Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: A conformational mechanism for SH3 domain regulation

EMBO Journal

Volumn 16, Issue 3, 1997, Pages 473-483

  Hu, Kang Quan ^a   Settleman, Jeffrey ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

p190; RasGAP; RhoGAP; SH2 domain; SH3 domain

Indexed keywords

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; SIGNAL PEPTIDE; TYROSINE;

ANIMAL CELL; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; NONHUMAN; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; BLOTTING, WESTERN; CLONING, MOLECULAR; COS CELLS; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GTPASE-ACTIVATING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MODELS, BIOLOGICAL; MUTAGENESIS; NUCLEAR PROTEINS; PHOSPHOPEPTIDES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN-TYROSINE KINASES; PROTEINS; RATS; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; SEQUENCE DELETION; SRC HOMOLOGY DOMAINS; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0031030898     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.3.473     Document Type: Article

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