A point mutation in the α-actinin-4 gene generates an antigenic peptide recognized by autologous cytolytic T lymphocytes on a human lung carcinoma

Cancer Research

Volumn 61, Issue 10, 2001, Pages 4078-4083

  Echchakir, Hamid ^a   Mami Chouaib, Fathia ^a   Vergnon, Isabelle ^a   Baurain, Jean François ^b   Karanikas, Vaios ^b   Chouaib, Salem ^a   Coulie, Pierre G ^b  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ANTIGENICITY; ARTICLE; CANCER PATIENT; CASE REPORT; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; DNA SEQUENCE; ENDOPLASMIC RETICULUM; HUMAN; LUNG CARCINOMA; MALE; MALIGNANT TRANSFORMATION; MOLECULAR CLONING; MULTIGENE FAMILY; POINT MUTATION; PRIORITY JOURNAL;

ACTININ; AGED; ANTIGENS, NEOPLASM; CARCINOMA, LARGE CELL; DNA, COMPLEMENTARY; DNA, NEOPLASM; EPITOPES, T-LYMPHOCYTE; HLA-A2 ANTIGEN; HUMANS; LUNG NEOPLASMS; MALE; MICROFILAMENT PROTEINS; PEPTIDE FRAGMENTS; POINT MUTATION; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0035872398     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. T cell-defined tumor antigens
2. Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by gene MAGE-3 and presented by HLA-A1
3. Vaccination with MAGE-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma
4. Evidence for in situ expansion of diverse antitumor specific cytotoxic T-lymphocyte clones in a human large cell carcinoma of the lung
5. High frequency of autologous anti-melanoma CTLs directed against an antigen generated by a point mutation in a new helicase gene
6. Derivation of tumor-specific cytolytic T cell clones from two lung cancer patients with long survival
7. Cytotoxic T-lymphocyte response to autologous human squamous cell cancer of the lung: Epitope reconstitution with peptides extracted from HLA-Aw68
8. HER2/neu-derived peptides are shared antigens among human non-small cell lung cancer and ovarian cancer
9. The peptide recognized by HLA-A68.2-restricted, squamous cell carcinoma of the lung-specific cytotoxic T lymphocytes is derived from a mutated elongation factor 2 gene
10. A cyclophilin B gene encodes antigenic epitopes recognized by HLA-A24-restricted and tumor-specific CTLs
11. Identification of a new endoplasmic reticulum-resident protein recognized by HLA-A24-restricted tumor-infiltrating lymphocytes of lung cancer
12. Quantitative analysis of Th1, Th2 and TGF-β1 cytokine expression in tumor. TII, and PBL of non-small cell lung cancer patients
13. A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes
14. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill
15. Phenotypic analysis of antigen-specific T lymphocytes
16. Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion
17. α-actinins and the DMD protein contain spectrin-like repeats
18. Structure of the α-actinin rod: Molecular basis for cross-linking of actin filaments
19. Cloning and characterization of two human skeletal muscle α-actinin genes located on chromosomes 1 and 11
20. The cDNA sequence of a human placental α-actinin
21. An interaction between α-actinin and the β1 integrin subunit in vitro
22. Mapping of the α-actinin binding site within the β1 integrin cytoplasmic domain
23. Association of intercellular adhesion molecule-1 (ICAM-1) with actin-containing cytoskeleton and α-actinin
24. Interaction of α-actinin with the cadherin/catenin cell-cell adhesion complex via α-catenin
25. Mutations in ACTN4, encoding α-actinin-4, cause familial focal segmental glomerulosclerosis
26. Specificity of cell adhesion in development: The cadherin superfamily
27. Cytoskeletal and adhesion proteins as tumor suppressors
28. Medical aspects of the actin cytoskeleton
29. Suppression of tumorigenicity in simian virus 40-transformed 3T3 cells transfected with α-actinin cDNA
30. The human non-muscle α-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells
31. A mutated β-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes
32. Stabilization of β-catenin by genetic defects in melanoma cell lines
33. Cloning of the human α-catenin cDNA and its aberrant mRNA in a human cancer cell line
34. Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the β-catenin gene in a human cancer cell line, HSC-39