A cyclophilin B gene encodes antigenic epitopes recognized by HLA-A24- restricted and tumor-specific CTLs

Journal of Immunology

Volumn 163, Issue 9, 1999, Pages 4994-5004

  Gomi, Shinya ^a   Nakao, Masanobu ^a   Niiya, Fumihiko ^a   Imamura, Yutaka ^b   Kawano, Kouichiro ^a   Nishizaka, Shinya ^a   Hayashi, Akihiko ^a   Sobao, Yuji ^c   Oizumi, Kotaro ^a   Itoh, Kyogo ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b ST MARY S HOSPITAL   (Japan)

^c KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHILIN B; EPITOPE; GAMMA INTERFERON; HLA ANTIGEN;

ANIMAL CELL; ANTIGEN BINDING; ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY; GENETIC ANALYSIS; HLA SYSTEM; HUMAN; HUMAN CELL; INTERFERON PRODUCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; T LYMPHOCYTE ACTIVATION; TUMOR IMMUNOLOGY;

ADENOCARCINOMA; ANTIGENS, NEOPLASM; CYCLOPHILINS; CYTOTOXICITY, IMMUNOLOGIC; EPITOPES, T-LYMPHOCYTE; HLA-A ANTIGENS; HUMANS; IMMUNOPHILINS; INTERFERON TYPE II; LUNG NEOPLASMS; LYMPHOCYTE COUNT; OLIGOPEPTIDES; PEPTIDYLPROLYL ISOMERASE; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; STEM CELLS; T-LYMPHOCYTES, CYTOTOXIC; TUMOR CELLS, CULTURED;

