Genetic dissociation of the encapsidation and reverse transcription functions in the 5' R region of human immunodeficiency virus type 1

Journal of Virology

Volumn 73, Issue 1, 1999, Pages 101-109

  Clever, Jared L ^a   Eckstein, Daniel A ^a   Parslow, Tristram G ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POLYADENYLIC ACID; VIRUS DNA; VIRUS RNA;

ANIMAL CELL; ARTICLE; BASE PAIRING; CONTROLLED STUDY; DNA SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROVIRUS; REVERSE TRANSCRIPTION; RNA SPLICING; RNA STRUCTURE; VIRUS CAPSID; VIRUS GENOME; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

EID: 0032889011     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.1.101-109.1999     Document Type: Article

References (15)

1. Aiken, C., and D. Trono. 1995. Net stimulates human immunodeficiency virus type 1 proviral DNA synthesis. J. Virol. 69:5048-5056.
2. Aldovini, A., and R. A. Young. 1990. Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus. J. Virol. 64:1920-1926.
3. Arts, E. J., S. R. Stetor, X. Li, J. W. Rausch, K. J. Howard, B. Ehresmann, T. W. North, B. M. Wohrl, R. S. Goody, M. A. Wainberg, and S. F. Grice. 1996. Initiation of (-) strand DNA synthesis from tRNA(3Lys) on lentiviral RNAs: implications of specific HIV-1 RNA-tRNA(3Lys) interactions inhibiting primer utilization by retroviral reverse transcriptases. Proc. Natl. Acad. Sci. USA 93:10063-10068.
4. Berkhout, B. 1996. Structure and function of the human immunodeficiency virus leader RNA. Prog. Nucleic Acid Res. Mol. Biol. 54:1-34.
5. Berkowitz, R., J. Fisher, and S. P. Goff. 1996. RNA packaging. Curr. Top. Microbiol. Immunol. 214:177-218.
6. Berkowitz, K. D., M. L. Hammarskjold, C. Helga-Maria, D. Rekosh, and S. P. Goff. 1995. 5′ regions of HIV-1 RNAs are not sufficient for encapsidation: implications for the HIV-1 packaging signal. Virology 212:718-723.
7. Berkowitz, R. D., A. Ohagen, S. Hoglund, and S. P. Goff. 1995. Retroviral nucleocapsid domains mediate the specific recognition of genomic viral RNAs by chimeric Gag polyproteins during RNA packaging in vivo. J. Virol. 69:6445-6456.
8. Clever, J., C. Sassetti, and T. G. Parslow. 1995. RNA secondary structure and binding sites for gag gene products in the 5′ packaging signal of human immunodeficiency virus type 1. J. Virol. 69:2101-2109.
9. Clever, J. L., and T. G. Parslow. 1997. Mutant human immunodeficiency virus type 1 genomes with defects in RNA dimerization or encapsidation. J. Virol. 71:3407-3414.
10. Clever, J. L., M. L. Wong, and T. G. Parslow. 1996. Requirements for kissing-loop-mediated dimerization of human immunodeficiency virus RNA. J. Virol. 70:5902-5908.
11. Collin, M., G. Herbein, L. Montaner, and S. Gordon. 1993. PCR analysis of HIV1 infection of macrophages: virus entry is CD4-dependent. Res. Virol. 144:13-19.
12. Das, A. T., B. Klaver, B. I. Klasens, J. L. van Wamel, and B. Berkhout. 1997. A conserved hairpin motif in the R-U5 region of the human immunodeficiency virus type 1 RNA genome is essential for replication. J. Virol. 71:2346-2356.
13. Dayton, A. I., J. G. Sodroski, C. A. Rosen, W. C. Goh, and W. A. Haseltine. 1986. The trans-activator gene of the human T cell lymphotropic virus type III is required for replication. Cell 44:941-947.
14. Dorfman, T., J. Luban, S. P. Goff, W. A. Haseltine, and H. G. Gottlinger. 1993. Mapping of functionally important residues of a cysteine-histidine box in the human immunodeficiency virus type 1 nucleocapsid protein. J. Virol. 67:6159-6169.
15. Fisher, A. G., M. B. Feinberg, S. F. Josephs, M. E. Harper, L. M. Marselle, G. Reyes, M. A. Gonda, A. Aldovini, C. Debouk, R. C. Gallo, et al. 1986. The trans-activator gene of HTLV-III is essential for virus replication. Nature 320:367-371.