Lack of dominant-negative effects of a truncated γc on retroviral-mediated gene correction of immunodeficient mice

Blood

Volumn 97, Issue 6, 2001, Pages 1618-1624

  Otsu, Makoto ^b   Sugamura, Kazuo ^b   Candotti, Fabio ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA CHAIN PROTEIN; GENE PRODUCT; IMMUNOGLOBULIN; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 7; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENE TRANSFER; HEMATOPOIETIC STEM CELL; IMMUNITY; LEUKOCYTE COUNT; LYMPHOID TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS;

EID: 0035869530     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.6.1618     Document Type: Article

References (37)

1. Human severe combined immunodeficiency: Genetic, phenotypic, and functional diversity in one hundred eight infants
2. Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans
3. The interleukin-2 receptor gamma chain maps to Xq13.1 and is mutated in X-linked severe combined immunodeficiency, SCIDX1
4. Role of the common cytokine receptor gamma chain in cytokine signaling and lymphoid development
5. The common gamma-chain for multiple cytokine receptors
6. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain
7. Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain
8. Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain
9. PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in rag- but not CD3γ-deficient mice
10. Immunological reconstitution of sexlinked lymphopenic immunological deficiency
11. Long-term chimerism and B-cell function after bone marrow transplantation in patients with severe combined immunodeficiency with B cells: A single-center study of 22 patients
12. Hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency
13. Retroviral-mediated gene correction for X-linked severe combined immuno-deficiency
14. Correction of interleukin-2 receptor function in X-SCID lymphoblastoid cells by retrovirally mediated transfer of the gamma-c gene
15. Gamma-c gene transfer into SCID X1 patients' B-cell lines restores normal high-affinity interleukin-2 receptor expression and function
16. Role of interleukin-2 (IL-2), IL-7, and IL-15 in natural killer cell differentiation from cord blood hematopoietic progenitor cells and from gamma c transduced severe combined immunodeficiency X1 bone marrow cells
17. Gamma-c gene transfer in the presence of stem cell factor, FLT-3L, interleukin-7 (IL-7), IL-1, and IL-15 cytokines restores T-cell differentiation from gammac(-) X-linked severe combined immunodeficiency hematopoietic progenitor cells in murine fetal thymic organ cultures
18. Restoration of lymphoid populations in a murine model of X-linked severe combined immunodeficiency by a genetherapy approach
19. Lymphoid development and function in X-linked severe combined immunodeficiency mice after stem cell gene therapy
20. Stable and functional lymphoid reconstitution of common cytokine receptor γ chain-deficient mice by retroviral-mediated gene transfer
21. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease
22. Functional dissection of the HIV-1 Rev trans-activator-derivation of a trans-dominant repressor of Rev function
23. Patient selection may affect gene therapy success: Dominant-negative effects observed for ornithine transcarbamylase in mouse and human hepatocytes
24. Mutation analysis of IL2RG in human X-linked severe combined immunodeficiency
25. A safe packaging line for gene transfer: Separating viral genes on two different plasmids
26. Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4
27. Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes
28. Role of Bcl-2 in α β T cell development in mice deficient in the common cytokine receptor γ-chain: The requirement for Bcl-2 differs depending on the TCR/MHC affinity
29. The common cytokine receptor γ chain and the pre-T cell receptor provide independent but critically overlapping signals in early α/β T cell development
30. Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer
31. Immunoglobulin class switching
32. The IL-4 receptor; signaling mechanisms and biologic functions
33. Growth factors can enhance lymphocyte survival without committing the cell to undergo cell division
34. Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression
35. The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression
36. + T cell survival but not for antigen proliferation
37. In vivo competitive studies between normal and common gamma chain-defective bone marrow cells: Implications for gene therapy