Mutations in the TAR hairpin affect the equilibrium between alternative conformations of the HIV-1 leader RNA

Nucleic Acids Research

Volumn 29, Issue 12, 2001, Pages 2594-2600

  Huthoff, H ^a   Berkhout, B ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; MAGNESIUM ION; SODIUM ION; VIRUS RNA;

5' UNTRANSLATED REGION; ARTICLE; COMPETITION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIMERIZATION; GENE MUTATION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; RNA CONFORMATION; RNA STRUCTURE;

EID: 0035875554     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/29.12.2594     Document Type: Article

References (37)

1. Structure and function of the Human Immunodeficiency Virus leader RNA
2. Conformation of the TAR RNA-arginine complex by NMR spectroscopy
3. The structure of the human immunodeficiency virus type 1 TAR RNA reveals principles of RNA recognition by Tat protein
4. Structure of HIV-1 TAR RNA in the absence of ligands reveals a novel conformation of the trinucleotide bulge
5. A 1.3-Å resolution crystal structure of the HIV-1 trans-activation response region RNA stem reveals a metal ion-dependent bulge conformation
6. Structural features in TAR RNA of human and simian immunodeficiency viruses: A phylogenetic analysis
7. Evolution of a disrupted TAR RNA hairpin structure in the HIV-1 virus
8. Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus
9. The trans-activator gene of HTLV-III is essential for virus replication
10. Tat trans-activates the human immunodeficiency virus through a nascent RNA target
11. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA
12. Mutant human immunodeficiency virus type 1 genomes with defects in RNA dimerization or encapsidation
13. The 5′ and 3′ TAR elements of the human immunodeficiency virus exert effects at several points in the virus life cycle
14. Genetic dissociation of the encapsidation and reverse transcription functions in the 5′R region of human immunodeficiency virus type 1
15. An intact TAR element and cytoplasmic localization are necessary for efficient packaging of human immunodeficiency virus type 1 genomic RNA
16. The human immunodeficiency virus type 1 TAR RNA upper stem-loop plays distinct roles in reverse transcription and RNA packaging
17. Multiple biological roles associated with the repeat (R) region of the HIV-1 RNA genome
18. Two alternating structures of the HIV-1 leader RNA
19. The leader of the HIV-1 RNA genome forms a compactly folded tertiary structure
20. Identification of the primary site of the human immunodeficiency virus type 1 RNA dimerization in vitro
21. A 19-nucleotide sequence upstream of the 5′ major splice donor is part of the dimerization domain of human immunodeficiency virus 1 genomic RNA
22. Structure of the dimer initiation complex of HIV-1 genomic RNA
23. Convergence of natural and artificial evolution on an RNA loop-loop interaction: The HIV-1 dimerization initiation site
24. On finding all suboptimal foldings of an RNA molecule
25. Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure
26. HIV-1 genome dimerization: Formation kinetics and thermal stability of dimeric HIV-1LAI RNAs are not improved by the 1-232 and 296-790 regions flanking the kissing-loop domain
27. Structural requirement for the two-step dimerization of human immunodeficiency virus type 1 genome
28. Dimerization of HIV-1 genomic RNA of subtypes A and B: RNA loop structure and magnesium binding
29. An unconventional origin of metalion rescue and inhibition in the Tetrahymena group I ribozyme reaction
30. The structure of an RNA 'kissing' hairpin complex of the HIV TAR hairpin loop and its complement
31. Role of the DIS hairpin in replication of human immunodeficiency virus type 1
32. Evidence that a kissing loop structure facilitates genomic RNA dimerisation in HIV-1
33. A dual role of the putative RNA dimerization initiation site of human immunodeficiency virus type 1 in genomic RNA packaging and proviral DNA synthesis
34. Variant effects of non-native kissing-loop hairpin palindromes on HIV replication and HIV RNA dimerization: Role of stem-loop B in HIV replication and HIV RNA dimerization
35. Mapping the RNA binding sites for human immunodeficiency virus type-1 Gag and NC proteins within the complete HIV-1 and -2 untranslated leader regions