EID: 0032751204     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. van der Bruggen, P., C. Traversari, P. Chomez, C. Lurquin, E. De Plaen, B. van den Eynde, A. Knuth, and T. Boon. 1991. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 254:1643.
2. Kawakami, Y., S. Eliyahu, K. Sakaguchi, P. F. Robbins. L. Rivoltini, J. B. Yannelli, E. Appella, and S. A. Rosenberg. 1994. Identification of the im-munodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2 restricted tumor infiltrating lymphocytes. J. Exp. Med. 180:347.
3. Kawakami, Y., S. Eliyahu, C. H. Delgado, P. F. Robbins, K. Sakaguchi, E. Appella, J. R. Yannelli, G. J. Adema, T. Miki, and S. A. Rosenberg. 1994. Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection. Proc. Natl. Acad. Sei. USA 91:6458.
4. Brichard, V., A. Van Pel, T. Wolfel, C. Wolfel. E. De Plaen, B Lethe, P. Coulie, and T. Boon. 1993. The lyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J. Exp. Med. 178: 489.
5. Robbins, P. F., M. EI-Gamil, Y. F. Li, Y Kawakami, D. Loflus, E. Appella, and S. A. Rosenberg. 1996. A mutated /3-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes. J. Exp. Med. 183:1185.
6. Guilloux, Y., S. Lucas, V. G. Brichard, A. Van Pel, C. Viret, E. De Plaen, F. Brasseur, B. Lethe, F. Jotereau, and T. Boon. 1996. A peptide recognized by human cytolytic T lymphocytes on HLA-A2 melanoma is encoded by an intron sequence of the W-acetylglucosaminyltransferase V gene. J. Exp. Med. 183:1173.
7. Van den Eynde, B., O. Peelers, O. De Backer, B. Gaugler, S. Lucas, and T. Boon. 1995. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. J. Exp. Med. 182:689.
8. Lupelti, R., P. Pisarra, A. Verrecchia, C. Farina, G. Nicolini, A. Anichini, C. Bordignon, M. Sensi, G. Parmiani, and C. Traversari. 1998. Translation of a retained intron in tyrosinase-related protein (TRP) 2 mRNA generates a new cytotoxic T lymphocyte (CTL)-defined and shared human melanoma antigen not expressed in normal cells of the melanocytic lineage. J. Exp. Med 188:1005.
9. Peoples, G. E., P. S. Goedegebuure, R. Smith, D. C. Linehan, I. Yoshino, and T. J. Eberlein. 1995. Breast and ovarian cancer-specific cytotoxic T lymphocytes recognized the same HER-2/ni-derived peptide. Proc. Natl. Acad. Sei. USA 92:432.
10. Fisk, B., T. L. Blevins, J. Wharton, and C. Ioannides. 1995. Identification of an immunodominant peptide of HER-2/neu proto-oncogene recognized by ovarian tumor-specific cytotoxic T lymphocytes lines. J. Exp. Med. 181:2109.
11. Correale, P.. K. Walmsley, C. Nieroda, S. Zaremba. M. Zhu, J. Schlom, and K. Y. Tsang. 1997. In vitro generation of human cytotoxic T lymphocytes specific for peptides derived from prostate-specific antigen. J. Afar/. Cancer Insi. 89:293.
12. Correale, P., K. Walmsley, S. Zaremba, M. Zhu, J. Schlom, and K. Y.Tsang. 1998. Generation of human cylolytic T lymphocyte lines directed against prostate-specific antigen (PSA) employing a PSA oligoepitope peptide. J. Immunol. 161:3186.
13. Doménech, N., R. A. Henderson, and O. J. Finn. 1995. Identification of an HLA-All-restricted epitope from the tandem repeat domain of the epithelial tumor antigen mucin. J. Immunol 155:4766.
14. Tsang, K. Y., S. Zaremba, C. A. Nieroda, M. Z. Zhu, J. M. Hamilton, and J. Schlom. 1995. Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vac-cinia-CEA vaccine. J. Natl. Canter Inst. 87:982.
15. Shichijo, S., M. Nakao, Y. Imai, H. Takasu, M. Kawamoto, F. Niiya, D. Yang, Y. Ton, H. Yamana, and K. Itoh.1998. A gene encoding antigenic peptide of human squamous cell carcinoma recognized by cytotoxic T lymphocytes. J. Exp. Med. 187:277.
