Tsix-mediated repression of Xist accumulation is not sufficient for normal random X inactivation

Human Molecular Genetics

Volumn 10, Issue 13, 2001, Pages 1403-1411

  Morey, C ^a   Arnaud, D ^a   Avner, P ^a   Clerc, P ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CHROMOSOME PROTEIN; RNA; TSIX PROTEIN; UNCLASSIFIED DRUG; XIST PROTEIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL LINE; CONTROLLED STUDY; DIFFUSION; EMBRYO; EMBRYO CELL; EXON; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE INSERTION; GENE LOCATION; GENE LOCUS; GENE REPRESSION; GENE SILENCING; GENE TARGETING; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STEADY STATE; SYNTHESIS; TRANSCRIPTION INITIATION; X CHROMOSOME INACTIVATION;

ANIMALIA;

EID: 0035875043     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/10.13.1403     Document Type: Article

References (31)

1. Gene action in the X chromosome of the mouse (Mus musculus L.)
2. X-chromosome inactivation in mammals
3. Xist has properties of the X-chromosome inactivation centre
4. A 450 kb transgene displays properties of the mammalian X-inactivation center
5. Long-range cis effects of ectopic X-inactivation centres on a mouse autosome
6. Genetic analysis of the mouse X inactivation center defines an 80-kb multifunction domain
7. Xist yeast artificial chromosome transgenes function as X-inactivation centers only in multicopy arrays and not as single copies
8. Controlling elements in the mouse X-chromosome
9. The product of the mouse Xist gene is a 15kb inactive X-specific transcript containing no conserved ORF and located in the nucleus
10. Xist-deficient mice are defective in dosage compensation but not spermatogenesis
11. Requirement for Xist in X chromosome inactivation
12. Role of the Xist gene in X chromosome choosing
13. DNA hypomethylation can activate Xist expression and silence X-linked genes
14. Role of the region 3′ to Xist exon 6 in the counting process of X-chromosome inactivation
15. X chromosome inactivation is mediated by Xist RNA stabilization
16. Stabilization of Xist RNA mediates initiation of X chromosome inactivation
17. A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation
18. A 94kb genomic sequence 3′ to the murine Xist gene reveals an AT rich region containing a new testis specific gene Tsx
19. A new structure for the murine Xist gene and its relationship to chromosome choice/counting during X-chromosome inactivation
20. Tsix, a gene antisense to Xist at the X-inactivation centre
21. Xce haplotypes show modified methylation in a region of the active X chromosome lying 3′ to Xist
22. Functional analysis of the DXPas34 locus, a 3′ regulator of Xist expression
23. Targeted mutagenesis of Tsix leads to non-random X inactivation
24. Disruption of imprinted X inactivation by parent-of-origin effects at Tsix
25. Regulation of imprinted X chromosome inactivation in mice by Tsix
26. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4
27. Inefficient processing impairs release of RNA from the site of transcription
28. Stabilization and localization of Xist RNA are controlled by separate mechanisms and are not sufficient for X inactivation
29. Expression of Xist during mouse development suggests a role in initiation of X chromosome inactivation
30. Teratocarcinomas and embryonic stem cells, a practical approach
31. Generation and characterisation of an ordered lambda clone array for the 460kb region surrounding the murine Xist sequence