A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: Implications for the docking model of STAT activation

Blood

Volumn 97, Issue 8, 2001, Pages 2230-2237

  Barber, D L ^a   Beattie, B K ^a   Mason, J M ^a   Nguyen, M H H ^a   Yoakim, M ^a   Neel, B G ^a   D'Andrea, A D ^a   Frank, D A ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; EPITOPE; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; JANUS KINASE; PROTEIN ANTIBODY; STAT5 PROTEIN;

ANIMAL CELL; ANTIBODY SPECIFICITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVATION; GENE ACTIVATION; GENETIC CONSERVATION; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

EID: 0035871693     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.8.2230     Document Type: Article

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11. Interleukin-3, erythropoietin, and prolactin activate a STAT5-like factor in lymphoid cells
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14. Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5
15. Erythropoietin induces the tyrosine phosphorylation, nuclear translocation, and DNA binding of STAT1 and STAT5 in erythroid cells
16. The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor
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18. Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways
19. Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis
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58. Erythroblasts from Friend virus infected- and phenylhydrazine-treated mice accurately model erythroid differentiation
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72. Three-dimensional structure of the STAT3beta homodimer bound to DNA