One polypeptide with two aminoacyl-tRNA synthetase activities

Science

Volumn 287, Issue 5452, 2000, Pages 479-482

  Stathopoulos, Constantinos ^a   Li, Tong ^a   Longman, Randy ^a   Vothknecht, Ute C ^a   Becker, Hubert D ^a   Ibba, Michael ^b   Söll, Dieter ^a  

^a YALE UNIVERSITY   (United States)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSFER RNA LIGASE; CYSTEINE TRANSFER RNA; PROLINE TRANSFER RNA;

AMINO TERMINAL SEQUENCE; AMINOACYLATION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; EVOLUTION; METHANOCOCCUS JANNASCHII; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

AMINO ACYL-TRNA SYNTHETASES; BINDING SITES; CYSTEINE; ESCHERICHIA COLI; EVOLUTION, MOLECULAR; GENES, ARCHAEAL; METHANOCOCCUS; MULTIENZYME COMPLEXES; PROLINE; RNA, TRANSFER, AMINO ACYL; SEQUENCE ANALYSIS, PROTEIN; SUBSTRATE SPECIFICITY; TRANSFER RNA AMINOACYLATION; TRANSFORMATION, BACTERIAL;

ARCHAEA; METHANOCALDOCOCCUS JANNASCHII; METHANOCOCCUS; PROKARYOTA;

EID: 0034695470     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.287.5452.479     Document Type: Article

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33. We thank C. A. Hutchison III for sharing unpublished results, and A. Ambrogelly, C. Becker, G. Raczniak, and D. Tumbula for assistance and advice. H.D.B. is a European Molecular Biology Organization postdoctoral fellow, M.I. is supported by an Investigator Fellowship from the Alfred Benzon Foundation and D.S. by grants from the National Institute of General Medical Sciences, NASA, and the Department of Energy.