Kumar V, Mathew PA. Gene structure of the murine NK cell receptor 2B4: presence of two alternatively spliced isoforms, with distinct cytoplasmic domains. Eur J Immumol. 29:1999;2392-2399.
25. Boles KS, Nakajima H, Colonna M, Chuang SS, Stepp SE, Bennett M, Kumar V, Mathew PA. Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4. Tissue Antigens. 54:1999;27-34.
26. Seed B. An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2. Nature. 329:1987;840-842.
27. Staunton DE, Fisher RC, LeBeau MM, Lawrence JB, Barton DE, Francke U, D ustin M, Thorley-Lawson DA. Blast-1 possesses a glycosyl-phosphatidylinositol (GPI) membrane anchor, is related to LFA-3 and OX-45, maps to chromosome 1q21-23. J Exp Med. 169:1989;1087-1089.
28. Stefanova I, Horejsi V, Ansotegui IJ, Knapp W, Stockinger H. GPI- anchored cell-surface molecules complexed to protein tyrosine kinases. Science. 254:1991;1016-1019.
29. Moran M, Miceli MC. Engagement of GPI-linked CD48 contributes to TCR signals and cytoskeletal reorganization: a role for lipid rafts in T cell activation. Immunity. 9:1998;787-796.
30. Sewell WA, Palmer RW, Spurr NK, Sheer D, Brown MH, Bell Y, Crumpton MJ. The human LFA-3 gene is located at the same chromosome band as the gene for its receptor CD2. Immunogenetics. 28:1988;278-282.
31. Davis SJ, Ikemizu S, Wild MK, van der Merwe PA. CD2 and the nature of protein interactions mediating cell-cell recognition. Immunol Rev. 163:1998;217-236.
32. Clayton LK, Ramachandran H, Pravtcheva D, Chen YF, Diamond DJ, Ruddle FH, Reinherz EL. The gene for T11 (CD2) maps to chromosome 1 in humans and to chromosome 3 in mice. J Immunol. 140:1988;3617-3621.
33. Kubota K, Katoh H, Muguruma K, Koyama K. Characterization of a surface membrane molecule expressed by natural killer cells in most inbred mouse strains: monoclonal antibody C9.1 identifies an allelic form of the 2B4 antigen. Immunology. 96:1999;491-497.
34. Kingsmore SF, Souryal CA, Watson ML, Patel DD, Seldin MF. Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1. Immunogenetics. 42:1995;59-62.
35. Williams AF, Barclay AN. The immunoglobulin superfamily - domains for cell surface recognition. Annu Rev Immunol. 6:1988;381-405.
36. Selvaraj P, Plunkett ML, Dustin M, Sanders ME, Shaw S, Springer TA. The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3. Nature 1987. 326:1987;400-403.
37. Kato K, Koyanagi M, Okada H, Takanashi T, Wong YW, Williams AF, Okumura K, Yagita H. CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation. J Exp Med. 176:1992;1241-1249.
38. Sandrin MS, Mouhtouris E, Vaughan HA, Warren HS, Parish CR. CD48 is a low affinity ligand for human CD2. J Immunol. 151:1993;4606-4613.
39. Arulanandam AR, Moingeon P, Concino MF, Recny MA, Kato K, Yagita H, Koyasu S, Reinherz EL. A soluble multimeric recombinant CD2 protein identifies CD48 as a low affinity ligand for human CD2: divergence of CD2 ligands during the evolution of humans and mice. J Exp Med. 177:1993;1439-1450.
40. Brown MH, Boles K, van der Merwe PA, Kumar V, Mathew PA, Barclay AN. 2B4, the natural killer and T cell immumoglobulin superfamily surface protein, is a ligand for CD48. J Exp Med. 188:1998;2083-2090.
41. Latchman Y, McKay PF, Reiser H. Identification of the 2B4 molecule as a counter-receptor for CD48. J Immunol. 161:1998;5809-5812.
42. Azuma M, Ito D, Yagita H, Okumura K, Phillips JH, Lanier LL, Somoza C. B70 antigen is a second ligand for CTLA-4 and CD28. Nature. 366:1993;76-79.
43. Freeman GJ, Gribben JG, Boussiotis VA, Ng JW, Restivo VA Jr, Lombard LA, Gray GS, Nadler LM. Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science. 262:1993;909-911.
44. Richardson N E, Chang H C, Brown N R, Hussey R E, Sayre P H, Reinherz E L. Adhesion domain of human T11 (CD2) is encoded by a single exon. Proc Natl Acad Sci USA. 85: 1989;5176-5180.
45. Wang JH, Smolyar A, Tan K, Liu JH, Kim M, Sun ZY, Wagner G, Reinherz EL. Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors. Cell. 97:1999;791-803.
46. Holter W, Schwarz M, Cerwenka A, Knapp W. The role of CD2 as a re gulator of human T-cell cytokine production. Immunol Rev. 153:1996;107-122.
47. Lanier LL, Corliss B, Phillips JH. Arousal and inhibition of human NK cells. Immunol Rev. 155:1997;145-154.
48. Siliciano RF, Pratt JC, Schmidt RE, Ritz J, Reinherz EL. Activation of cytolytic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein. Nature. 317:1985;428-430.
49. Meuer SC, Hussey RE, Fabbi M, Fox D, Acuto O, Fitzgerald KA, Hodgdon JC, Protentis JP, Schlossman SF, Reinherz EL. An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein. Cell. 36:1984;897-906.
50. Hahn WC, Bierer BE. Separable portions of the CD2 cytoplasmic domain involved in signaling and ligand avidity regulation. J Exp Med. 178:1993;1831-1936.
51. Killeen N, Stuart SC, Littman DR. Development and function of T cells in mice with a disrupted CD2 gene. EMBO J. 11:1992;4329-4336.