16. Rivoltini, L, Y. Kawakami, K. Sakaguchi, S. Southwood, A. Sette, P. F. Robbins, F. M. Marincola, M. L. Salgaller. J. R. Yannelli, E. Appella, and S. A. Rosenberg. 1995. Induction of tumor-reactive CTL from peripheral blood and tumor-infil-trating lymphocytes of melanoma patients by in vitro stimulation with an immunodominant pcplide of the human melanoma antigen MART-1. J. Immtinol 154: 2257.
17. Sugita, S., K. Sagawa, M. Mochizuki, S. Shichijo, and K. Itoh. 1996. Melanocyte lysis by CTL recognizing the MART-1 melanoma antigen in HLA-A2 patients with Vogt-Koyanagi-Harada (VKH) disease. Int. Immunol. 8:799.
18. Rosenberg, S. A., J. C. Yang, D. J. Sehwartzentruber, P. Hwu, F. M. Marincola, S. L. Topalian, N. P. Restifo, M. E. Dudley, S. L. Schwarz, P. J. Spiess, J. R. Wunderlich, M. A. Parkhurst, Y. Kawakami, C. A. Seipp, J. H. Einhorn, and D. E. White. 1998. Immunologie and therapeutic evaluation of synthetic peptide vaccine for the treatment of patients with metastatic melanoma. Nat. Med. 4:321.
19. Salgaller, M. L., A. Afsher, F. M. Marincola, L. Rivoltini, Y. Kawakami, and S. A. Rosenberg. 1995. Recognition of multiple epitopes in the human melanoma antigen gp100 by peripheral blood lymphocytes stimulated in vitro with synthetic peptides. Cancer Kes. 55:4972.
20. Parkhurst, M. R., M. L. Salgaller, S. Southwood, P. F. Robbins, A. Sette, S. A. Rosenberg, and Y. Kawakami. 1996. Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A0201-binding residues. J. Immunol. 157:2539.
21. Imanishi, T., T. Akaza, A. Kimura, K. Tokunaga, and T. Gojobori. 1991. Allele and hapiotype frequencies for HLA and complement loci in various ethnic groups. In HLA, Vol. 1. K. Tsuji. M. Akaza, and T. Sasazaki, eds. Scientific Publications, Oxford, p. 1065.
22. Seki, N., T. Hoshin, M. Kikuchi, A. Hayashi, and K. Itoh. 1997. HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer. Cell, Immunol. 175:101.
23. Kikuchi, M., M. Nakao, Y. Inoue, K. Matsunaga, S. Shichijo, H. Yamana, and K. Itoh. 1999. Identification of a SART1-derived peptide capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes. InI. J. Cancer 81:459.
24. Yamamoto. K.. H. Sakoda, T. Nakajima. T. Kalo, M. Okubo, M. M. Dohi, Y. Mizushima, K. Ito, and K. Nishioka. 1992. Accumulation of multiple T cell clonotypes in the synovial lesions of patients with rheumatoid arthritis revealed by a novel clonality analysis. Int. Immunol. 4:1219.
25. Seito, D., T. Morila, K. Masuoka, T. Maeda, H. Saya, and K. Itoh. Polyclonal uses of T-cell receptor (TCR)a and ßgenes for cylotoxic T lymphocytes in human metastatic melanoma: possible involvement of TCRa in tumor-cell recognition. Int. J. Cancer 58:497.
26. Ibe, M, Y. I. Moore, Y. Kaneko, S. Yokota, and M. Takiguchi. 1996. Role of strong anchor residues in the effective binding of 10-mer and 11-mer peptides to HLA-A2402 molecules, Immunogenetics 44:233.
27. Lee. S. P, R. J. Tierney, W A. Thomas, J. M. Brooks, and A. B. Rickinson. 1997. Conserved CTL epitopes within EBV latent membrane protein 2. J. Immunol. 158:1325.
28. Price, E. R., L. D. Zydowsky, M. Jin, H. Baker, F. D. McKeon, and C. T. Walsh. 1991. Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence. Proc. Natl. Acad. Sci. USA 88:1903.
29. Spik, G., B. Haendler, O. Delmas, C. Mariller, M. Chamoux, P. Maes, A. Tartar, J. Montreuil, K. Stedman, H. P. Kocher, R. Keller, P. C. Hiestand, and N. R. Movva. A novel secreted cyclophilin-like protein. J. Biol. Chem. 266: 10735.
30. Rammensee, H.-G., T. Friede, and S. Stevanovic. 1995. MHC ligands and peptide motifs: first listing. Immunogenetics 41:178.
31. Oiso, M-, M. Eura, F. Katsura, M. Takiguchi, U. Sobao, M. Masuyama, K. Itoh, and T. Ishikawa. 1999. A newly identified MAGE-3-derived epitope recognized by HLA-A24-restricted cytotoxic T lymphocytes. Int. J. Cancer 81:387.
