Opioid peptide receptor studies. 15. Relative efficacy of 4-[(N-allyl-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide and related compounds at the cloned human δ-opioid receptor

Synapse

Volumn 40, Issue 4, 2001, Pages 269-274

  Xu, Heng ^a,b   Lu, Yi Feng ^a   Thomas, James B ^a   Ivy Carroll, F ^a,b   Rice, Kenner C ^a   Rothman, Richard B ^a,b  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b RTI INTERNATIONAL   (United States)

Author keywords

35S GTP S binding; Analgesics; Intrinsic efficacy; Opioid receptors

Indexed keywords

4 [(N ALLYL 3 METHYL 4 PIPERIDINYL)PHENYLAMINO] N,N DIETHYLBENZAMIDE; 4 [ALPHA (4 ALLYL 2,5 DIMETHYL 1 PIPERAZINYL) 3 METHOXYBENZYL] N,N DIETHYLBENZAMIDE; DELTA OPIATE RECEPTOR; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; LIGAND; NITROGEN; OPIATE AGONIST; PIPERIDINE DERIVATIVE; RTI 5989 54; RTI 5989 61; RTI 5989 62; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG TARGETING; ISOMERISM; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY;

ANIMALS; BENZAMIDES; BINDING SITES; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; NARCOTIC ANTAGONISTS; PIPERIDINES; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, DELTA; SULFUR RADIOISOTOPES;

EID: 0035877344     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/syn.1049     Document Type: Article

References (24)

1. Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety
2. Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding and bioassay of the highly selective δ agonist (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl) -3-methoxybenzyl]-N,N-diethylbenzamide (SNC80) and related novel nonpeptide δ opioid receptor ligands
3. Fentanyl and the 4-anilinopiperidine group of analgesics
4. 50) of an enzymatic reaction
5. Simultaneous analysis of families of sigmoidal curves: Application to bioassay, radioligand assay and physiological dose-response curves
6. The relationship between muscarinic receptor occupancy and adenylate cyclase inhibition in the rabbit myocardium
7. Molecular biology and pharmacology of cloned opioid receptors
8. Protein measurement with the folin phenol reagent
9. Rational drug design and synthesis of a highly selective nonpeptide delta-opioid agonist, (4aS*,12aR*)-4a-(3-hydroxyphenyl) -2-methyl-1,2,3,4,4a,5,12,12a-octa-hydropyrido[3,4-b]acridine (TAN-67)
10. 2a binding sites
11. 35S]GTP-γ-S binding assay
12. Relative efficacies of delta-opioid receptor agonists at the cloned delta-opioid receptor
13. Interaction of endogenous opioid peptides and other drugs with four κ opioid binding sites in guinea pig brain
14. mu-Opioid receptor-stimulated guanosine-5′-O-(gamma-thio)-triphosphate binding in rat thalamus and cultured cell lines: Signal transduction mechanisms underlying agonist efficacy
15. A modification of receptor theory
16. Effects of a highly selective nonpeptide δ opioid receptor agonist, TAN-67, on morphine-induced antinociception in mice
17. Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine
18. Optically pure (-)-4-[(N-allyl-3-methyl-4-piperidinyl)phenylamino]-N,N-diethyl-benzamide displays selective binding and full agonist activity for the delta opioid receptor
19. 4-[(8-Alkyl-8-azabicyclo-[3.2.1]octyl-3-yl)-3-arylanilino] N,N-diethylbenzamides: High affinity, selective ligands for the delta opioid receptor illustrate factors important to antagonist activity
20. 35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells
21. Differential expression of the β-adrenergic receptor modifies agonist stimulation of adenylyl cyclase: A quantitative evaluation
22. 35S]GTP-γ-S binding using cloned μ-opioid receptors
23. Opioid peptide receptor studies. 11. Involvement of Tyr148, Trp318 and His319 of the rat μ-opioid receptor in binding of μ-selective ligands
24. 35S]GTP-γ-S functional binding assay