52. Gonzalez-Cabrero J, Wise CJ, Latchman Y, Freeman GJ, Sharpe AH, Reiser H. CD48-deficient mice have a pronounced defect in CD4 (+) T cell activation. Free Natl Acad Sci USA. 96:1999;1019-1023.
53. Lanier LL. NK cell receptors. Annu Rev Immunol. 16:1998;359-393.
54. +T cells in HIV-1-infected patients with progressing disease. J Immunol. 162:1999;7563-7568.
55. Carballido JM, Aversa G, Kaltoft K, Cocks BG, Punnonen J, Yssel H, Thestrup-Pedersen K, de Vries JE. Reversal of human allergic T helper 2 responses by engagement of signaling lymphocytic activation molecule. J Immunol. 159:1997;4316-4321.
56. Brown MH, Cantrell DA, Brattsand G, Crumpton MJ, Gullberg M. The CD2 antigen associates with the T-cell antigen receptor CD3 antigen complex on the surface of human T lymphocytes. Nature. 339:1989;551-553.
57. Beyers AD, Spruyt LL, Williams AF. Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Proc Natl Aced Sci USA. 99:1992;2945-2949.
58. Gassmann M, Amrein KE, Flint NA, Schraven B, Burn P. Identification of a signaling complex involving CD2, zeta chain and p59fyn in T lymphocytes. Eur J Immunol. 24:1994;139-144.
59. Moingeon P, Lucich JL, McConkey DJ, Letourneur F, Malissen B, Kochan J, Chang HC, Rodewald HR, Reinherz EL. CD3 zeta dependence of the CD2 pathway of activation in T lymphocytes and natural killer cells. Proc Natl Acad Sci USA. 89:1992;1492-1496.
60. Bockenstedt LK, Goldsmith MA, Dustin M, Olive D, Springer TA, Weiss A. The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor. J Immunol. 141:1988;1904-1911.
61. Bell GM, Bolen JB, Imboden JB. Association of Src-like protein tyrosine kinases with CD2 in rat T lymphocytes and natural killer cells. Mol Cell Biol. 12:1992;5548-5554.
62. Bell GM, Fargnoli J, Bolen JB, Kish L, Imboden JB. The SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2. J Exp Med. 183:1996;169-178.
63. Lin H, Hutchcroft JE, Andoniou CE, Kamoun M, Band H, Bierer BE. Association of p59 (fyn) with the T lymphocyte costimulatory receptor CD2. Binding of the Fyn Src homology (SH) domain is regulated by the Fyn SH2 domain. J Biol Chem. 273:1998;19914-19921.
64. Danielian S, Fagard R, Alcover A, Acuto O, Fischer S. The tyrosin e kinase activity of p561ck is increased in human T cells activated via CD2. Eur J Immunol. 21:1991;1967-1970.
65. Gupta N, Scharenberg AM, Burshtyn DN, Wagtmann N, Lioubin MN, Rohrschneider LR, Kinet JP, Long EO. Negative signaling pathways of the killer cell inhibitory receptor and Fc gamma RIIb1 require distinct phosphatases. J Exp Med. 186:1997;473-478.
66. Sayos J, Wu C, Morra M, Wang N, Zhang X, Allen D, van Schaik S, Notarangelo L, Geha R, Roncarolo MG, Oettgen H, de Vries JE, Aversa G, Terhorst C. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature. 395:1998;462-469.
67. Schatzle JD, Sheu S, Stepp SE, Mathew PA, Bennett M, Kumar V. Characterization inhibitory and stimulatory forms of the marine natural killer cell receptor 2B4. Proc Natl Acad Sci USA. 96:1999;3870-3875.
68. Coffey AJ, Brooksbank RA, Brandau O, Oohashi T, Howell GR, Bye JM, Cahn AP, Durham J, Heath P, Wray P, Pavitt R, Wilkinson J, Leversha M, Huckle E, Shaw-Smith CJ, Dunham AV, Rhodes S, Schuster V, Porta G, Yin L, Serafini P, Sylla B, Zollo M, Franco B, Bentley DR. Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene. Nat Genet. 20:1998;129-135.
69. Nichols KE, Harkin DP, Levitz S, Krainer M, Kolquist KA, Genovese C, Bernard A, Ferguson M, Zuo L, Snyder E, Buckler AJ, Wise C, Ashley J, Lovett M, Valentine MB, Look AT, Gerald W, Housman DE, Haber DA. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc Natl Acad Sci USA. 95:1998;13765-13770.
70. Frearson JA, Alexander DR. The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells. J Exp Med. 187:1998;1417-1426.
71. Pazdrak K, Adachi T, Alam R. Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival. J Exp Med. 186:1997;561-568.
72. Gadina M, Stancato LM, Bacon CM, Larner AC, O'Shea JJ. Involvement of SHP-2 in multiple aspects of IL-2 signaling: evidence for a positive regulatory role. J Immunol. 160:1998;4657-4661.
73. Maeda A, Kurosaki M, Ono M, Takai T, Kurosaki T. Requirement of SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 for paired immunoglobulin-like receptor B (PIR-B)-mediated inhibitory signal. J Exp Med. 197:1998;1355-1360.
74. You M, Yu DH, Feng GS. Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. Mol Cell Biol. 19:1999;2416-2424.
75. Lee KM, Chuang E, Griffin M, Khattri R, Hong DK, Zhang W, Straus D, Samelson LE, Thompson CB, Bluestone JA. Molecular basis of T cell inactivation by CTLA-4. Science. 282:1998;2263-2266.
76. Sullivan JL, Byron KS, Brewster FE, Baker SM, Ochs HD. X-linked lymphoproliferative syndrome. Natural history of the immunodeficiency. J Clin Invest. 71:1983;1765-1778.