32. Taswell, C. 1981. Limiting dilution assays for the determination of immunocom-petent cell frequencies. 1. Data analysis. J. Immunol. 126:1614.
33. Caron, P., A. Rothenfluh, E. McGlynn, and C. Schneider. 1991. S-cyclophilin. J. Biol. Chem. 266:10739.
34. Emmel, E. A., C. L. Verweij, D. B. Durand, K. M. Higgins, E. Lacy, and G. R. Crabtree. 1989. Cyclophilin A specifically inhibits function of nuclear proteins involved in T cell activation. Science 246:1817.
35. Bergsma, D. J., C Eder, M. Gross, H. Kersten, D. Sylvester, E. Appelbaum, D. Cusimano, G. P. Livi, M. M. McLaughlin, K. Kasyan, T. G. Porter, C. Silverman, D. Dunnington, A. Hand, W. P. Prichett. M. J. Bossard, M. Brandt, and M. A. Levy. 1991. The cyclophilin multigene family of peptidyl-prolyl isomerases. J. Biol Chem. 266:23204.
36. Bram, R. J., and G. R. Crabtree. 1994. Calcium signaling in T cells stimulated by a cyclophilin B-binding protein. Nature 371:355.
37. Schneider, H., N. Charara, R. Schmilz, S. Wehrli, V. Mikol, M. G. M Zurini, V. F. J. Quesniaux, and N. R. Movva. 1994. Human cyclophilin C: primary structure, tissue distribution, and determination of binding specificity for cyclos-porins. Biochemistry 33:8218.
38. Pflugl, G., J. Kallen, T. Schirmer, J. N. Jansonius. M. G. M. Zurini. and M. D. Walkinshaw. 1993. X-ray structure of a decameric cyclophilin-cyclosporin crystal complex. Nature 361:91.
39. Montague, J. W., F. M. Hughes, Jr., and J. A. Cidlowski. 1997. Native recom-binant cyclophilins A. B, and C degrade DNA independency of peplidylprolyl cis-trans-isomerase activity. J. Biol. Chem. 272:6677.
40. Kawakami Y., and S. A Rosenberg. 1996. T-cell recognition of self peptides as tumor rejection antigens. Immunol Res. 15:179.
41. Marincola, F. M., L. Rivoltini, M. L. Salgaller, M. Player, and S. A. Rosenberg. 1996. Differential anti-MART-1/MelanA CTL activity in peripheral blood of-HLA-A2 melanoma patients in comparison to healthy donors: evidence for in vivo priming by tumor cells. J. Immunother. 19:266.
42. Marchand, M.. P. Weynants, E. Rankin, F. Arienti, F. Belli, G. Parmiani, N. Cascinclli, A. Bourlond, R. Vanwijck, Y. Humblet, et al. 1995. Tumor re-gression responses in melanoma patients treated with a peptide encoded by gene MAGE-3. Int. J. Cancer 63:883.
43. Visseren, M. J. W., A. van Elsas, E. I. H. van der Voort, M. E. Ressing, W. M. Kast, P. I. Schrier, and C. J. M. Melief. 1995. CTL specific for the tyrosinase autoantigen can be induced from healthy donor blood to lyse mela-noma cells. J. Immunol. 154:3991.
44. Bird, C. H.. V. R. Sutton. J. Sun, C. E. Hirst, A. Novak, S. Kumar, J. A. Trapani, and P. I. Bird. 1998. Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway. Mol Cell. Biol. 18:6387.
45. Sun, J., L. Ooms, C. H. Bird, V. R. Sutton, J. A. Trapan, and P. I. Bird. 1997. A new family of 10 murine ovalbumin serpins induces two homologs of proteinase inhibitor 8 and two homologs of the granzyne B inhibitor (proteinase inhibitor 9). J. Biol. Chem. 272:15434.
46. Skipper, J. C. A., R. C. Hendrickson, P. H. Gulden, V. Brichard, A. Van Pel, Y. Chen, J. Shabanowitz, T. Wolfel, C. L. Slingluff, T. Boon, D. F. Hunt, and V. H. Engelhard. 1996. An HLA-A2 restricted tyrosinase antigen on melanoma cells results from post-translational modification and suggests a novel processing pathway for membrane proteins. J. Exp. Med. 183:527.
47. Kittlesen, D. J., L. W. Thompson, P. H. Gulden. J. C. A. Skipper, T. A. Colella, J. A. Shabanowitz, D. F. Hunt, V. H. Engelhard, and C. L. Slingluff. 1998. Human melanoma patients recognize an HLA-A1 -restricted CTL epitope from tyrosinase containing two cysteine residue: implications for tumor vaccine development. J. Immunol. 160:2099.